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Structure-Based Design and Evaluation of Naphthalene Diimide G‑Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

Journal of medicinal chemistry, 2013-04, Vol.56 (7), p.2959-2974

2013

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Direct arylations on water: synthesis of 2,5-disubstituted oxazoles balsoxin and texaline

Chemical communications (Cambridge, England), 2008-03 (10), p.1241-1243

2008

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Small-molecule quadruplex-targeted drug discovery

Bioorganic & medicinal chemistry letters, 2014-06, Vol.24 (12), p.2602-2612

2014

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KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

Scientific reports, 2015-04, Vol.5 (1), p.9696-9696, Article 9696

2015

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Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

PloS one, 2015-05, Vol.10 (5), p.e0126891-e0126891

2015

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Macrocyclic naphthalene diimides as G-quadruplex binders

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3819-3830

2015

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Discovery of new G-quadruplex binding chemotypes

Chemical communications (Cambridge, England), 2014-01, Vol.50 (8), p.960-963

2014

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The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds

Bioorganic & medicinal chemistry, 2013-10, Vol.21 (20), p.6162-6170

2013

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Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex

ChemMedChem, 2015-05, Vol.10 (5), p.836-849

2015

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A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells

Scientific reports, 2020-07, Vol.10 (1), p.12192, Article 12192

2020

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Direct Arylations of 2H-Indazoles On Water

Organic letters, 2010-01, Vol.12 (2), p.224-226

2010

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Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G‑Quadruplex-Binding Small Molecule

Journal of medicinal chemistry, 2018-03, Vol.61 (6), p.2500-2517

2018

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A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

Scientific reports, 2015-06, Vol.5 (1), p.11385-11385, Article 11385

2015

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Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (19), p.5351-5355

2013

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Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology

ACS medicinal chemistry letters, 2020-05, Vol.11 (5), p.991-999

2020

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Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (18), p.5930-5935

2012

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Synthesis, G-Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains

ChemMedChem, 2013-10, Vol.8 (10), p.1648-1661

2013

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Synthesis and Initial in Vivo Studies with [11C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK‑3

ACS medicinal chemistry letters, 2015-05, Vol.6 (5), p.548-552

2015

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Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Synthesis (Stuttgart), 2012-02, Vol.2012 (4), p.635-647

2012

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Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds

Bioorganic & medicinal chemistry letters, 2004-11, Vol.14 (22), p.5465-5467

2004

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ChemInform Abstract: Small-Molecule Quadruplex-Targeted Drug Discovery

ChemInform, 2014-07, Vol.45 (28), p.no-no

2014

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Discovery of new G-quadruplex binding chemotypesElectronic supplementary information (ESI) available. See DOI: 10.1039/c3cc48616h

2013-12

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Direct Arylations of 2 H -Indazoles On Water

Organic letters, 2010-01, Vol.12 (2), p.224-226

2010

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Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework

Tetrahedron letters, 2004-07, Vol.45 (29), p.5661-5663

2004

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ChemInform Abstract: Synthesis, G-Quadruplex Stabilization, Docking Studies, and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains

ChemInform, 2014-02, Vol.45 (8), p.no-no

2014

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Structure-Based Design and Evaluation of Naphthalene Diimide G‑Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

Direct arylations on water: synthesis of 2,5-disubstituted oxazoles balsoxin and texaline

Small-molecule quadruplex-targeted drug discovery

KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

Macrocyclic naphthalene diimides as G-quadruplex binders

Discovery of new G-quadruplex binding chemotypes

The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds

Indolo[3,2-c]quinoline G-Quadruplex Stabilizers: a Structural Analysis of Binding to the Human Telomeric G-Quadruplex

A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells

Direct Arylations of 2H-Indazoles On Water

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G‑Quadruplex-Binding Small Molecule

A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer

Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands

Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology

Sequences in the HSP90 promoter form G-quadruplex structures with selectivity for disubstituted phenyl bis-oxazole derivatives

Synthesis, G-Quadruplex Stabilisation, Docking Studies, and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains

Synthesis and Initial in Vivo Studies with [11C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK‑3

Scale-Up of Flow-Assisted Synthesis of C2-Symmetric Chiral PyBox Ligands

Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds

ChemInform Abstract: Small-Molecule Quadruplex-Targeted Drug Discovery

Discovery of new G-quadruplex binding chemotypesElectronic supplementary information (ESI) available. See DOI: 10.1039/c3cc48616h

Direct Arylations of 2 H -Indazoles On Water

Solid-phase Suzuki cross-coupling reactions using a phosphine ligand based on a phospha-adamantane framework

ChemInform Abstract: Synthesis, G-Quadruplex Stabilization, Docking Studies, and Effect on Cancer Cells of Indolo[3,2-b]quinolines with One, Two, or Three Basic Side Chains

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