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Weak affinity chromatography as a new approach for fragment screening in drug discovery

Analytical biochemistry, 2011-07, Vol.414 (1), p.138-146

2011

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Pharmaceutical modulation of the proteolytic profile of Transforming Growth Factor Beta induced protein (TGFBIp) offers a new avenue for treatment of TGFBI-corneal dystrophy

Journal of advanced research, 2020-07, Vol.24, p.529-543

2020

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Monitoring of influenza virus hemagglutinin in process samples using weak affinity ligands and surface plasmon resonance

Analytica chimica acta, 2008-08, Vol.623 (1), p.66-75

2008

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Designing transient binding drugs: A new concept for drug discovery

Drug discovery today, 2008-05, Vol.13 (9), p.433-439

Ohlson, Sten

2008

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Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90)

Bioorganic & medicinal chemistry letters, 2018-05, Vol.28 (8), p.1357-1362

2018

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Fragment screening for drug leads by weak affinity chromatography (WAC-MS)

Methods (San Diego, Calif.), 2018-08, Vol.146, p.26-38

2018

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Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat

Journal of medicinal chemistry, 2017-10, Vol.60 (20), p.8336-8357

2017

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Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6)

Bioorganic & medicinal chemistry letters, 2018-08, Vol.28 (15), p.2636-2640

2018

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Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands

Biochimica et biophysica acta, 1999-10, Vol.1472 (1), p.262-269

1999

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Lectin affinity capillary electrophoresis in glycoform analysis applying the partial filling technique

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004-10, Vol.809 (2), p.323-329

2004

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Platelet lysate: a replacement for fetal bovine serum in animal cell culture?

Cytotechnology (Dordrecht), 2003-01, Vol.42 (2), p.67-74

2003

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Fragment Screening by Weak Affinity Chromatography: Comparison with Established Techniques for Screening against HSP90

Analytical chemistry (Washington), 2013-07, Vol.85 (14), p.6756-6766

2013

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Fragment screening of cyclin G-associated kinase by weak affinity chromatography

Analytical and bioanalytical chemistry, 2012-11, Vol.404 (8), p.2417-2425

2012

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Direct analysis – no sample preparation – of bioavailable cortisol in human plasma by weak affinity chromatography (WAC)

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2017-09, Vol.1061-1062, p.438-444

2017

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Lectin affinity capillary electrophoresis in glycoform analysis applying the partial filling technique

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004-10, Vol.809 (2), p.323-329

2004

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Combining weak affinity chromatography, NMR spectroscopy and molecular simulations in carbohydrate-lysozyme interaction studies

Organic & biomolecular chemistry, 2012-01, Vol.10 (15), p.3019-3032

2012

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Comparison of weak affinity chromatography and surface plasmon resonance in determining affinity of small molecules

Analytical biochemistry, 2014-09, Vol.461, p.57-59

2014

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Combining weak affinity chromatography, NMR spectroscopy and molecular simulations in carbohydratelysozyme interaction studiesElectronic supplementary information (ESI) available. Experimental details, characterizations and additional results. See DOI: 10.1039/c2ob07066a

2012-03

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Synthesis, Biological Evaluation, WAC and NMR Studies of S-Galactosides and Non-Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate Moieties

Chemistry : a European journal, 2013-12, Vol.19 (52), p.17989-18003

2013

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Lipodisks integrated with weak affinity chromatography enable fragment screening of integral membrane proteinsElectronic supplementary information (ESI) available: Characterization of the structure, size, and lipid and protein content of the proteolipodisks; list of compounds screened by WAC, and the results from the chromatography experiments. See DOI: 10.1039/c5an02105g

2016-01

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High-throughput fragment screening by affinity LC-MS

Journal of biomolecular screening, 2013-02, Vol.18 (2), p.160-171

2013

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Lipodisks integrated with weak affinity chromatography enable fragment screening of integral membrane proteins

Analyst (London), 2016-01, Vol.141 (3), p.981-988

2016

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Elucidating the selectivity of recombinant forms of Aleuria aurantia lectin using weak affinity chromatography

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012-02, Vol.885-886, p.66-72

2012

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Analysis of Protein Target Interactions of Synthetic Mixtures by Affinity-LC/MS

SLAS discovery, 2017-04, Vol.22 (4), p.440-446

2017

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Immobilized lipodisks as model membranes in high-throughput HPLC-MS analysis

Analytical and bioanalytical chemistry, 2013-05, Vol.405 (14), p.4859-4869

2013

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Weak affinity chromatography as a new approach for fragment screening in drug discovery

Pharmaceutical modulation of the proteolytic profile of Transforming Growth Factor Beta induced protein (TGFBIp) offers a new avenue for treatment of TGFBI-corneal dystrophy

Monitoring of influenza virus hemagglutinin in process samples using weak affinity ligands and surface plasmon resonance

Designing transient binding drugs: A new concept for drug discovery

Design and synthesis of triple inhibitors of janus kinase (JAK), histone deacetylase (HDAC) and Heat Shock Protein 90 (HSP90)

Fragment screening for drug leads by weak affinity chromatography (WAC-MS)

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat

Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6)

Interactions between neutrophil gelatinase-associated lipocalin and natural lipophilic ligands

Lectin affinity capillary electrophoresis in glycoform analysis applying the partial filling technique

Platelet lysate: a replacement for fetal bovine serum in animal cell culture?

Fragment Screening by Weak Affinity Chromatography: Comparison with Established Techniques for Screening against HSP90

Fragment screening of cyclin G-associated kinase by weak affinity chromatography

Direct analysis – no sample preparation – of bioavailable cortisol in human plasma by weak affinity chromatography (WAC)

Lectin affinity capillary electrophoresis in glycoform analysis applying the partial filling technique

Combining weak affinity chromatography, NMR spectroscopy and molecular simulations in carbohydrate-lysozyme interaction studies

Comparison of weak affinity chromatography and surface plasmon resonance in determining affinity of small molecules

Combining weak affinity chromatography, NMR spectroscopy and molecular simulations in carbohydratelysozyme interaction studiesElectronic supplementary information (ESI) available. Experimental details, characterizations and additional results. See DOI: 10.1039/c2ob07066a

Synthesis, Biological Evaluation, WAC and NMR Studies of S-Galactosides and Non-Carbohydrate Ligands of Cholera Toxin Based on Polyhydroxyalkylfuroate Moieties

High-throughput fragment screening by affinity LC-MS

Lipodisks integrated with weak affinity chromatography enable fragment screening of integral membrane proteins

Elucidating the selectivity of recombinant forms of Aleuria aurantia lectin using weak affinity chromatography

Analysis of Protein Target Interactions of Synthetic Mixtures by Affinity-LC/MS

Immobilized lipodisks as model membranes in high-throughput HPLC-MS analysis

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