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A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.998-1002

2007

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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.923-928

2008

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The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (18), p.4397

2014

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Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models

ACS medicinal chemistry letters, 2016-03, Vol.7 (3), p.277-282

2016

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Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits

BMC musculoskeletal disorders, 2013-12, Vol.14 (1), p.344-344, Article 344

2013

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Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.980-984

2012

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Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Bioorganic & medicinal chemistry letters, 2011-12, Vol.21 (24), p.7281-7286

2011

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Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (1), p.623-627

2012

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Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L

Journal of medicinal chemistry, 2001-01, Vol.44 (1), p.94-104

2001

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Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1

Angewandte Chemie (International ed.), 2001-11, Vol.40 (21), p.4055-4060

2001

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Concise Total Syntheses of the Sesquiterpenoids (−)-Homalomenol A and (−)-Homalomenol B

Journal of organic chemistry, 1996-11, Vol.61 (24), p.8439-8447

1996

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Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6410-6420

2008

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The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.887-892

2010

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Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.675-679

2009

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The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment

Organic & biomolecular chemistry, 2005-07, Vol.3 (13), p.2399-2409

2005

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Studies in marine macrolide synthesis: Stereocontrolled synthesis of the AB-spiroacetal subunit of spongistatin 1 (altohyrtin A)

Tetrahedron letters, 1996-11, Vol.37 (47), p.8581-8584

1996

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β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.1066-1079

2006

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β-Substituted cyclohexanecarboxamide cathepsin K inhibitors: Modification of the 1,2-disubstituted aromatic core

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (11), p.3146-3151

2007

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The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Nav1.7

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (18), p.4397-4401

2014

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Iterative annulations leading to functionalized tricyclo-[6.4.0.0 1,5]dodecanes and tricyclo[5.3.2.0 4,11]dodecanes

Tetrahedron letters, 1995, Vol.36 (33), p.5857-5860

1995

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The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na v 1.7

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (18), p.4397-4401

2014

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Studies in marine macrolide synthesis: Synthesis of the C1C15 subunit of spongistatin 1 (altohyrtin A) and 15,16-anti aldol coupling reactions

Tetrahedron letters, 1997-11, Vol.38 (47), p.8241-8244

1997

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Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1 Financial support was provided by the EPSRC (GR/L41646), Cambridge Commonwealth Trust (Scholarship to M.J.C.), EC (Marie Curie Postdoctoral Fellowship to J.L.A.), DFG (Postdoctoral Fellowship to T.T.), NSERC-Canada (Postdoctoral Fellowship to R.M.O.), Churchill College (Research Fellowship to D.J.W.), Kingapos;s College and Sims Fund, Cambridge (Scholarship to D.Y.K.C.). We also thank Merck and AstraZeneca Pharmaceuticals for ge

Angewandte Chemie International Edition, 2001-11, Vol.40 (21), p.4055-4060

2001

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Remote, 1,5- anti stereoinduction in the boron-mediated aldol reactions of β-oxygenated methyl ketones

Tetrahedron letters, 1996-11, Vol.37 (47), p.8585-8588

1996

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Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia

A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na(v)1.7

Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models

Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits

Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series

Nicotinic acids: Liver-targeted SCD inhibitors with preclinical anti-diabetic efficacy

Discovery of potent and liver-selective stearoyl-CoA desaturase (SCD) inhibitors in an acyclic linker series

Novel, Nonpeptidic Cyanamides as Potent and Reversible Inhibitors of Human Cathepsins K and L

Stereocontrolled Total Synthesis of (+)-Altohyrtin A/Spongistatin 1

Concise Total Syntheses of the Sesquiterpenoids (−)-Homalomenol A and (−)-Homalomenol B

Identification of a Nonbasic, Nitrile-Containing Cathepsin K Inhibitor (MK-1256) that is Efficacious in a Monkey Model of Osteoporosis

The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor

Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment

Studies in marine macrolide synthesis: Stereocontrolled synthesis of the AB-spiroacetal subunit of spongistatin 1 (altohyrtin A)

β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K

β-Substituted cyclohexanecarboxamide cathepsin K inhibitors: Modification of the 1,2-disubstituted aromatic core

The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Nav1.7

Iterative annulations leading to functionalized tricyclo-[6.4.0.0 1,5]dodecanes and tricyclo[5.3.2.0 4,11]dodecanes

The discovery of benzenesulfonamide-based potent and selective inhibitors of voltage-gated sodium channel Na v 1.7

Studies in marine macrolide synthesis: Synthesis of the C1C15 subunit of spongistatin 1 (altohyrtin A) and 15,16-anti aldol coupling reactions

Remote, 1,5- anti stereoinduction in the boron-mediated aldol reactions of β-oxygenated methyl ketones

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