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GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro

Hematology reports, 2018-05, Vol.10 (2), p.7419-7419

2018

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The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

Brain (London, England : 1878), 2011-03, Vol.134 (Pt 3), p.732-746

2011

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Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin

ACS medicinal chemistry letters, 2017-03, Vol.8 (3), p.321-326

2017

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Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

Frontiers in physiology, 2021-09, Vol.12, p.742784-742784

2021

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Death-associated Protein Kinase Is Activated by Dephosphorylation in Response to Cerebral Ischemia

The Journal of biological chemistry, 2005-12, Vol.280 (51), p.42290-42299

2005

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GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise

Hematology reports, 2016-09, Vol.8 (3), p.6637-6637

2016

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Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin-oxygen affinity modifiers

Drug design, development and therapy, 2018-01, Vol.12, p.1599-1607

2018

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Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP)

The European journal of neuroscience, 2006-06, Vol.23 (11), p.2847-2856

2006

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A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke

PloS one, 2013-07, Vol.8 (7), p.e69233-e69233

2013

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The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia

Physiological reports, 2019-03, Vol.7 (6), p.e14027-n/a

2019

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GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions

Clinical hemorheology and microcirculation, 2018-01, Vol.70 (1), p.95

2018

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Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease

British journal of clinical pharmacology, 2019-06, Vol.85 (6), p.1290-1302

2019

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Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease

Blood, 2022-11, Vol.140 (Supplement 1), p.5375-5376

2022

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GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease

Blood, 2022-11, Vol.140 (Supplement 1), p.5377-5378

2022

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Design, Synthesis, and Biological Characterization of a Peptide-Mimetic Antagonist for a Tethered-Ligand Receptor

Proceedings of the National Academy of Sciences - PNAS, 1999-10, Vol.96 (22), p.12257-12262

1999

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GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

British journal of haematology, 2016-10, Vol.175 (1), p.141-153

2016

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Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia

The European journal of neuroscience, 2008-05, Vol.27 (9), p.2444-2452

2008

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Inclacumab, a Fully Human Anti-P-Selectin Antibody, Directly Binds to PSGL-1 Binding Region and Demonstrates Robust and Durable Inhibition of Cell Adhesion

Blood, 2020-11, Vol.136 (Supplement 1), p.10-11

2020

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Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

Blood, 2020-11, Vol.136 (Supplement 1), p.9-10

2020

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GBT021601 Inhibits HbS Polymerization, Prevents RBC Sickling and Improves the Pathophysiology of Sickle Cell Disease in a Murine Model

Blood, 2020-11, Vol.136 (Supplement 1), p.7-8

2020

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A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors

Nature (London), 1992-11, Vol.360 (6400), p.161-163

1992

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Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice

American journal of physiology. Heart and circulatory physiology, 2021-08, Vol.321 (2), p.H400-H411

2021

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Pharmacological Increase of Hb-O2 Affinity with a Voxelotor Analog Does Not Decrease Brain Tissue pO2 or Limit O2 Extraction in Brain Tissues of Sickle Cell Mice

Blood, 2019-11, Vol.134 (Supplement_1), p.3564-3564

2019

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GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

Blood, 2015-12, Vol.126 (23), p.2172-2172

2015

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GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model

British journal of haematology, 2023-07, Vol.202 (1), p.173-183

2023

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GBT440 reverses sickling of sickled red blood cells under hypoxic conditions in vitro

The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke

Discovery of GBT440, an Orally Bioavailable R‑State Stabilizer of Sickle Cell Hemoglobin

Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

Death-associated Protein Kinase Is Activated by Dephosphorylation in Response to Cerebral Ischemia

GBT440 Inhibits Sickling of Sickle Cell Trait Blood Under In Vitro Conditions Mimicking Strenuous Exercise

Development and validation of an oxygen dissociation assay, a screening platform for discovering, and characterizing hemoglobin-oxygen affinity modifiers

Regulation of NMDA receptor trafficking and function by striatal-enriched tyrosine phosphatase (STEP)

A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke

The effect of the antisickling compound GBT1118 on the permeability of red blood cells from patients with sickle cell anemia

GBT440 improves red blood cell deformability and reduces viscosity of sickle cell blood under deoxygenated conditions

Pharmacokinetics and pharmacodynamics of voxelotor (GBT440) in healthy adults and patients with sickle cell disease

Increased Hemoglobin Affinity for Oxygen with GBT021601 Reduces Pulmonary Hypertension and Lung Vascular Inflammation in a Murine Model of Sickle Cell Disease

GBT021601 Prevents Microvascular Dysfunction and Improves Hypoxia-Reoxygenation-Induced Vaso-Occlusion in a Murine Model of Sickle Cell Disease

Design, Synthesis, and Biological Characterization of a Peptide-Mimetic Antagonist for a Tethered-Ligand Receptor

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia

Inclacumab, a Fully Human Anti-P-Selectin Antibody, Directly Binds to PSGL-1 Binding Region and Demonstrates Robust and Durable Inhibition of Cell Adhesion

Rheological Impact of GBT1118 Cessation in a Sickle Mouse Model

GBT021601 Inhibits HbS Polymerization, Prevents RBC Sickling and Improves the Pathophysiology of Sickle Cell Disease in a Murine Model

A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors

Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice

Pharmacological Increase of Hb-O2 Affinity with a Voxelotor Analog Does Not Decrease Brain Tissue pO2 or Limit O2 Extraction in Brain Tissues of Sickle Cell Mice

GBT440 Demonstrates High Specificity for Red Blood Cells in Nonclinical Species

GBT021601 improves red blood cell health and the pathophysiology of sickle cell disease in a murine model

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