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Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

ACS medicinal chemistry letters, 2014-04, Vol.5 (4), p.309-314

2014

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The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6223-6227

2013

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Abstract 2789: Discovery of a novel specific MEK and Raf inhibitor, CH5126766 (RO5126766), hit to lead study of a unique scaffold for kinase inhibitor to a clinical compound

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.2789-2789

2011

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water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts

Cancer chemotherapy and pharmacology, 2010, Vol.65 (2), p.363-371

2010

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Synthesis of new camptothecin analogs with improved antitumor activities

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.2018-2021

2009

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Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (10), p.2772-2776

2009

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A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts

Cancer chemotherapy and pharmacology, 2010, Vol.65 (5), p.363-371

2010

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Design and synthesis of 10-oxo derivative of N-cyclopropylmethyl (−)-6β-acetylthiodihydro-normorphine, a potentially κ-selective opioid receptor ligand

Bioorganic & medicinal chemistry letters, 1995-07, Vol.5 (14), p.1505-1508

1995

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Trial in progress: A phase I trial of dual EZH 1/2 inhibitor valemetostat tosylate (DS-3201b) in pediatric, adolescent, and young adult patients with malignant solid tumors

Journal of clinical oncology, 2022-06, Vol.40 (16_suppl), p.TPS10059-TPS10059

2022

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P5-6 Clinical feasibility and current trends of approved multigene panels in a genomic medicine cooperative hospital

Annals of oncology, 2022-07, Vol.33, p.S513

2022

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Study on prevention of hypercapnia by nasal high flow in patients undergoing endoscopic retrograde cholangiopancreatography during intravenous anesthesia

Medicine (Baltimore), 2020-05, Vol.99 (19), p.e20036-e20036

2020

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P33-1 Clinical feasibility of approved multigene panels in a Japanese local cancer accredited hospital

Annals of oncology, 2021-07, Vol.32, p.S350-S350

2021

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MO3-6-4The first step of precision medicine with blood based genomic sequencing assay in a Japanese local university hospital

Annals of oncology, 2019-10, Vol.30 (Supplement_6)

2019

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The first step of precision medicine with blood based genomic sequencing assay in a Japanese local university hospital

Annals of oncology, 2019-10, Vol.30, p.vi112

2019

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Clinical features of women with thrombotic microangiopathy in pregnancy: A case series from a single Japanese tertiary perinatal care center

The journal of obstetrics and gynaecology research, 2023-12, Vol.49 (12), p.2804-2810

2023

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Regional Peak Longitudinal-Strain by 2D Speckle-Tracking TTE Provides Useful Information to Distinguish Fibrotic from Non-Fibrotic Lesions in LV Myocardium on Cardiac MR in Hypertrophic Cardiomyopathy

International journal of cardiology, 2013-10, Vol.168 (4), p.4520-4523

2013

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Risk stratification using myocardial peak longitudinal-strain on speckle-tracking transthoracic-echocardiogram to predict major adverse cardiac events in non ischemic hypertrophic-cardiomyopathy subjects confirmed by MDCT

International journal of cardiology, 2013-10, Vol.168 (4), p.4586-4589

2013

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Distinguishing 320 slice CT-detected focal fibrotic lesions and non-fibrotic lesions in hypertrophic cardiomyopathy by assessment of regional myocardial strain using two dimensional speckle tracking echocardiography

International journal of cardiology, 2013-11, Vol.169 (6), p.e109-e113

2013

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A STUDY ON THREE-DIMENSIONAL MODEL FOR SLUICE GATE PROJECT

Journal of Japan Society of Civil Engineers, Ser. F3 (Civil Engineering Informatics), 2018, Vol.74 (2), p.II_32-II_40

2018

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A Case of Composite Lymphoma with Extranodal NK/T-cell Lymphoma, Nasal-type and Diffuse Large B-cell Lymphoma

Journal of Clinical and Experimental Hematopathology, 2019-04, Vol.59 (1), p.34-39

2019

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Efficiency of quantitative longitudinal peak systolic strain values using automated function imaging on transthoracic echocardiogram for evaluating left ventricular wall motion: New diagnostic criteria and agreement with naked eye evaluation by experienced cardiologist

International journal of cardiology, 2013-08, Vol.167 (4), p.1625-1631

2013

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LPS induces stefin A3 expression in mouse primary cultured glial cells

Brain research. Molecular brain research., 2005-10, Vol.140 (1), p.138-141

2005

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Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning

The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors

Abstract 2789: Discovery of a novel specific MEK and Raf inhibitor, CH5126766 (RO5126766), hit to lead study of a unique scaffold for kinase inhibitor to a clinical compound

water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts

Synthesis of new camptothecin analogs with improved antitumor activities

Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog

A water soluble prodrug of a novel camptothecin analog is efficacious against breast cancer resistance protein-expressing tumor xenografts

Design and synthesis of 10-oxo derivative of N-cyclopropylmethyl (−)-6β-acetylthiodihydro-normorphine, a potentially κ-selective opioid receptor ligand

Trial in progress: A phase I trial of dual EZH 1/2 inhibitor valemetostat tosylate (DS-3201b) in pediatric, adolescent, and young adult patients with malignant solid tumors

P5-6 Clinical feasibility and current trends of approved multigene panels in a genomic medicine cooperative hospital

Study on prevention of hypercapnia by nasal high flow in patients undergoing endoscopic retrograde cholangiopancreatography during intravenous anesthesia

P33-1 Clinical feasibility of approved multigene panels in a Japanese local cancer accredited hospital

MO3-6-4The first step of precision medicine with blood based genomic sequencing assay in a Japanese local university hospital

The first step of precision medicine with blood based genomic sequencing assay in a Japanese local university hospital

Clinical features of women with thrombotic microangiopathy in pregnancy: A case series from a single Japanese tertiary perinatal care center

Regional Peak Longitudinal-Strain by 2D Speckle-Tracking TTE Provides Useful Information to Distinguish Fibrotic from Non-Fibrotic Lesions in LV Myocardium on Cardiac MR in Hypertrophic Cardiomyopathy

Risk stratification using myocardial peak longitudinal-strain on speckle-tracking transthoracic-echocardiogram to predict major adverse cardiac events in non ischemic hypertrophic-cardiomyopathy subjects confirmed by MDCT

Distinguishing 320 slice CT-detected focal fibrotic lesions and non-fibrotic lesions in hypertrophic cardiomyopathy by assessment of regional myocardial strain using two dimensional speckle tracking echocardiography

A STUDY ON THREE-DIMENSIONAL MODEL FOR SLUICE GATE PROJECT

A Case of Composite Lymphoma with Extranodal NK/T-cell Lymphoma, Nasal-type and Diffuse Large B-cell Lymphoma

Efficiency of quantitative longitudinal peak systolic strain values using automated function imaging on transthoracic echocardiogram for evaluating left ventricular wall motion: New diagnostic criteria and agreement with naked eye evaluation by experienced cardiologist

LPS induces stefin A3 expression in mouse primary cultured glial cells

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