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Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer

Journal for immunotherapy of cancer, 2020-05, Vol.8 (1), p.e000564

2020

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Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGFβ and PD-L1, in Patients with Esophageal Squamous Cell Carcinoma: Results from a Phase 1 Cohort in Asia

Targeted oncology, 2021-07, Vol.16 (4), p.447-459

2021

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Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma

Cancer cell, 2002-12, Vol.2 (6), p.485-495

2002

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The role of PGP9.5 as a tumor suppressor gene in human cancer

International journal of cancer, 2008-08, Vol.123 (4), p.753-759

2008

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Cloning and functional analysis of human p51 , which structurally and functionally resembles p53

Nature medicine, 1998-07, Vol.4 (7), p.839-843

1998

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N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer

Cancer research (Chicago, Ill.), 2006-04, Vol.66 (7), p.3409-3418

2006

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PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma

Cancer research (Chicago, Ill.), 2005-06, Vol.65 (11), p.4963-4968

2005

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Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing

Cancer research (Chicago, Ill.), 2004-09, Vol.64 (17), p.5982-5987

2004

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p63 Transcriptional Regulation of Epithelial Integrity and Cancer

Cell cycle (Georgetown, Tex.), 2007-02, Vol.6 (3), p.240-245

2007

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RACK1 and Stratifin Target ΔNp63α for a Proteasome Degradation in Head and Neck Squamous Cell Carcinoma Cells upon DNA Damage

Cell cycle (Georgetown, Tex.), 2004-10, Vol.3 (10), p.1285-1295

2004

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PGP9.5 methylation in diffuse-type gastric cancer

Cancer research (Chicago, Ill.), 2006-04, Vol.66 (7), p.3921-3927

2006

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HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma

Molecular cancer research, 2008-01, Vol.6 (1), p.31-41

2008

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effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity

The FASEB journal, 2006-01, Vol.20 (1), p.112-114

2006

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p51/p63 Controls Subunit α3 of the Major Epidermis Integrin Anchoring the Stem Cells to the Niche

The Journal of biological chemistry, 2004-11, Vol.279 (48), p.50069-50077

2004

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DCC promoter hypermethylation in esophageal squamous cell carcinoma

International journal of cancer, 2008-06, Vol.122 (11), p.2498-2502

2008

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p63-Specific Activation of the BPAG-1e Promoter

Journal of investigative dermatology, 2005-07, Vol.125 (1), p.52-60

2005

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A Promoter Methylation Pattern in the N-Methyl-d-Aspartate Receptor 2B Gene Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma

Clinical cancer research, 2007-11, Vol.13 (22), p.6658-6665

2007

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Safety and Tolerability of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGFβ and PD-L1, in Asian Patients with Pretreated Recurrent or Refractory Gastric Cancer

Clinical cancer research, 2020-07, Vol.26 (13), p.3202-3210

2020

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Altered Sumoylation of p63α Contributes to the Split-Hand/Foot Malformation Phenotype

Cell cycle (Georgetown, Tex.), 2004-12, Vol.3 (12), p.1587-1596

2004

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Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1

Cancer chemotherapy and pharmacology, 2022-10, Vol.90 (4), p.369-379

2022

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A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors

Cancer chemotherapy and pharmacology, 2017-01, Vol.79 (1), p.89-98

2017

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Bintrafusp alfa and chemotherapy as first-line treatment in biliary tract cancer: A randomized phase 2/3 trial

Hepatology (Baltimore, Md.), 2024-06

2024

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First-in-Human Phase I Study of Aprutumab Ixadotin, a Fibroblast Growth Factor Receptor 2 Antibody–Drug Conjugate (BAY 1187982) in Patients with Advanced Cancer

Targeted oncology, 2019-10, Vol.14 (5), p.591-601

2019

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P5-5 Phase 2/3 study of bintrafusp alfa with gemcitabine plus cisplatin as first-line treatment of biliary tract cancer

Annals of oncology, 2021-07, Vol.32, p.S333-S333

2021

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The Ah Receptor Is Not Involved in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated Apoptosis in Human Leukemic T Cell Lines

The Journal of biological chemistry, 1998-07, Vol.273 (31), p.19853-19858

1998

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Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer

Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGFβ and PD-L1, in Patients with Esophageal Squamous Cell Carcinoma: Results from a Phase 1 Cohort in Asia

Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma

The role of PGP9.5 as a tumor suppressor gene in human cancer

Cloning and functional analysis of human p51 , which structurally and functionally resembles p53

N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer

PGP9.5 promoter methylation is an independent prognostic factor for esophageal squamous cell carcinoma

Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing

p63 Transcriptional Regulation of Epithelial Integrity and Cancer

RACK1 and Stratifin Target ΔNp63α for a Proteasome Degradation in Head and Neck Squamous Cell Carcinoma Cells upon DNA Damage

PGP9.5 methylation in diffuse-type gastric cancer

HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma

effect of p53-RNAi and p53 knockout on human 8-oxoguanine DNA glycosylase (hOgg1) activity

p51/p63 Controls Subunit α3 of the Major Epidermis Integrin Anchoring the Stem Cells to the Niche

DCC promoter hypermethylation in esophageal squamous cell carcinoma

p63-Specific Activation of the BPAG-1e Promoter

A Promoter Methylation Pattern in the N-Methyl-d-Aspartate Receptor 2B Gene Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma

Safety and Tolerability of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGFβ and PD-L1, in Asian Patients with Pretreated Recurrent or Refractory Gastric Cancer

Altered Sumoylation of p63α Contributes to the Split-Hand/Foot Malformation Phenotype

Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1

A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors

Bintrafusp alfa and chemotherapy as first-line treatment in biliary tract cancer: A randomized phase 2/3 trial

First-in-Human Phase I Study of Aprutumab Ixadotin, a Fibroblast Growth Factor Receptor 2 Antibody–Drug Conjugate (BAY 1187982) in Patients with Advanced Cancer

P5-5 Phase 2/3 study of bintrafusp alfa with gemcitabine plus cisplatin as first-line treatment of biliary tract cancer

The Ah Receptor Is Not Involved in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated Apoptosis in Human Leukemic T Cell Lines

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