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Discovery of New Orally Active Phosphodiesterase (PDE4) Inhibitors

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(9), pp.1098-1104

2004

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Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors

Bioorganic & medicinal chemistry, 2004-10, Vol.12 (19), p.5063-5078

2004

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New orally active PDE4 inhibitors with therapeutic potential

Bioorganic & medicinal chemistry, 2004-08, Vol.12 (15), p.4089-4100

2004

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Effect of a peptide leukotriene antagonist, ONO-1078 on antigen-induced airway microvascular leakage in actively sensitized guinea pigs

Life sciences (1973), 1992, Vol.51 (20), p.1577-1583

1992

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Inhibitory effect of a peptide leukotriene antagonist ONO-1078 on LTD4- and antigen-induced thromboxane B2 production in guinea pig lungs

Life sciences (1973), 1993, Vol.52 (12), p.PL97-PL102

1993

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Orally active PDE4 inhibitors with therapeutic potential

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1323-1327

2004

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Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury

American journal of respiratory and critical care medicine, 1996-01, Vol.153 (1), p.391

1996

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Orally active PDE4 inhibitor with therapeutic potential

European journal of medicinal chemistry, 2004-07, Vol.39 (7), p.555-571

2004

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Highly potent PDE4 inhibitors with therapeutic potential

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.207-210

2004

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Highly potent PDE4 inhibitors with therapeutic potential

Bioorganic & medicinal chemistry, 2004-09, Vol.12 (17), p.4645-4665

2004

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Up-regulation of lymphocytic cholinergic activity by ONO-4819, a selective prostaglandin EP4 receptor agonist, in MOLT-3 human leukemic T cells

Vascular pharmacology, 2004-03, Vol.41 (2), p.51-58

2004

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Highly potent inhibitors of tnf- α production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Bioorganic & medicinal chemistry, 2002-12, Vol.10 (12), p.3787-3805

2002

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The effect of benzodiazepines and β-carbolines on gabastimulated chloride influx by membrane vesicles from the rat cerebral cortex

Biochemical and biophysical research communications, 1986-11, Vol.141 (1), p.1-6

1986

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Highly potent inhibitors of TNF-α production. Part 1: Discovery of chemical leads

Bioorganic & medicinal chemistry letters, 2002-03, Vol.12 (6), p.903-905

2002

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Up-regulation of lymphocytic cholinergic activity by ONO-4819, a selective prostaglandin EP 4 receptor agonist, in MOLT-3 human leukemic T cells

Vascular pharmacology, 2004, Vol.41 (2), p.51-58

2004

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Discovery of Novel Phosphonic Acid Derivatives as New Chemical Leads for Inhibitors of TNF-α production

Bioorganic & medicinal chemistry, 2002-12, Vol.10 (12), p.3807-3815

2002

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Highly potent inhibitors of TNF-α production. Part 2: Identification of drug candidates

Bioorganic & medicinal chemistry letters, 2002-03, Vol.12 (6), p.907-910

2002

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Highly potent inhibitors of TNF-α production. Part I: Discovery of new chemical leads and Their structure–Activity relationships

Bioorganic & medicinal chemistry, 2002-12, Vol.10 (12), p.3757-3786

2002

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New orally active PDE4 inhibitors with therapeutic potential

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.29-32

2004

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Synthesis, further biological evaluation and pharmacodynamics of newly discovered inhibitors of TNF-α production

Bioorganic & medicinal chemistry, 2003-09, Vol.11 (18), p.3937-3943

2003

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In Vivo Pharmacologic Profile of ONO-1078: A Potent, Selective and Orally Active Peptide Leukotriene (LT) Antagonist

The Japanese Journal of Pharmacology, 1992, Vol.60(3), pp.217-225

1992

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In Vitro Antagonism of ONO-1078, a Newly Developed Anti-Asthma Agent, against Peptide Leukotrienes in Isolated Guinea Pig Tissues

The Japanese Journal of Pharmacology, 1992, Vol.60(3), pp.227-237

1992

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Highly potent inhibitors of TNF-α production. Part I

Bioorganic & medicinal chemistry, 2002-12, Vol.10 (12), p.3757-3786

2002

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Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma

European journal of pharmacology, 1993-04, Vol.235 (2), p.211-219

1993

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ロイコトリエン受容体拮抗剤オノンの研究開発(20世紀を代表する創薬)(<特集>21世紀:薬学の時代へ)

ファルマシア, 2001/01/01, Vol.37(1), pp.16

小畠, 隆明

2001

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Discovery of New Orally Active Phosphodiesterase (PDE4) Inhibitors

Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors

New orally active PDE4 inhibitors with therapeutic potential

Effect of a peptide leukotriene antagonist, ONO-1078 on antigen-induced airway microvascular leakage in actively sensitized guinea pigs

Inhibitory effect of a peptide leukotriene antagonist ONO-1078 on LTD4- and antigen-induced thromboxane B2 production in guinea pig lungs

Orally active PDE4 inhibitors with therapeutic potential

Effect of a specific neutrophil elastase inhibitor, ONO-5046, on endotoxin-induced acute lung injury

Orally active PDE4 inhibitor with therapeutic potential

Highly potent PDE4 inhibitors with therapeutic potential

Highly potent PDE4 inhibitors with therapeutic potential

Up-regulation of lymphocytic cholinergic activity by ONO-4819, a selective prostaglandin EP4 receptor agonist, in MOLT-3 human leukemic T cells

Highly potent inhibitors of tnf- α production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

The effect of benzodiazepines and β-carbolines on gabastimulated chloride influx by membrane vesicles from the rat cerebral cortex

Highly potent inhibitors of TNF-α production. Part 1: Discovery of chemical leads

Up-regulation of lymphocytic cholinergic activity by ONO-4819, a selective prostaglandin EP 4 receptor agonist, in MOLT-3 human leukemic T cells

Discovery of Novel Phosphonic Acid Derivatives as New Chemical Leads for Inhibitors of TNF-α production

Highly potent inhibitors of TNF-α production. Part 2: Identification of drug candidates

Highly potent inhibitors of TNF-α production. Part I: Discovery of new chemical leads and Their structure–Activity relationships

New orally active PDE4 inhibitors with therapeutic potential

Synthesis, further biological evaluation and pharmacodynamics of newly discovered inhibitors of TNF-α production

In Vivo Pharmacologic Profile of ONO-1078: A Potent, Selective and Orally Active Peptide Leukotriene (LT) Antagonist

In Vitro Antagonism of ONO-1078, a Newly Developed Anti-Asthma Agent, against Peptide Leukotrienes in Isolated Guinea Pig Tissues

Highly potent inhibitors of TNF-α production. Part I

Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma

ロイコトリエン受容体拮抗剤オノンの研究開発(20世紀を代表する創薬)(<特集>21世紀:薬学の時代へ)

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