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Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment

Xenobiotica, 2020-09, Vol.50 (9), p.1023-1031

2020

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Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations

Xenobiotica, 2020-12, Vol.50 (12), p.1413-1422

2020

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Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator‐activated receptor‐alpha modulator, in rats and monkeys

Biopharmaceutics & drug disposition, 2019-01, Vol.40 (1), p.12-17

2019

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Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver

Xenobiotica, 2020-07, Vol.50 (7), p.769-775

2020

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Quantitative Determination of H2 in Human Blood by 22Ne-aided Gas Chromatography–Mass Spectrometry Using a Single Quadrupole Instrument

Analytical Sciences, 2020/10/10, Vol.36(10), pp.1231-1236

2020

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Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1

Drug metabolism and pharmacokinetics, 2020-08, Vol.35 (4), p.354-360

2020

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Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase

Journal of pharmacy and pharmacology, 2005-10, Vol.57 (10), p.1305-1311

2005

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Reducing bacterial counts around the abutment following professional mechanical plaque removal at the implant bridge: A randomized crossover comparison of removing or not removing the superstructure

Journal of prosthodontic research, 2021-01, Vol.65 (1), p.91-96

2021

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The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

Free radical biology & medicine, 2012-05, Vol.52 (10), p.2142-2150

2012

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Induction of oligodendrocyte differentiation from adult human fibroblast-derived induced pluripotent stem cells

In vitro cellular & developmental biology. Animal, 2011-08, Vol.47 (7), p.464-469

2011

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The HSP90 Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse Model of Systemic Lupus Erythematosus

PloS one, 2015-05, Vol.10 (5), p.e0127361

2015

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Brain Targeting of Acyl-CoA:Cholesterol O‑Acyltransferase‑1 Inhibitor K‑604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution

ACS omega, 2019-10, Vol.4 (16), p.16943-16955

2019

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Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy

Molecular cancer therapeutics, 2012-02, Vol.11 (2), p.475-484

2012

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Immunopanning selection of A2B5-positive cells increased the differentiation efficiency of induced pluripotent stem cells into oligodendrocytes

Neuroscience letters, 2011-02, Vol.489 (2), p.79-83

2011

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Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice

The European journal of neuroscience, 1998-03, Vol.10 (3), p.976-988

1998

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High-Resolution Three-Dimensional Computed Tomography Analysis of the Clinical Efficacy of Cultured Autogenous Periosteal Cells in Sinus Lift Bone Grafting

Clinical implant dentistry and related research, 2016-08, Vol.18 (4), p.707-716

2016

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FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism

Molecular cancer research, 2014-07, Vol.12 (7), p.1042-1054

2014

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Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Journal of epidemiology, 2017-09, Vol.27 (9), p.420-427

2017

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Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme

BioMed research international, 2014-01, Vol.2014, p.407026-9

2014

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Positive Association of Plasma Homocysteine Levels with Cardio-Ankle Vascular Index in a Prospective Study of Japanese Men from the General Population

Journal of Atherosclerosis and Thrombosis, 2016/06/01, Vol.23(6), pp.681-691

2016

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Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors

Clinical cancer research, 2018-12, Vol.24 (24), p.6396-6407

2018

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Substituent effects on the formation and nucleophile selectivity of ring-substituted phenonium ions in aqueous solution

Journal of physical organic chemistry, 2013-12, Vol.26 (12), p.970-976

2013

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Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

Journal of epidemiology, 2011, Vol.21 (3), p.223-235

2011

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Synthesis of highly deuterium-labeled ( R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma

Bioorganic & medicinal chemistry, 2009-03, Vol.17 (5), p.1911-1917

2009

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Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment

Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations

Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator‐activated receptor‐alpha modulator, in rats and monkeys

Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver

Quantitative Determination of H2 in Human Blood by 22Ne-aided Gas Chromatography–Mass Spectrometry Using a Single Quadrupole Instrument

Increased plasma concentrations of an antidyslipidemic drug pemafibrate co-administered with rifampicin or cyclosporine A in cynomolgus monkeys genotyped for the organic anion transporting polypeptide 1B1

Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase

Reducing bacterial counts around the abutment following professional mechanical plaque removal at the implant bridge: A randomized crossover comparison of removing or not removing the superstructure

The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells

Induction of oligodendrocyte differentiation from adult human fibroblast-derived induced pluripotent stem cells

The HSP90 Inhibitor Ganetespib Alleviates Disease Progression and Augments Intermittent Cyclophosphamide Therapy in the MRL/lpr Mouse Model of Systemic Lupus Erythematosus

Brain Targeting of Acyl-CoA:Cholesterol O‑Acyltransferase‑1 Inhibitor K‑604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution

Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy

Immunopanning selection of A2B5-positive cells increased the differentiation efficiency of induced pluripotent stem cells into oligodendrocytes

Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice

High-Resolution Three-Dimensional Computed Tomography Analysis of the Clinical Efficacy of Cultured Autogenous Periosteal Cells in Sinus Lift Bone Grafting

FGFR3 translocations in bladder cancer: differential sensitivity to HSP90 inhibition based on drug metabolism

Interactions between inflammatory gene polymorphisms and HTLV-I infection for total death, incidence of cancer, and atherosclerosis-related diseases among the Japanese population

Hypofractionated High-Dose Irradiation with Positron Emission Tomography Data for the Treatment of Glioblastoma Multiforme

Positive Association of Plasma Homocysteine Levels with Cardio-Ankle Vascular Index in a Prospective Study of Japanese Men from the General Population

Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors

Substituent effects on the formation and nucleophile selectivity of ring-substituted phenonium ions in aqueous solution

Profile of participants and genotype distributions of 108 polymorphisms in a cross-sectional study of associations of genotypes with lifestyle and clinical factors: a project in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study

Synthesis of highly deuterium-labeled ( R)-K-13675, PPAR α agonist, for use as an internal standard for low-level quantification of drugs in plasma

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