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Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity

The Journal of pharmacology and experimental therapeutics, 2019-02, Vol.368 (2), p.299-307

2019

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Enteric RET inhibition attenuates gastrointestinal secretion and motility via cholinergic signaling in rat colonic mucosal preparations

Neurogastroenterology and motility, 2019-04, Vol.31 (4), p.e13479-n/a

2019

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The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

Annual review of pharmacology and toxicology, 1997-01, Vol.37 (1), p.143-166

1997

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Signaling pathways in apoptosis as potential targets for cancer therapy

Trends in Cell Biology, 2001-08, Vol.11 (8), p.343-348

2001

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Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation

Assay and drug development technologies, 2013-06, Vol.11 (5), p.308-325

2013

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Cell, 1994-04, Vol.77 (2), p.175-178

1994

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Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity

Molecular cancer therapeutics, 2005-05, Vol.4 (5), p.751-760

2005

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Farnesyltransferase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospects

Seminars in cancer biology, 2000-12, Vol.10 (6), p.443-452

2000

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Farnesyltransferase inhibitors: targeting the molecular basis of cancer

Biochimica et biophysica acta. Reviews on cancer, 1999-05, Vol.1423 (3), p.C19-C30

Oliff, Allen

1999

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TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis

Blood advances, 2017-12, Vol.1 (26), p.2553-2562

2017

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Farnesyl Transferase Inhibitors Cause Enhanced Mitotic Sensitivity to Taxol and Epothilones

Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (4), p.1369-1374

1998

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A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

Nature medicine, 2000-11, Vol.6 (11), p.1248-1252

2000

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A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

Molecular and Cellular Biology, 1998-01, Vol.18 (1), p.85-92

1998

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PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites

Drug metabolism and disposition, 2001-03, Vol.29 (3), p.313

2001

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Identification and Optimization of Novel Small c‑Abl Kinase Activators Using Fragment and HTS Methodologies

Journal of medicinal chemistry, 2019-02, Vol.62 (4), p.2154-2171

2019

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Tumors secreting human TNF/cachectin induce cachexia in mice

Cell, 1987-08, Vol.50 (4), p.555-563

1987

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Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors

ACS medicinal chemistry letters, 2021-06, Vol.12 (6), p.1005-1010

2021

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A Prostate-specific Antigen (PSA)-activated Vinblastine Prodrug Selectively Kills PSA-secreting Cells in Vivo

Molecular cancer therapeutics, 2002-05, Vol.1 (7), p.451

2002

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Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.725-732

1994

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Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase

Journal of medicinal chemistry, 1999-08, Vol.42 (17), p.3356-3368

1999

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Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

Bioorganic & medicinal chemistry letters, 1999-12, Vol.9 (23), p.3301-3306

1999

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Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.623-628

2018

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Mo1602 - Identification of a Ret Kinase Inhibitor, GSK589, as a Peripheral Analgesic for the Treatment Visceral Pain Associated with Irritable Bowel Syndrome

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S731-S731

2017

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Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Cancer research (Chicago, Ill.), 2001-12, Vol.61 (24), p.8758-8768

2001

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Identification of a Ret Kinase Inhibitor, GSK589, as a Peripheral Analgesic for the Treatment Visceral Pain Associated with Irritable Bowel Syndrome

Gastroenterology (New York, N.Y. 1943), 2017-04, Vol.152 (5), p.S731-S731

2017

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Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity

Enteric RET inhibition attenuates gastrointestinal secretion and motility via cholinergic signaling in rat colonic mucosal preparations

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

Signaling pathways in apoptosis as potential targets for cancer therapy

Development of a high-throughput screen to detect inhibitors of TRPS1 sumoylation

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Matrix metalloproteinase–activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity

Farnesyltransferase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospects

Farnesyltransferase inhibitors: targeting the molecular basis of cancer

TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis

Farnesyl Transferase Inhibitors Cause Enhanced Mitotic Sensitivity to Taxol and Epothilones

A peptide-doxorubicin 'prodrug' activated by prostate-specific antigen selectively kills prostate tumor cells positive for prostate-specific antigen in vivo

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

PSA-specific and non-PSA-specific conversion of a PSA-targeted peptide conjugate of doxorubicin to its active metabolites

Identification and Optimization of Novel Small c‑Abl Kinase Activators Using Fragment and HTS Methodologies

Tumors secreting human TNF/cachectin induce cachexia in mice

Discovery of Orally Bioavailable Ligand Efficient Quinazolindiones as Potent and Selective Tankyrases Inhibitors

A Prostate-specific Antigen (PSA)-activated Vinblastine Prodrug Selectively Kills PSA-secreting Cells in Vivo

Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase

Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase

Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS

Mo1602 - Identification of a Ret Kinase Inhibitor, GSK589, as a Peripheral Analgesic for the Treatment Visceral Pain Associated with Irritable Bowel Syndrome

Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Identification of a Ret Kinase Inhibitor, GSK589, as a Peripheral Analgesic for the Treatment Visceral Pain Associated with Irritable Bowel Syndrome

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