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Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia

Psychopharmacology, 2015-08, Vol.232 (15), p.2849-2861

2015

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Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Bioorganic & medicinal chemistry, 2004-01, Vol.12 (2), p.423-438

2004

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Melanocortin-4 receptor antagonists for the treatment of depression and anxiety disorders

Current topics in medicinal chemistry, 2007-06, Vol.7 (11), p.1145-1151

2007

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Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor

The Journal of pharmacology and experimental therapeutics, 2003-02, Vol.304 (2), p.818-826

2003

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Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001

The Journal of pharmacology and experimental therapeutics, 1999-05, Vol.289 (2), p.926

1999

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Design, synthesis, and structure–activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands

Bioorganic & medicinal chemistry, 2004-07, Vol.12 (13), p.3569-3580

2004

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Structure–activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (5), p.1989-2005

2007

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Non-monoamine-based approach for the treatment of depression and anxiety disorders

Recent patents on CNS drug discovery, 2006-01, Vol.1 (1), p.1-27

2006

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Identification of Arginine Analogues as Antagonists and Agonists for the Melanocortin-4 Receptor

Chemical and Pharmaceutical Bulletin, 2007/08/01, Vol.55(8), pp.1232-1239

2007

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Binding characteristics of [formula omitted]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors

European journal of pharmacology, 1999-04, Vol.371 (2), p.197-204

1999

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Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106

Life sciences (1973), 1999-03, Vol.64 (16), p.1455-1464

1999

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Synthesis of Diphenylmethyl Analogues and Their Affinity for the Melanocortin-4 Receptor and the Serotonin Transporter

Chemical and Pharmaceutical Bulletin, 2007, Vol.55(7), pp.1044-1050

2007

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Identification of Arginine Analogues as Antagonists and Agonists for the Melanocortin-4 Receptor

Chemical & Pharmaceutical Bulletin, 2007, Vol.55 (8), p.1232-1239

2007

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Development of a Method for Evaluating Drug-Likeness and Ease of Synthesis Using a Data Set in Which Compounds Are Assigned Scores Based on Chemists' Intuition

Journal of Chemical Information and Computer Sciences, 2003-07, Vol.43 (4), p.1269-1275

2003

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Synthesis of Diphenylmethyl Analogues and Their Affinity for the Melanocortin-4 Receptor and the Serotonin Transporter

Chemical & Pharmaceutical Bulletin, 2007, Vol.55 (7), p.1044-1050

2007

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In vitro pharmacological profile of nonpeptide CRF1 receptor antagonists, CRA1000 and CRA1001

European journal of pharmacology, 1999-04, Vol.371 (2-3), p.205-211

1999

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Non-Monoamine-Based Approach for the Treatment of Depression and Anxiety Disorders

Recent patents on CNS drug discovery, 2012-07, Vol.1 (1), p.1-27

2012

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Novel piperazines: Potent melanocortin-4 receptor antagonists with anxiolytic-like activity

Bioorganic & medicinal chemistry, 2007-03, Vol.15 (6), p.2375-2385

2007

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MCL0042: A nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity

Pharmacology, biochemistry and behavior, 2005-12, Vol.82 (4), p.621-626

2005

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Methods for finding, evaluating and selecting researchers for collaboration to enter a new business : How to search for suitable researchers for academic-industrial collaboration(<Special feature>The 11th information professional symposium: INFOPRO2014)

The Journal of Information Science and Technology Association, 2015/03/01, Vol.65(3), pp.123-129

2015

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Chemical modification of aryl-1,2,3,6-tetrahydropyridinopyrimidine derivative to discover corticotropin-releasing factor1 receptor antagonists Aryl-1,2,3,6-tetrahydropyridino-purine, -3H-1,2,3-triazolo[4,5-d]pyrimidine, -purin-8-one, and -7H-pyrrolo[2,3-d]pyrimidine derivatives

Bioorganic & medicinal chemistry, 2001-05, Vol.9 (5), p.1357-1363

Kumagai, T

2001

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将来の新事業展開のために連携すべき研究者を発掘・評価・選定する手法(<特集>第11回情報プロフェッショナルシンポジウム)

