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Protein Biomarker Quantification by Immunoaffinity Liquid Chromatography-Tandem Mass Spectrometry: Current State and Future Vision

Clinical chemistry (Baltimore, Md.), 2020-02, Vol.66 (2), p.282-301

2020

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A peptide immunoaffinity LC–MS/MS strategy for quantifying the GPCR protein, S1PR1 in human colon biopsies

Bioanalysis, 2020-09, Vol.12 (18), p.1311-1324

2020

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Ultrahigh-Throughput and Chromatography-Free Bioanalysis of Polar Analytes with Acoustic Ejection Mass Spectrometry

Analytical chemistry (Washington), 2020-10, Vol.92 (19), p.13525-13531

2020

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LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy

Analytical biochemistry, 2020-08, Vol.602, p.113766-113766, Article 113766

2020

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Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2022-09, Vol.1207, p.123305-123305, Article 123305

2022

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Immunoaffinity enrichment LC–MS/MS quantitation of CDH17 in tissues

Bioanalysis, 2020-10, Vol.12 (20), p.1439-1447

2020

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Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen

Rapid communications in mass spectrometry, 2011-05, Vol.25 (9), p.1231-1240

2011

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An integrated Qual/Quan strategy for ganglioside lipidomics using high‐resolution mass spectrometry and Skyline software

Rapid communications in mass spectrometry, 2021-04, Vol.35 (7), p.e9041-n/a

2021

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A strategy for liquid chromatography/tandem mass spectrometry based quantitation of pegylated protein drugs in plasma using plasma protein precipitation with water-miscible organic solvents and subsequent trypsin digestion to generate surrogate peptides for detection

Rapid communications in mass spectrometry, 2011-01, Vol.25 (2), p.281-290

2011

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Analytical considerations for quantitative LC-MS strategies for measuring antibody drug-target engagement in tissues

Bioanalysis, 2017-12, Vol.9 (23), p.1845-1847

2017

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Immunoaffinity LC-MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker

Bioanalysis, 2017-10, Vol.9 (20), p.1573-1588

2017

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N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations

Journal of pharmaceutical sciences, 2008-07, Vol.97 (7), p.2568-2580

2008

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Quantification of surrogate monoclonal antibodies in mouse serum using LC–MS/MS

Bioanalysis, 2021-02, Vol.13 (3), p.147-164

2021

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The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds

Rapid communications in mass spectrometry, 1999-06, Vol.13 (12), p.1175-1185

1999

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LC-MS/MS multiplexed assay for the quantitation of a therapeutic protein BMS-986089 and the target protein Myostatin

Bioanalysis, 2016-02, Vol.8 (3), p.193-204

2016

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The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay

Analytical biochemistry, 2016-06, Vol.503, p.71-78

2016

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Increasing high-throughput Discovery bioanalysis using automated selected reaction monitoring compound optimization, ultra-high-pressure liquid chromatography, and single-step sample preparation workflows

Rapid communications in mass spectrometry, 2009-11, Vol.23 (21), p.3457-3464

2009

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Bioanalytical strategies for developing highly sensitive liquid chromatography/tandem mass spectrometry based methods for the peptide GLP-1 agonists in support of discovery PK/PD studies

Rapid communications in mass spectrometry, 2011-11, Vol.25 (22), p.3427-3435

2011

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Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays

Bioanalysis, 2016-07, Vol.8 (13), p.1383-1401

2016

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The integration of ligand binding and LC-MS-based assays into bioanalytical strategies for protein analysis

Bioanalysis, 2014-01, Vol.6 (13), p.1827-1841

2014

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Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum

Rapid communications in mass spectrometry, 2014-07, Vol.28 (13), p.1535-1543

2014

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Effect of mobile phase pH, aqueous-organic ratio, and buffer concentration on electrospray ionization tandem mass spectrometric fragmentation patterns: implications in liquid chromatography/tandem mass spectrometric bioanalysis

Rapid communications in mass spectrometry, 2010-11, Vol.24 (22), p.3221-3229

2010

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Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method

Bioanalysis, 2010-04, Vol.2 (4), p.745-753

2010

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Analysis of l-serine-O-phosphate in cerebrospinal spinal fluid by derivatization–liquid chromatography/mass spectrometry

Analytical biochemistry, 2014-05, Vol.452, p.10-12

2014

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Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS

Bioanalysis, 2016-08, Vol.8 (15), p.1611-1622

2016

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Protein Biomarker Quantification by Immunoaffinity Liquid Chromatography-Tandem Mass Spectrometry: Current State and Future Vision

A peptide immunoaffinity LC–MS/MS strategy for quantifying the GPCR protein, S1PR1 in human colon biopsies

Ultrahigh-Throughput and Chromatography-Free Bioanalysis of Polar Analytes with Acoustic Ejection Mass Spectrometry

LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy

Quantification of Linrodostat and its metabolites: Overcoming bioanalytical challenges in support of a discovery Indoleamine 2,3 dioxygenase program

Immunoaffinity enrichment LC–MS/MS quantitation of CDH17 in tissues

Ultrafast mass spectrometry based bioanalytical method for digoxin supporting an in vitro P-glycoprotein (P-gp) inhibition screen

An integrated Qual/Quan strategy for ganglioside lipidomics using high‐resolution mass spectrometry and Skyline software

A strategy for liquid chromatography/tandem mass spectrometry based quantitation of pegylated protein drugs in plasma using plasma protein precipitation with water-miscible organic solvents and subsequent trypsin digestion to generate surrogate peptides for detection

Analytical considerations for quantitative LC-MS strategies for measuring antibody drug-target engagement in tissues

Immunoaffinity LC-MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker

N-in-1 Dosing Pharmacokinetics in Drug Discovery: Experience, Theoretical and Practical Considerations

Quantification of surrogate monoclonal antibodies in mouse serum using LC–MS/MS

The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds

LC-MS/MS multiplexed assay for the quantitation of a therapeutic protein BMS-986089 and the target protein Myostatin

The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay

Increasing high-throughput Discovery bioanalysis using automated selected reaction monitoring compound optimization, ultra-high-pressure liquid chromatography, and single-step sample preparation workflows

Bioanalytical strategies for developing highly sensitive liquid chromatography/tandem mass spectrometry based methods for the peptide GLP-1 agonists in support of discovery PK/PD studies

Antibody-drug conjugate bioanalysis using LB-LC-MS/MS hybrid assays: strategies, methodology and correlation to ligand-binding assays

The integration of ligand binding and LC-MS-based assays into bioanalytical strategies for protein analysis

Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum

Effect of mobile phase pH, aqueous-organic ratio, and buffer concentration on electrospray ionization tandem mass spectrometric fragmentation patterns: implications in liquid chromatography/tandem mass spectrometric bioanalysis

Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method

Analysis of l-serine-O-phosphate in cerebrospinal spinal fluid by derivatization–liquid chromatography/mass spectrometry

Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS

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