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Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon

Cancer research (Chicago, Ill.), 2017-06, Vol.77 (12), p.3352-3363

2017

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Tellu - an object-detector algorithm for automatic classification of intestinal organoids

Disease models & mechanisms, 2023-03, Vol.16 (3)

2023

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Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth

Disease models & mechanisms, 2023-04, Vol.16 (4)

2023

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In vivo modulation of endogenous gene expression via CRISPR/Cas9-mediated 3’UTR editing

Heliyon, 2023-03, Vol.9 (3), p.e13844-e13844, Article e13844

2023

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Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice

PloS one, 2013-10, Vol.8 (10), p.e76865-e76865

2013

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Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers

Cancer research (Chicago, Ill.), 2006-01, Vol.66 (2), p.659-664

2006

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Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

The Journal of clinical investigation, 2018-01, Vol.128 (1), p.402-414

2018

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PDPR Gene Variants Predisposing to Papillary Thyroid Cancer

Thyroid (New York, N.Y.), 2024-05, Vol.34 (5), p.575-582

2024

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Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5

Gastroenterology (New York, N.Y. 1943), 2023-10, Vol.165 (4), p.861-873

2023

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SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling

Nature communications, 2015-11, Vol.6 (1), p.8979-8979, Article 8979

2015

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Abstract 712: Mechanisms of stromal Lkb1 loss induced tumorigenesis in mouse models of Peutz-Jeghers syndrome

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.712-712

2016

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Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation

iScience, 2024-10, p.111246, Article 111246

2024

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The tumor suppressor kinase LKB1: lessons from mouse models

Journal of molecular cell biology, 2011-12, Vol.3 (6), p.330-340

2011

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Abstract 4857: Clonal expansion of Lkb1-deficient stromal cells underlies polyp development in mouse models of Peutz-Jeghers syndrome

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4857-4857

2014

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Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

The Journal of clinical investigation, 2018-01, Vol.128 (1), p.402

2018

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Mechanisms of pathogenicity in human MSH2 missense mutants

Human mutation, 2008-11, Vol.29 (11), p.1355-1363

2008

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Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR)

Human mutation, 2007-07, Vol.28 (7), p.683-693

2007

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Abstract C55: Investigating mechanisms of gastrointestinal polyposis and osteoblastic tumor formation induced by mesenchymal Lkb1 deficiency

Cancer research (Chicago, Ill.), 2013-10, Vol.73 (19_Supplement), p.C55-C55

2013

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Pathogenicity of MSH2 Missense Mutations Is Typically Associated With Impaired Repair Capability of the Mutated Protein

Gastroenterology (New York, N.Y. 1943), 2006-11, Vol.131 (5), p.1408-1417

2006

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Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification

International journal of cancer, 2008-08, Vol.123 (3), p.720-724

2008

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SUMOylation of AMPK[alpha]1 by PIAS4 specifically regulates mTORC1 signalling

Nature communications, 2015-11, Vol.6, p.8979

2015

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Cancer-Predicting Gene Expression Changes in Colonic Mucosa of Western Diet Fed Mlh1+/- Mice: e76865

PloS one, 2013-10, Vol.8 (10)

2013

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A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance—functional analysis reveals the pathogenic one

Familial cancer, 2011-09, Vol.10 (3), p.515-520

2011

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The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC

International journal of oncology, 2006, Vol.28 (1), p.149-153

2006

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The risk of developing type 2 diabetes after gestational diabetes: A registry study from Finland

Diabetes epidemiology and management, 2023-04, Vol.10, p.100124, Article 100124

2023

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Western Diet Deregulates Bile Acid Homeostasis, Cell Proliferation, and Tumorigenesis in Colon

Tellu - an object-detector algorithm for automatic classification of intestinal organoids

Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth

In vivo modulation of endogenous gene expression via CRISPR/Cas9-mediated 3’UTR editing

Cancer-predicting gene expression changes in colonic mucosa of Western diet fed Mlh1+/- mice

Gene conversion is a frequent mechanism of inactivation of the wild-type allele in cancers from MLH1/MSH2 deletion carriers

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

PDPR Gene Variants Predisposing to Papillary Thyroid Cancer

Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5

SUMOylation of AMPKα1 by PIAS4 specifically regulates mTORC1 signalling

Abstract 712: Mechanisms of stromal Lkb1 loss induced tumorigenesis in mouse models of Peutz-Jeghers syndrome

Mesenchymal GDNF promotes intestinal enterochromaffin cell differentiation

The tumor suppressor kinase LKB1: lessons from mouse models

Abstract 4857: Clonal expansion of Lkb1-deficient stromal cells underlies polyp development in mouse models of Peutz-Jeghers syndrome

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

Mechanisms of pathogenicity in human MSH2 missense mutants

Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR)

Abstract C55: Investigating mechanisms of gastrointestinal polyposis and osteoblastic tumor formation induced by mesenchymal Lkb1 deficiency

Pathogenicity of MSH2 Missense Mutations Is Typically Associated With Impaired Repair Capability of the Mutated Protein

Uncertain pathogenicity of MSH2 variants N127S and G322D challenges their classification

SUMOylation of AMPK[alpha]1 by PIAS4 specifically regulates mTORC1 signalling

Cancer-Predicting Gene Expression Changes in Colonic Mucosa of Western Diet Fed Mlh1+/- Mice: e76865

A putative Lynch syndrome family carrying MSH2 and MSH6 variants of uncertain significance—functional analysis reveals the pathogenic one

The importance of functional testing in the genetic assessment of Muir-Torre syndrome, a clinical subphenotype of HNPCC

The risk of developing type 2 diabetes after gestational diabetes: A registry study from Finland

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