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Ceramide synthases at the centre of sphingolipid metabolism and biology

Biochemical journal, 2012-02, Vol.441 (3), p.789-802

2012

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Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

Cell, 2012-03, Vol.148 (5), p.988-1000

2012

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Advances in determining signaling mechanisms of ceramide and role in disease

Journal of lipid research, 2019-05, Vol.60 (5), p.913-918

2019

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Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death

Anti-cancer agents in medicinal chemistry, 2012-05, Vol.12 (4), p.340-363

2012

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Sphingolipids and their metabolism in physiology and disease

Nature reviews. Molecular cell biology, 2018-03, Vol.19 (3), p.175-191

2018

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Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors

Biochimica et biophysica acta, 2013-01, Vol.1831 (1), p.157-166

2013

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Evolving concepts in cancer therapy through targeting sphingolipid metabolism

Biochimica et biophysica acta, 2014-08, Vol.1841 (8), p.1174-1188

2014

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The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind

The Journal of biological chemistry, 2002-07, Vol.277 (29), p.25847-25850

2002

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Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (28), p.E5549-E5558

2017

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Murine Model for Colitis-Associated Cancer of the Colon

Methods in molecular biology (Clifton, N.J.), 2016-01, Vol.1438, p.245

2016

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A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation

PLoS genetics, 2011-05, Vol.7 (5), p.e1002063-e1002063

2011

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Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells

Scientific reports, 2021-04, Vol.11 (1), p.8259-8259, Article 8259

2021

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GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis

The EMBO journal, 2021-10, Vol.40 (20), p.e107766-n/a

2021

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1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase

Journal of lipid research, 2022-01, Vol.63 (1), p.100154, Article 100154

2022

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Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis

Advances in biological regulation, 2017-01, Vol.63, p.140-155

2017

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Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

Biochemical journal, 2009-11, Vol.424 (2), p.273-283

2009

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Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

PloS one, 2017-09, Vol.12 (9), p.e0184818

2017

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Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics

Biochimica et biophysica acta, 2014-05, Vol.1841 (5), p.727-737

2014

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Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases

PloS one, 2022-09, Vol.17 (9), p.e0271540-e0271540

2022

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Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase

Structure (London), 2015-08, Vol.23 (8), p.1482-1491

2015

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Functions of neutral ceramidase in the Golgi apparatus

Journal of lipid research, 2018-11, Vol.59 (11), p.2116-2125

2018

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Role of sphingolipids in senescence: implication in aging and age-related diseases

The Journal of clinical investigation, 2018-07, Vol.128 (7), p.2702-2712

2018

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Intracellular sphingosine kinase 2‐derived sphingosine‐1‐phosphate mediates epidermal growth factor‐induced ezrin‐radixin‐moesin phosphorylation and cancer cell invasion

The FASEB journal, 2015-11, Vol.29 (11), p.4654-4669

2015

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Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis[S]

Journal of lipid research, 2019-04, Vol.60 (4), p.819-831

2019

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Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer

PloS one, 2021-05, Vol.16 (5), p.e0252311-e0252311

2021

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Ceramide synthases at the centre of sphingolipid metabolism and biology

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

Advances in determining signaling mechanisms of ceramide and role in disease

Ceramide and apoptosis: exploring the enigmatic connections between sphingolipid metabolism and programmed cell death

Sphingolipids and their metabolism in physiology and disease

Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors

Evolving concepts in cancer therapy through targeting sphingolipid metabolism

The Ceramide-centric Universe of Lipid-mediated Cell Regulation: Stress Encounters of the Lipid Kind

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation

Murine Model for Colitis-Associated Cancer of the Colon

A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation

Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells

GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis

1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase

Sphingolipids in neutrophil function and inflammatory responses: Mechanisms and implications for intestinal immunity and inflammation in ulcerative colitis

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation

Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics

Alkaline ceramidase catalyzes the hydrolysis of ceramides via a catalytic mechanism shared by Zn2+-dependent amidases

Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase

Functions of neutral ceramidase in the Golgi apparatus

Role of sphingolipids in senescence: implication in aging and age-related diseases

Intracellular sphingosine kinase 2‐derived sphingosine‐1‐phosphate mediates epidermal growth factor‐induced ezrin‐radixin‐moesin phosphorylation and cancer cell invasion

Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis[S]

Loss of sphingosine kinase 1 increases lung metastases in the MMTV-PyMT mouse model of breast cancer

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