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Improving the Nicotinic Pharmacophore with a Series of (Isoxazole)methylene-1-azacyclic Compounds: Synthesis, Structure−Activity Relationship, and Molecular Modeling

Journal of medicinal chemistry, 1999-12, Vol.42 (24), p.4970-4980

1999

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Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors

The Journal of pharmacology and experimental therapeutics, 1994-04, Vol.269 (1), p.271

1994

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Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

Journal of medicinal chemistry, 1992-06, Vol.35 (12), p.2274-2283

1992

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Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

European journal of pharmacology, 1998-09, Vol.356 (2), p.109-119

1998

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Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232)

The Journal of pharmacology and experimental therapeutics, 1994-04, Vol.269 (1), p.282

1994

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Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity

Journal of medicinal chemistry, 1998-10, Vol.41 (22), p.4378-4384

1998

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Bioisosteric replacement strategy for the synthesis of 1-azacyclic compounds with high affinity for the central nicotinic cholinergic receptors

Bioorganic & medicinal chemistry, 2000-06, Vol.8 (6), p.1443-1450

2000

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Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Journal of medicinal chemistry, 1997-02, Vol.40 (4), p.538-546

1997

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Pleurodesis with polidocanol in pigs. An experimental study

Chest, 1994-03, Vol.105 (3), p.908-910

1994

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The use of bioisosteric groups in lead optimization

Current opinion in drug discovery & development, 2001-07, Vol.4 (4), p.471

Olesen, P H

2001

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Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation

Bioorganic & medicinal chemistry letters, 1998-10, Vol.8 (20), p.2897-2902

1998

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Fate of circulating amino-terminal propeptide of type III procollagen in conscious pigs

American journal of physiology. Regulatory, integrative and comparative physiology, 1993-07, Vol.265 (1), p.139-R145

1993

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An improved nicotinic pharmacophore and a stereoselective CoMFA-model for nicotinic agonists acting at the central nicotinic acetylcholine receptors labelled by [3H]-N-methylcarbamylcholine

Journal of computer-aided molecular design, 2001-03, Vol.15 (3), p.247

2001

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1,2,5-Thiadiazole Analogues of Aceclidine as Potent m1 Muscarinic Agonists

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.379-392

1998

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3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles. Structure—activity relationships for antinociception mediated by central muscarinic receptors

European journal of medicinal chemistry, 1996, Vol.31 (3), p.221-230

1996

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Potential role of muscarinic receptors in schizophrenia

Life sciences (1973), 1999, Vol.64 (6), p.527-534

1999

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Lymphatic clearance of synovial fluid in conscious pigs: the aminoterminal propeptide of type III procollagen

European journal of clinical investigation, 1993-12, Vol.23 (12), p.778-784

1993

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Autologous fibrin sealant in reconstructive rabbit oviduct microsurgery

Fertility and sterility, 1990-07, Vol.54 (1), p.157-160

1990

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Macromolecular prodrugs. XVI: Colon-targeted delivery ― Comparison of the rate of release of naproxen from dextran ester prodrugs in homogenates of various segments of the pig gastrointestinal (GI) tract

Pharmaceutical research, 1989-12, Vol.6 (12), p.995-999

1989

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Synthesis and in Vitro Characterization of 1-(4-Aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic Acid Derivatives. A New Class of Selective GSK-3 Inhibitors

Journal of medicinal chemistry, 2003-07, Vol.46 (15), p.3333-3341

2003

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1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.02,6]heptanes as New Potent Muscarinic M1 Agonists: Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

Journal of medicinal chemistry, 1999-06, Vol.42 (11), p.1999-2006

1999

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Cardiovascular effects of pregnanolone emulsion: an experimental study in artificially ventilated dogs

Acta anaesthesiologica Scandinavica, 1991-10, Vol.35 (7), p.669-675

1991

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Histomorphological evaluation of wound healing of rabbit oviduct after microsurgical reanastomosis with the use of autologous fibrin adhesive, human fibrin adhesive or poly-glycolic acid suture

European surgical research, 1993, Vol.25 (5), p.278-286

1993

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Anaerobic bacteria in rheumatoid arthritis

Annals of the rheumatic diseases, 1990-07, Vol.49 (7), p.568-568

1990

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3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: a novel class of central nicotinic receptor ligands

Bioorganic & medicinal chemistry, 1998-09, Vol.6 (9), p.1623-1629

1998

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Improving the Nicotinic Pharmacophore with a Series of (Isoxazole)methylene-1-azacyclic Compounds: Synthesis, Structure−Activity Relationship, and Molecular Modeling

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232)

Muscarinic Agonists with Antipsychotic-like Activity: Structure−Activity Relationships of 1,2,5-Thiadiazole Analogues with Functional Dopamine Antagonist Activity

Bioisosteric replacement strategy for the synthesis of 1-azacyclic compounds with high affinity for the central nicotinic cholinergic receptors

Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Pleurodesis with polidocanol in pigs. An experimental study

The use of bioisosteric groups in lead optimization

Identification of side chains on 1,2,5-thiadiazole-azacycles optimal for muscarinic M1 receptor activation

Fate of circulating amino-terminal propeptide of type III procollagen in conscious pigs

An improved nicotinic pharmacophore and a stereoselective CoMFA-model for nicotinic agonists acting at the central nicotinic acetylcholine receptors labelled by [3H]-N-methylcarbamylcholine

1,2,5-Thiadiazole Analogues of Aceclidine as Potent m1 Muscarinic Agonists

3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles. Structure—activity relationships for antinociception mediated by central muscarinic receptors

Potential role of muscarinic receptors in schizophrenia

Lymphatic clearance of synovial fluid in conscious pigs: the aminoterminal propeptide of type III procollagen

Autologous fibrin sealant in reconstructive rabbit oviduct microsurgery

Macromolecular prodrugs. XVI: Colon-targeted delivery ― Comparison of the rate of release of naproxen from dextran ester prodrugs in homogenates of various segments of the pig gastrointestinal (GI) tract

Synthesis and in Vitro Characterization of 1-(4-Aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic Acid Derivatives. A New Class of Selective GSK-3 Inhibitors

1-(1,2,5-Thiadiazol-4-yl)-4-azatricyclo[2.2.1.02,6]heptanes as New Potent Muscarinic M1 Agonists: Structure−Activity Relationship for 3-Aryl-2-propyn-1-yloxy and 3-Aryl-2-propyn-1-ylthio Derivatives

Cardiovascular effects of pregnanolone emulsion: an experimental study in artificially ventilated dogs

Histomorphological evaluation of wound healing of rabbit oviduct after microsurgical reanastomosis with the use of autologous fibrin adhesive, human fibrin adhesive or poly-glycolic acid suture

Anaerobic bacteria in rheumatoid arthritis

3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: a novel class of central nicotinic receptor ligands

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