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Validated assays for human cytochrome P450 activities

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.647

2004

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Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression

The Journal of pharmacology and experimental therapeutics, 2000-07, Vol.294 (1), p.88

Obach, R S

2000

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The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

Drug metabolism and disposition, 2003-07, Vol.31 (7), p.815

2003

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Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing

Drug metabolism and disposition, 2005-10, Vol.33 (10), p.1409

2005

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Examination of 209 Drugs for Inhibition of Cytochrome P450 2C8

Journal of clinical pharmacology, 2005-01, Vol.45 (1), p.68-78

2005

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The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

The Journal of pharmacology and experimental therapeutics, 1997-10, Vol.283 (1), p.46

1997

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Drug metabolism and drug interactions: application and clinical value of in vitro models

Current drug metabolism, 2003-10, Vol.4 (5), p.423

2003

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Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes

Drug metabolism and disposition, 1999-11, Vol.27 (11), p.1350

Obach, R S

1999

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Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes

Drug metabolism and disposition, 2010-09, Vol.38 (9), p.1605

2010

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Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study

Clinical pharmacology and therapeutics, 2008-04, Vol.83 (4), p.567-576

2008

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Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

Chemical research in toxicology, 2009-02, Vol.22 (2), p.267-279

2009

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The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

The Journal of pharmacology and experimental therapeutics, 2006-01, Vol.316 (1), p.336

2006

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Physicochemical Determinants of Human Renal Clearance

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4844-4852

2009

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Reaction phenotyping in drug discovery: moving forward with confidence?

Current drug metabolism, 2003-12, Vol.4 (6), p.527

2003

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A comprehensive listing of bioactivation pathways of organic functional groups

Current drug metabolism, 2005-06, Vol.6 (3), p.161

2005

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Potent inhibition of human liver aldehyde oxidase by raloxifene

Drug metabolism and disposition, 2004-01, Vol.32 (1), p.89

Obach, R Scott

2004

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Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

Chemical research in toxicology, 2008-09, Vol.21 (9), p.1814-1822

2008

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In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude

Drug metabolism and disposition, 2005-06, Vol.33 (6), p.845

2005

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Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance

Journal of clinical pharmacology, 2013-02, Vol.53 (2), p.178-191

2013

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Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

Drug metabolism and disposition, 2019-09, Vol.47 (9), p.995-1003

2019

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Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study

Drug metabolism and disposition, 2005-02, Vol.33 (2), p.262

2005

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What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs

Drug metabolism reviews, 2007, Vol.39 (1), p.17-43

2007

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Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation

Current drug metabolism, 2007-06, Vol.8 (5), p.449

2007

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In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

Clinical pharmacology and therapeutics, 2005-12, Vol.78 (6), p.582-592

2005

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Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

Chemical research in toxicology, 2002-03, Vol.15 (3), p.269-299

2002

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Validated assays for human cytochrome P450 activities

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing

Examination of 209 Drugs for Inhibition of Cytochrome P450 2C8

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

Drug metabolism and drug interactions: application and clinical value of in vitro models

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes

Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes

Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study

Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

Physicochemical Determinants of Human Renal Clearance

Reaction phenotyping in drug discovery: moving forward with confidence?

A comprehensive listing of bioactivation pathways of organic functional groups

Potent inhibition of human liver aldehyde oxidase by raloxifene

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

In vitro-in vivo extrapolation of CYP2D6 inactivation by paroxetine: prediction of nonstationary pharmacokinetics and drug interaction magnitude

Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study

What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs

Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation

In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings

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