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Clinical Trial of the Pan‐Caspase Inhibitor, IDN‐6556, in Human Liver Preservation Injury

American journal of transplantation, 2007-01, Vol.7 (1), p.218-225

2007

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Abrogation of Disease Development in Plants Expressing Animal Antiapoptotic Genes

Proceedings of the National Academy of Sciences - PNAS, 2001-06, Vol.98 (12), p.6957-6962

2001

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Cloning and Characterization of a Functionally Distinct Corticotropin- Releasing Factor Receptor Subtype from Rat Brain

Proceedings of the National Academy of Sciences - PNAS, 1995-01, Vol.92 (3), p.836-840

1995

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β -amyloid Precursor Protein of Alzheimer Disease Occurs as 110- to 135-Kilodalton Membrane-Associated Proteins in Neural and Nonneural Tissues

Proceedings of the National Academy of Sciences - PNAS, 1988-10, Vol.85 (19), p.7341-7345

1988

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Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

Molecular and Cellular Biology, 2005-03, Vol.25 (5), p.1869-1878

2005

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The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

The Journal of biological chemistry, 1990-03, Vol.265 (8), p.4492-4497

1990

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The β -amyloid Protein Precursor of Alzheimer Disease has Soluble Derivatives Found in Human Brain and Cerebrospinal Fluid

Proceedings of the National Academy of Sciences - PNAS, 1989-08, Vol.86 (16), p.6338-6342

1989

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Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

Journal of medicinal chemistry, 2004-08, Vol.47 (18), p.4417-4426

2004

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IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95), bax, caspases, and anticancer drugs

Cancer research (Chicago, Ill.), 1998-12, Vol.58 (23), p.5315-5320

1998

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Solution Structure of the Antiapoptotic Protein bcl-2

Proceedings of the National Academy of Sciences - PNAS, 2001-03, Vol.98 (6), p.3012-3017

2001

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Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

Molecular cancer therapeutics, 2005-06, Vol.4 (6), p.977-986

2005

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Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Journal of medicinal chemistry, 2006-02, Vol.49 (3), p.1165-1181

2006

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Regulated cleavage of alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail

Neuroscience, 1993-12, Vol.57 (4), p.873-877

1993

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Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Nature (London), 1992-12, Vol.360 (6405), p.672-674

1992

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Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers

Bioorganic & medicinal chemistry letters, 2006-07, Vol.16 (13), p.3424-3429

2006

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Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid

Endocrinology (Philadelphia), 1996-01, Vol.137 (1), p.72-77

1996

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Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.2000-2007

2006

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Isoquinoline–pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (12), p.3150-3155

2006

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Conversion of the Alzheimer's beta-amyloid precursor protein (APP) Kunitz domain into a potent human neutrophil elastase inhibitor

The Journal of biological chemistry, 1991-11, Vol.266 (31), p.21011-21013

1991

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Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid

Endocrinology (Philadelphia), 1996-01, Vol.137 (1), p.72-77

1996

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Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

Nature (London), 1993-01, Vol.361 (6409), p.260-263

1993

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Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (6), p.1679-1685

2006

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Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe

Molecular biology of the cell, 1997-02, Vol.8 (2), p.325-339

1997

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A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members

The Journal of biological chemistry, 1997-04, Vol.272 (17), p.11350-11355

1997

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Clinical Trial of the Pan‐Caspase Inhibitor, IDN‐6556, in Human Liver Preservation Injury

Abrogation of Disease Development in Plants Expressing Animal Antiapoptotic Genes

Cloning and Characterization of a Functionally Distinct Corticotropin- Releasing Factor Receptor Subtype from Rat Brain

β -amyloid Precursor Protein of Alzheimer Disease Occurs as 110- to 135-Kilodalton Membrane-Associated Proteins in Neural and Nonneural Tissues

Role for Akt3/Protein Kinase Bγ in Attainment of Normal Brain Size

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

The Alzheimer amyloid precursor protein. Identification of a stable intermediate in the biosynthetic/degradative pathway

The β -amyloid Protein Precursor of Alzheimer Disease has Soluble Derivatives Found in Human Brain and Cerebrospinal Fluid

Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer

IAP-family protein Survivin inhibits caspase activity and apoptosis induced by Fas (CD95), bax, caspases, and anticancer drugs

Solution Structure of the Antiapoptotic Protein bcl-2

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Regulated cleavage of alzheimer β-amyloid precursor protein in the absence of the cytoplasmic tail

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Discovery and SAR of oxindole–pyridine-based protein kinase B/Akt inhibitors for treating cancers

Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid

Synthesis and structure–activity relationship of 3,4′-bispyridinylethylenes: Discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer

Isoquinoline–pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity

Conversion of the Alzheimer's beta-amyloid precursor protein (APP) Kunitz domain into a potent human neutrophil elastase inhibitor

Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid

Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide

Discovery of trans-3,4′-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation

Bax- and Bak-induced cell death in the fission yeast Schizosaccharomyces pombe

A Common Binding Site Mediates Heterodimerization and Homodimerization of Bcl-2 Family Members

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