情報の科学と技術, 2015/03/01, Vol.65(3), pp.123-129

2015

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Synthesis and structure–affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor1 receptor antagonists

Bioorganic & medicinal chemistry, 2001-05, Vol.9 (5), p.1349-1355

Kumagai, T

2001

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Design, synthesis and structure-affinity relationships of 4-methylidenepiperidine and 4-aryl-1,2,3,6-tetrahydropyridine derivatives as corticotropin-releasing factor1 receptor antagonists

Bioorganic & medicinal chemistry, 2000-05, Vol.8 (5), p.1183-1193

2000

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Synthesis and structure–affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor 1 receptor antagonists

Bioorganic & medicinal chemistry, 2001, Vol.9 (5), p.1349-1355

2001

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Efficacy of a glycine transporter 1 inhibitor TASP0315003 in animal models of cognitive dysfunction and negative symptoms of schizophrenia

Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands

Melanocortin-4 receptor antagonists for the treatment of depression and anxiety disorders

Anxiolytic-like and antidepressant-like activities of MCL0129 (1-[(S)-2-(4-fluorophenyl)-2-(4-isopropylpiperadin-1-yl)ethyl]-4-[4-(2-methoxynaphthalen-1-yl)butyl]piperazine), a novel and potent nonpeptide antagonist of the melanocortin-4 receptor

Receptor binding, behavioral, and electrophysiological profiles of nonpeptide corticotropin-releasing factor subtype 1 receptor antagonists CRA1000 and CRA1001

Design, synthesis, and structure–activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands

Structure–activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor

Non-monoamine-based approach for the treatment of depression and anxiety disorders

Identification of Arginine Analogues as Antagonists and Agonists for the Melanocortin-4 Receptor

Binding characteristics of [formula omitted]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors

Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106

Synthesis of Diphenylmethyl Analogues and Their Affinity for the Melanocortin-4 Receptor and the Serotonin Transporter

Identification of Arginine Analogues as Antagonists and Agonists for the Melanocortin-4 Receptor

Development of a Method for Evaluating Drug-Likeness and Ease of Synthesis Using a Data Set in Which Compounds Are Assigned Scores Based on Chemists' Intuition

Synthesis of Diphenylmethyl Analogues and Their Affinity for the Melanocortin-4 Receptor and the Serotonin Transporter

In vitro pharmacological profile of nonpeptide CRF1 receptor antagonists, CRA1000 and CRA1001

Non-Monoamine-Based Approach for the Treatment of Depression and Anxiety Disorders

Novel piperazines: Potent melanocortin-4 receptor antagonists with anxiolytic-like activity

MCL0042: A nonpeptidic MC4 receptor antagonist and serotonin reuptake inhibitor with anxiolytic- and antidepressant-like activity

Methods for finding, evaluating and selecting researchers for collaboration to enter a new business : How to search for suitable researchers for academic-industrial collaboration(<Special feature>The 11th information professional symposium: INFOPRO2014)

Chemical modification of aryl-1,2,3,6-tetrahydropyridinopyrimidine derivative to discover corticotropin-releasing factor1 receptor antagonists Aryl-1,2,3,6-tetrahydropyridino-purine, -3H-1,2,3-triazolo[4,5-d]pyrimidine, -purin-8-one, and -7H-pyrrolo[2,3-d]pyrimidine derivatives

将来の新事業展開のために連携すべき研究者を発掘・評価・選定する手法(<特集>第11回情報プロフェッショナルシンポジウム)

Synthesis and structure–affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor1 receptor antagonists

Design, synthesis and structure-affinity relationships of 4-methylidenepiperidine and 4-aryl-1,2,3,6-tetrahydropyridine derivatives as corticotropin-releasing factor1 receptor antagonists

Synthesis and structure–affinity relationships of 4-(5-Aryl-1,2,3,6-tetrahydropyridino)pyrimidine derivatives as corticotropin-releasing factor 1 receptor antagonists

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