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Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

Cell cycle (Georgetown, Tex.), 2017-10, Vol.16 (19), p.1790-1799

2017

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The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity

Oncotarget, 2014-12, Vol.5 (24), p.12728-12737

2014

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Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis

The Journal of immunology (1950), 2013-11, Vol.191 (10), p.5074-5084

2013

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Empathy Imperiled: Capitalism, Culture, and the Brain

Olson, Gary

1. Aufl., 2013

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HLA-DR15-specific inhibition attenuates autoreactivity to the Goodpasture antigen

Journal of autoimmunity, 2019-09, Vol.103, p.102276-102276, Article 102276

2019

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Concepts and progress in the development of peptide mimetics

Journal of medicinal chemistry, 1993-10, Vol.36 (21), p.3039-3049

1993

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Synthesis of 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives and Evaluation of Their Affinity for MHC Class-II Proteins

Helvetica chimica acta, 1999-12, Vol.82 (12), p.2432-2447

1999

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Inhibition of amyloid β‐peptide production by blockage of β‐secretase cleavage site of amyloid precursor protein

Journal of neurochemistry, 2007-06, Vol.101 (6), p.1583-1595

2007

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Conformational analysis of dipeptide mimetics

Biopolymers, 1997, Vol.43 (3), p.191-217

1997

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Peptide and Peptide Mimetic Inhibitors of Antigen Presentation by HLA-DR Class II MHC Molecules. Design, Structure−Activity Relationships, and X-ray Crystal Structures

Journal of medicinal chemistry, 2000-06, Vol.43 (11), p.2135-2148

2000

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Peptidomimetic compounds that inhibit antigen presentation by autoimmune disease-associated class II major histocompatibility molecules

Nature biotechnology, 1999-06, Vol.17 (6), p.562-567

1999

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Design and Synthesis of a Competent Pyrrolinone−Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1

Journal of the American Chemical Society, 1999-10, Vol.121 (40), p.9286-9298

1999

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Abstract 4826: ONC212 exhibits increased cytotoxicity relative to ONC201 in a subset of human pancreatic cancer cell lines

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.4826-4826

2016

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Peptide Mimetics of Thyrotropin-Releasing Hormone Based on a Cyclohexane Framework: Design, Synthesis, and Cognition-Enhancing Properties

Journal of medicinal chemistry, 1995-07, Vol.38 (15), p.2866-2879

1995

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Abstract 4499: Cytotoxicity, biochemical activity, and structural analysis of ONC201 and comparisons to a biologically inactive isomer

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.4499-4499

2015

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The Crystal Structure of a Pyrrolinone−Peptide Hybrid Ligand Bound to the Human Class II MHC Protein HLA-DR1

Journal of the American Chemical Society, 2000-09, Vol.122 (35), p.8370-8375

2000

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Design, Synthesis, and Evaluation of a Pyrrolinone−Peptide Hybrid Ligand for the Class II MHC Protein HLA-DR1

Journal of the American Chemical Society, 1998-12, Vol.120 (48), p.12704-12705

1998

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Design and synthesis of a protein .beta.-turn mimetic

Journal of the American Chemical Society, 1990, Vol.112 (1), p.323-333

1990

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Dopamine receptor model and its application in the design of a new class of rigid pyrrolo[2,3-g]isoquinoline antipsychotics

Journal of medicinal chemistry, 1981-09, Vol.24 (9), p.1026-1034

1981

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Vitamin A synthesis by sulfone alkylation-elimination. C15 halide, C5 hydroxy sulfone approach

Journal of organic chemistry, 1976-10, Vol.41 (20), p.3287-3293

1976

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Syntheses of an antipsychotic pyrrolo[2,3-g]isoquinoline from areca alkaloids

Journal of organic chemistry, 1984-12, Vol.49 (26), p.5109-5113

1984

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Inhibition of amyloid [beta]-peptide production by blockage of [beta]-secretase cleavage site of amyloid precursor protein

Journal of neurochemistry, 2007-06, Vol.101 (6), p.1583

2007

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APP-specific inhibitor of β-secretase

Journal of neurochemistry, 2007, Vol.101 (6), p.1583-1595

2007

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Oxazole- and imidazole-based Ser-Leu dipeptide mimetics in potent inhibitors of antigen presentation by MHC class II DR molecules

Drug design and discovery, 2002, Vol.18 (1), p.3-7

2002

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Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212

The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity

Small molecule inhibitor of antigen binding and presentation by HLA-DR2b as a therapeutic strategy for the treatment of multiple sclerosis

Empathy Imperiled: Capitalism, Culture, and the Brain

HLA-DR15-specific inhibition attenuates autoreactivity to the Goodpasture antigen

Correction: Discovery and clinical introduction of first-in-class imipridone ONC201

Concepts and progress in the development of peptide mimetics

Synthesis of 1,2,5-Thiadiazolidin-3-one 1,1-Dioxide Derivatives and Evaluation of Their Affinity for MHC Class-II Proteins

Inhibition of amyloid β‐peptide production by blockage of β‐secretase cleavage site of amyloid precursor protein

Conformational analysis of dipeptide mimetics

Peptide and Peptide Mimetic Inhibitors of Antigen Presentation by HLA-DR Class II MHC Molecules. Design, Structure−Activity Relationships, and X-ray Crystal Structures

Peptidomimetic compounds that inhibit antigen presentation by autoimmune disease-associated class II major histocompatibility molecules

Design and Synthesis of a Competent Pyrrolinone−Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1

Abstract 4826: ONC212 exhibits increased cytotoxicity relative to ONC201 in a subset of human pancreatic cancer cell lines

Peptide Mimetics of Thyrotropin-Releasing Hormone Based on a Cyclohexane Framework: Design, Synthesis, and Cognition-Enhancing Properties

Abstract 4499: Cytotoxicity, biochemical activity, and structural analysis of ONC201 and comparisons to a biologically inactive isomer

The Crystal Structure of a Pyrrolinone−Peptide Hybrid Ligand Bound to the Human Class II MHC Protein HLA-DR1

Design, Synthesis, and Evaluation of a Pyrrolinone−Peptide Hybrid Ligand for the Class II MHC Protein HLA-DR1

Design and synthesis of a protein .beta.-turn mimetic

Dopamine receptor model and its application in the design of a new class of rigid pyrrolo[2,3-g]isoquinoline antipsychotics

Vitamin A synthesis by sulfone alkylation-elimination. C15 halide, C5 hydroxy sulfone approach

Syntheses of an antipsychotic pyrrolo[2,3-g]isoquinoline from areca alkaloids

Inhibition of amyloid [beta]-peptide production by blockage of [beta]-secretase cleavage site of amyloid precursor protein

APP-specific inhibitor of β-secretase

Oxazole- and imidazole-based Ser-Leu dipeptide mimetics in potent inhibitors of antigen presentation by MHC class II DR molecules

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