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Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Nature medicine, 2011-12, Vol.17 (12), p.1636-1640

2011

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Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Molecular cancer therapeutics, 2015-06, Vol.14 (6), p.1504-1516

2015

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The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Scientific reports, 2016-06, Vol.6 (1), p.26979-26979, Article 26979

2016

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Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Science translational medicine, 2018-02, Vol.10 (428)

2018

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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Nature communications, 2014, Vol.5 (1), p.3295, Article 3295

2014

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Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

International Journal of Molecular Sciences, 2015-11, Vol.16 (11), p.27313-27326

2015

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Iron chelators target both proliferating and quiescent cancer cells

Scientific reports, 2016-12, Vol.6 (1), p.38343-38343, Article 38343

2016

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The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

Biochemical pharmacology, 2018-10, Vol.156, p.291-301

2018

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Cytokeratin-18 Is a Useful Serum Biomarker for Early Determination of Response of Breast Carcinomas to Chemotherapy

Clinical cancer research, 2007-06, Vol.13 (11), p.3198-3206

2007

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MYC is downregulated by a mitochondrial checkpoint mechanism

Oncotarget, 2017-10, Vol.8 (52), p.90225-90237

2017

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Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

PloS one, 2009-10, Vol.4 (10), p.e7238-e7238

2009

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Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition

Oncotarget, 2017, Vol.8 (13), p.21115-21127

2017

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Screening of natural products for therapeutic activity against solid tumors

Indian journal of experimental biology, 2010-03, Vol.48 (3), p.258-264

2010

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Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Mini reviews in medicinal chemistry, 2007-10, Vol.7 (10), p.1035

2007

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Utilization of cytokeratin-based biomarkers for pharmacodynamic studies

Expert review of molecular diagnostics, 2010-04, Vol.10 (3), p.353-359

2010

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Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three‐dimensional carcinoma culture model

International journal of cancer, 2009-11, Vol.125 (10), p.2450-2455

2009

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HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled Sel-tagged affibody molecule

The Journal of nuclear medicine (1978), 2012-09, Vol.53 (9), p.1446-1453

2012

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Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Chemical biology & drug design, 2011-10, Vol.78 (4), p.547-557

2011

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Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats

Journal of Nuclear Medicine, 2013-10, Vol.54 (10), p.1804-1811

2013

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Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

CANCER RESEARCH, 2015, Vol.75 (S15)

2015

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Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis

Molecular bioSystems, 2010, Vol.6 (5), p.767-774

2010

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Corrigendum: The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Scientific reports, 2016-07, Vol.6, p.30667-30667

2016

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Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death

Biochimica et biophysica acta, 2013-03, Vol.1830 (3), p.2562-2573

2013

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Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts

PloS one, 2012-08, Vol.7 (8), p.e42151-e42151

2012

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A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

CANCER RESEARCH, 2014, Vol.74 (19)

2014

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Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Targeting Mitochondrial Function to Treat Quiescent Tumor Cells in Solid Tumors

Iron chelators target both proliferating and quiescent cancer cells

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage

Cytokeratin-18 Is a Useful Serum Biomarker for Early Determination of Response of Breast Carcinomas to Chemotherapy

MYC is downregulated by a mitochondrial checkpoint mechanism

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition

Screening of natural products for therapeutic activity against solid tumors

Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: is acute apoptosis an "off-target" effect?

Utilization of cytokeratin-based biomarkers for pharmacodynamic studies

Restriction of cisplatin induction of acute apoptosis to a subpopulation of cells in a three‐dimensional carcinoma culture model

HER2-positive tumors imaged within 1 hour using a site-specifically 11C-labeled Sel-tagged affibody molecule

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis

Corrigendum: The proteasome deubiquitinase inhibitor VLX1570 shows selectivity for ubiquitin-specific protease-14 and induces apoptosis of multiple myeloma cells

Site-specifically 11C-labeled Sel-tagged annexin A5 and a size-matched control for dynamic in vivo PET imaging of protein distribution in tissues prior to and after induced cell death

Combining [11C]-AnxA5 PET imaging with serum biomarkers for improved detection in live mice of modest cell death in human solid tumor xenografts

A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

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