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Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Molecular cell, 2015-05, Vol.58 (3), p.440-452

2015

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Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2013-01, Vol.56 (1), p.15-30

2013

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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (9), p.3401-3406

2014

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Structural biology of the Bcl-2 family of proteins

BBA - Molecular Cell Research, 2004-03, Vol.1644 (2), p.83-94

2004

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Journal of medicinal chemistry, 2004-08, Vol.47 (18), p.4417-4426

2004

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Nature (London), 2000-12, Vol.408 (6815), p.1004-1008

2000

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ALARM NMR: A Rapid and Robust Experimental Method To Detect Reactive False Positives in Biochemical Screens

Journal of the American Chemical Society, 2005-01, Vol.127 (1), p.217-224

2005

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Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein

Biochemistry (Easton), 2004-05, Vol.43 (20), p.6059-6063

2004

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Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS

Proceedings of the National Academy of Sciences - PNAS, 2007-05, Vol.104 (19), p.7875-7880

2007

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Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

Journal of medicinal chemistry, 2001-04, Vol.44 (8), p.1202-1210

2001

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A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia

Cancer discovery, 2018-12, Vol.8 (12), p.1566-1581

2018

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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

Angewandte Chemie (International ed.), 2012-06, Vol.51 (25), p.6140-6143

International ed. in English, 2012

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Defining the p53 DNA‐binding domain/Bcl‐xL‐binding interface using NMR

FEBS letters, 2004-02, Vol.559 (1-3), p.171-174

2004

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Integrative Genomic Analysis of Small-Cell Lung Carcinoma Reveals Correlates of Sensitivity to Bcl-2 Antagonists and Uncovers Novel Chromosomal Gains

Molecular cancer research, 2007-04, Vol.5 (4), p.331-339

2007

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Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.2054-2066

2016

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Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2020-04, Vol.63 (8), p.4315-4333

2020

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Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

Journal of medicinal chemistry, 2020-08, Vol.63 (15), p.8325-8337

2020

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Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex

Biochemistry (Easton), 2020-03, Vol.59 (8), p.964-969

2020

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Solution Structure of a Bcl-2 Homolog from Kaposi Sarcoma Virus

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (6), p.3428-3433

2002

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Fragment-based screening of programmed death ligand 1 (PD-L1)

Bioorganic & medicinal chemistry letters, 2019-03, Vol.29 (6), p.786-790

2019

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SOS-NMR: A Saturation Transfer NMR-Based Method for Determining the Structures of Protein−Ligand Complexes

Journal of the American Chemical Society, 2004-03, Vol.126 (8), p.2390-2398

2004

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Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia‑1 Inhibitors Using Structure-Based Design

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2410-2421

2018

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Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2018-07, Vol.61 (13), p.5623-5642

2018

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Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

Biochemistry (Easton), 2009-03, Vol.48 (9), p.1870-1877

2009

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Discovery of Tricyclic Indoles That Potently Inhibit Mcl‑1 Using Fragment-Based Methods and Structure-Based Design

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3794-3805

2015

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Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

Structural biology of the Bcl-2 family of proteins

Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

ALARM NMR: A Rapid and Robust Experimental Method To Detect Reactive False Positives in Biochemical Screens

Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein

Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia

Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation

Defining the p53 DNA‐binding domain/Bcl‐xL‐binding interface using NMR

Integrative Genomic Analysis of Small-Cell Lung Carcinoma Reveals Correlates of Sensitivity to Bcl-2 Antagonists and Uncovers Novel Chromosomal Gains

Discovery of 2‑Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods

Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design

Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods

Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex

Solution Structure of a Bcl-2 Homolog from Kaposi Sarcoma Virus

Fragment-based screening of programmed death ligand 1 (PD-L1)

SOS-NMR: A Saturation Transfer NMR-Based Method for Determining the Structures of Protein−Ligand Complexes

Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia‑1 Inhibitors Using Structure-Based Design

Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Structural Characterization of a Soluble Amyloid β-Peptide Oligomer

Discovery of Tricyclic Indoles That Potently Inhibit Mcl‑1 Using Fragment-Based Methods and Structure-Based Design

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