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Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology

Trends in parasitology, 2021-06, Vol.37 (6), p.476-492

2021

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Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

Nature communications, 2020-09, Vol.11 (1), p.4813-4813, Article 4813

2020

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Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

PLoS pathogens, 2022-10, Vol.18 (10), p.e1010926

2022

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Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

Nature communications, 2023-05, Vol.14 (1), p.3059-3059, Article 3059

2023

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4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

Journal of medicinal chemistry, 2017-12, Vol.60 (24), p.10245-10256

2017

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Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery

Accounts of chemical research, 2017-07, Vol.50 (7), p.1606-1616

2017

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Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

mBio, 2024-01, Vol.15 (1), p.e0183223-e0183223

2024

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Recent updates in the discovery and development of novel antimalarial drug candidates

MedChemComm, 2018-03, Vol.9 (3), p.437-453

2018

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In Vitro Activity of Antifolate and Polymorphism in Dihydrofolate Reductase of Plasmodium falciparum Isolates from the Kenyan Coast: Emergence of Parasites with Ile-164-Leu Mutation

Antimicrobial Agents and Chemotherapy, 2009-09, Vol.53 (9), p.3793-3798

2009

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Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya

Antimicrobial Agents and Chemotherapy, 2012-02, Vol.56 (2), p.1105-1107

2012

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Repeat Polymorphisms in the Low-Complexity Regions of Plasmodium falciparum ABC Transporters and Associations with In Vitro Antimalarial Responses

Antimicrobial Agents and Chemotherapy, 2013-12, Vol.57 (12), p.6196-6204

2013

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A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya

PloS one, 2014-05, Vol.9 (5), p.e96486-e96486

2014

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In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya

Antimicrobial Agents and Chemotherapy, 2010-08, Vol.54 (8), p.3302-3307

2010

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Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4445-4467

2020

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Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya

International journal for parasitology -- drugs and drug resistance, 2014-12, Vol.4 (3), p.152-163

2014

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Towards next-generation treatment options to combat Plasmodium falciparum malaria

Nature reviews. Microbiology, 2024-10

2024

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Anticancer agents against malaria: time to revisit?

Trends in parasitology, 2010-03, Vol.26 (3), p.125-129

2010

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Early metabolic profiling of pyrido[1,2-a]benzimidazoles in mouse liver microsomes by LC-MS/MS

Drug metabolism and pharmacokinetics, 2017-01, Vol.32 (1), p.S48-S48

2017

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The Polymorphic Linker Domain of pfmdr1 Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa

Antimicrobial Agents and Chemotherapy, 2013-09, Vol.57 (9), p.4595-4598

2013

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Antiplasmodial drug targets: a patent review (2000 - 2013)

Expert opinion on therapeutic patents, 2016-01, Vol.26 (1), p.107-130

2016

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Pyronaridine-artesunate Shows Promise as an Effective and Well-tolerated Treatment for Artemisinin-resistant Plasmodium falciparum Malaria

Clinical infectious diseases, 2020-05, Vol.70 (10), p.2196-2198

2020

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Correction: Recent updates in the discovery and development of novel antimalarial drug candidates

MedChemComm, 2018-03, Vol.9 (3), p.59-59

2018

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Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

Nature (London), 2019-12, Vol.576 (7786), p.315-320

2019

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Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity

Bioorganic & medicinal chemistry, 2020-07, Vol.28 (13), p.115530-115530, Article 115530

2020

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Malaria in the Era of Food Fortification With Folic Acid

Food and nutrition bulletin, 2016-06, Vol.37 (2), p.153-163

2016

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Genomic and Genetic Approaches to Studying Antimalarial Drug Resistance and Plasmodium Biology

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery

Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered Plasmodium falciparum physiology

Recent updates in the discovery and development of novel antimalarial drug candidates

In Vitro Activity of Antifolate and Polymorphism in Dihydrofolate Reductase of Plasmodium falciparum Isolates from the Kenyan Coast: Emergence of Parasites with Ile-164-Leu Mutation

Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya

Repeat Polymorphisms in the Low-Complexity Regions of Plasmodium falciparum ABC Transporters and Associations with In Vitro Antimalarial Responses

A genome wide association study of Plasmodium falciparum susceptibility to 22 antimalarial drugs in Kenya

In Vitro Activities of Quinine and Other Antimalarials and pfnhe Polymorphisms in Plasmodium Isolates from Kenya

Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya

Towards next-generation treatment options to combat Plasmodium falciparum malaria

Anticancer agents against malaria: time to revisit?

Early metabolic profiling of pyrido[1,2-a]benzimidazoles in mouse liver microsomes by LC-MS/MS

The Polymorphic Linker Domain of pfmdr1 Is Associated with Resistance-Conferring Mutations in Plasmodium falciparum Populations from East and West Africa

Antiplasmodial drug targets: a patent review (2000 - 2013)

Pyronaridine-artesunate Shows Promise as an Effective and Well-tolerated Treatment for Artemisinin-resistant Plasmodium falciparum Malaria

Correction: Recent updates in the discovery and development of novel antimalarial drug candidates

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity

Malaria in the Era of Food Fortification With Folic Acid

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