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Evaluation of the Success of High-Throughput Physiologically Based Pharmacokinetic (HT-PBPK) Modeling Predictions to Inform Early Drug Discovery
Molecular pharmaceutics, 2022-07, Vol.19 (7), p.2203-2216
2022
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Can We Predict Clinical Pharmacokinetics of Highly Lipophilic Compounds by Integration of Machine Learning or In Vitro Data into Physiologically Based Models? A Feasibility Study Based on 12 Development Compounds
Molecular pharmaceutics, 2022-11, Vol.19 (11), p.3858-3868
2022
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A Machine Learning Framework to Improve Rat Clearance Predictions and Inform Physiologically Based Pharmacokinetic Modeling
Molecular pharmaceutics, 2023-10, Vol.20 (10), p.5052-5065
2023
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A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models
CPT: pharmacometrics and systems pharmacology, 2023-03, Vol.12 (3), p.346-359
2023
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Investigation of simplified physiologically‐based pharmacokinetic models in rat and human
CPT: pharmacometrics and systems pharmacology, 2023-03, Vol.12 (3), p.333-345
2023
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Animal versus human oral drug bioavailability: Do they correlate?
European journal of pharmaceutical sciences, 2014-06, Vol.57 (100), p.280-291
2014
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Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report
The AAPS journal, 2019-02, Vol.21 (2), p.29-29, Article 29
2019
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Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution
The AAPS journal, 2020-02, Vol.22 (2), p.41, Article 41
2020
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Importance of target-mediated drug disposition for small molecules
Drug discovery today, 2018-12, Vol.23 (12), p.2023-2030
2018
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Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption
The AAPS journal, 2015-09, Vol.17 (5), p.1177-1192
2015
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Analysis of the impact of controlled release formulations on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model
European journal of pharmaceutical sciences, 2015-01, Vol.67, p.32-44
2015
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Impact of target interactions on small-molecule drug disposition: an overlooked area
Nature reviews. Drug discovery, 2018-04, Vol.17 (4), p.299-299
2018
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Pediatric Pharmacokinetics and Dose Predictions: A Report of a Satellite Meeting to the 10th Juvenile Toxicity Symposium
Clinical and translational science, 2021-01, Vol.14 (1), p.29-35
2021
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The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data
Pharmaceutical research, 2014-03, Vol.31 (3), p.720-730
2014
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Real‐World Data and Physiologically‐Based Mechanistic Models for Precision Medicine
Clinical pharmacology and therapeutics, 2020-04, Vol.107 (4), p.694-696
2020
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LipMetE (Lipophilic Metabolism Efficiency) as a Simple Guide for Half-Life and Dosing Regimen Prediction of Oral Drugs
ACS medicinal chemistry letters, 2022-09, Vol.13 (9), p.1444-1451
2022
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Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin
The AAPS journal, 2016-11, Vol.18 (6), p.1532-1549
2016
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Correction to: Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry Perspective
The AAPS journal, 2020-11, Vol.23 (1), p.6, Article 6
2020
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Prediction of Oral Drug Bioavailability: From Animal-Based Extrapolation Towards the Application of Physiologically-Based Pharmacokinetic Modelling and Simulation
2016
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The Interplay Between Drug Release and Intestinal Gut‐Wall Metabolism
Oral Drug Delivery for Modified Release Formulations, 2022, p.65-86
2022
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