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Validated assays for human cytochrome P450 activities

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.647-660

2004

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Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy

Pharmacological reviews, 2013-04, Vol.65 (2), p.578-640

2013

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Linezolid Metabolism Is Catalyzed by Cytochrome P450 2J2, 4F2, and 1B1

Drug metabolism and disposition, 2022-04, Vol.50 (4), p.413-421

Obach, R Scott

2022

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Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds

Drug metabolism and disposition, 2018-11, Vol.46 (11), p.1466-1477

2018

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Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans

Drug metabolism and disposition, 2022-05, Vol.50 (5), p.576-590

2022

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Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes

Drug metabolism and disposition, 1999-11, Vol.27 (11), p.1350

Obach, R S

1999

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Addressing the Challenges of Low Clearance in Drug Research

The AAPS journal, 2015-03, Vol.17 (2), p.352-357

2015

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Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes

Drug metabolism and disposition, 2010-09, Vol.38 (9), p.1605-1611

2010

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Predicting clearance in humans from in vitro data

Current topics in medicinal chemistry, 2011-02, Vol.11 (4), p.334-339

Obach, R Scott

2011

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Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants

Drug metabolism and disposition, 2021-06, Vol.49 (6), p.442-450

2021

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Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8441-8460

2010

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The Drug-Drug Interaction between Erlotinib and OSI-930 Is Mediated through Aldehyde Oxidase Inhibition

Drug metabolism and disposition, 2024-09, Vol.52 (9), p.1020-1028

2024

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Emerging Models of Drug Metabolism, Transporters, and Toxicity

Drug metabolism and disposition, 2018-11, Vol.46 (11), p.1556-1561

2018

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Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds

Drug metabolism and disposition, 2008-07, Vol.36 (7), p.1385-1405

2008

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Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes

Drug metabolism and disposition, 2024-05, Vol.52 (6), p.565-573

2024

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A comprehensive listing of bioactivation pathways of organic functional groups

Current drug metabolism, 2005-06, Vol.6 (3), p.161-225

2005

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Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions

Drug metabolism and disposition, 2007-02, Vol.35 (2), p.246-255

2007

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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Nature communications, 2021-10, Vol.12 (1), p.6055-17, Article 6055

2021

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Managing the challenge of chemically reactive metabolites in drug development

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.292-306

2011

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Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression

The Journal of pharmacology and experimental therapeutics, 2000-07, Vol.294 (1), p.88

Obach, R S

2000

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Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

Journal of medicinal chemistry, 2014-12, Vol.57 (23), p.10072-10079

2014

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Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping

Drug metabolism and disposition, 2022-03, Vol.50 (3), p.249-257

2022

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Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition

Drug metabolism and disposition, 2021-09, Vol.49 (9), p.822-832

2021

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Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data

Drug metabolism and disposition, 2016-05, Vol.44 (5), p.781-791

2016

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The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration

Drug metabolism and disposition, 2023-10, Vol.51 (10), p.1419-1427

2023

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Validated assays for human cytochrome P450 activities

Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy

Linezolid Metabolism Is Catalyzed by Cytochrome P450 2J2, 4F2, and 1B1

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds

Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes

Addressing the Challenges of Low Clearance in Drug Research

Cytochrome P450 3A4 mRNA is a more reliable marker than CYP3A4 activity for detecting pregnane X receptor-activated induction of drug-metabolizing enzymes

Predicting clearance in humans from in vitro data

Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

The Drug-Drug Interaction between Erlotinib and OSI-930 Is Mediated through Aldehyde Oxidase Inhibition

Emerging Models of Drug Metabolism, Transporters, and Toxicity

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds

Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes

A comprehensive listing of bioactivation pathways of organic functional groups

Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Managing the challenge of chemically reactive metabolites in drug development

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression

Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors

Intersystem Extrapolation Factors Are Substrate-Dependent for CYP3A4: Impact on Cytochrome P450 Reaction Phenotyping

Development of Robust Quantitative Structure-Activity Relationship Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition

Mechanistic Modeling to Predict Midazolam Metabolite Exposure from In Vitro Data

The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration

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