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New inhibitors of glycogen phosphorylase as potential antidiabetic agents

Current medicinal chemistry, 2008-12, Vol.15 (28), p.2933

2008

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The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

The EMBO journal, 1997-11, Vol.16 (22), p.6646-6658

1997

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Structural Studies on Phospho-CDK2/Cyclin A Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism

Biochemistry (Easton), 2002-06, Vol.41 (23), p.7301-7311

2002

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Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies

Biochemistry (Easton), 1999-11, Vol.38 (44), p.14718-14730

1999

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Glycogen phosphorylase inhibitors: A free energy perturbation analysis of glucopyranose spirohydantoin analogues

Proteins, structure, function, and bioinformatics, 2005-12, Vol.61 (4), p.984-998

2005

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Ternary Complex Crystal Structures of Glycogen Phosphorylase with the Transition State Analogue Nojirimycin Tetrazole and Phosphate in the T and R States

Biochemistry (Easton), 1996-06, Vol.35 (23), p.7341-7355

1996

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Glucose analog inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes

Biochemistry (Easton), 1991-10, Vol.30 (42), p.10101-10116

1991

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Structural Basis of the Synergistic Inhibition of Glycogen Phosphorylase a by Caffeine and a Potential Antidiabetic Drug

Archives of biochemistry and biophysics, 2000-12, Vol.384 (2), p.245-254

2000

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A new allosteric site in glycogen phosphorylase b as a target for drug interactions

Structure (London), 2000-06, Vol.8 (6), p.575-584

2000

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Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site

The Journal of biological chemistry, 2000-11, Vol.275 (44), p.34566-34573

2000

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Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection

Acta crystallographica. Section D, Biological crystallography., 1995-07, Vol.51 (4), p.458-472

1995

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Crystallographic Studies on α- and β-D-glucopyranosyl Formamide Analogues, Inhibitors of Glycogen Phosphorylase

Biocatalysis and biotransformation, 2003-10, Vol.21 (4-5), p.233-242

2003

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Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure

Protein science, 1999-04, Vol.8 (4), p.741-749

1999

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N‐acetyl‐β‐D‐glucopyranosylamine: A potent T‐state inhibitor of glycogen phosphorylase. A comparison with α‐D‐glucose

Protein science, 1995-12, Vol.4 (12), p.2469-2477

1995

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Crystallographic Binding Studies on the Allosteric Inhibitor Glucose-6-Phosphate to T State Glycogen Phosphorylase b

Journal of molecular biology, 1993-07, Vol.232 (1), p.253-267

1993

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The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 Å resolution and 100 K: The role of the water structure and its contribution to binding

Protein science, 1998-04, Vol.7 (4), p.915-927

1998

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Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b

The EMBO journal, 1987-02, Vol.6 (2), p.539-546

1987

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Glycogen phosphorylase as a molecular target for type 2 diabetes therapy

Current protein & peptide science, 2002-12, Vol.3 (6), p.561

Oikonomakos, Nikos G

2002

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Advances in glycogen phosphorylase inhibitor design

Current opinion in investigational drugs (London, England : 2000), 2008-04, Vol.9 (4), p.379

2008

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The ammonium sulfate activation of phosphorylase b

FEBS letters, 1990-02, Vol.261 (1), p.23-27

1990

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Activator anion binding site in pyridoxal phosphorylase b: The binding of phosphite, phosphate, and fluorophosphate in the crystal

Protein science, 1996-12, Vol.5 (12), p.2416-2428

1996

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Sugar mimics from sugar lactones

Pure and applied chemistry, 1998-02, Vol.70 (2), p.279-284

1998

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The binding of D-gluconohydroximo-1,5-lactone to glycogen phosphorylase : kinetic, ultracentrifugation and crystallographic studies

Biochemical journal, 1991-03, Vol.274 (2), p.329-338

1991

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Channels at the catalytic site of glycogen phosphorylase b: binding and kinetic studies with the .beta.-glycosidase inhibitor D-gluconohydroximo-1,5-lactone N-phenylurethane

Biochemistry (Easton), 1988-09, Vol.27 (18), p.6733-6741

1988

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Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate

Biochemistry (Easton), 1984-11, Vol.23 (24), p.5862-5873

1984

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New inhibitors of glycogen phosphorylase as potential antidiabetic agents

The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition

Structural Studies on Phospho-CDK2/Cyclin A Bound to Nitrate, a Transition State Analogue: Implications for the Protein Kinase Mechanism

Catalytic Mechanism of Phosphorylase Kinase Probed by Mutational Studies

Glycogen phosphorylase inhibitors: A free energy perturbation analysis of glucopyranose spirohydantoin analogues

Ternary Complex Crystal Structures of Glycogen Phosphorylase with the Transition State Analogue Nojirimycin Tetrazole and Phosphate in the T and R States

Glucose analog inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes

Structural Basis of the Synergistic Inhibition of Glycogen Phosphorylase a by Caffeine and a Potential Antidiabetic Drug

A new allosteric site in glycogen phosphorylase b as a target for drug interactions

Flavopiridol Inhibits Glycogen Phosphorylase by Binding at the Inhibitor Site

Glucose analogue inhibitors of glycogen phosphorylase: from crystallographic analysis to drug prediction using GRID force-field and GOLPE variable selection

Crystallographic Studies on α- and β-D-glucopyranosyl Formamide Analogues, Inhibitors of Glycogen Phosphorylase

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure

N‐acetyl‐β‐D‐glucopyranosylamine: A potent T‐state inhibitor of glycogen phosphorylase. A comparison with α‐D‐glucose

Crystallographic Binding Studies on the Allosteric Inhibitor Glucose-6-Phosphate to T State Glycogen Phosphorylase b

The structure of a glycogen phosphorylase glucopyranose spirohydantoin complex at 1.8 Å resolution and 100 K: The role of the water structure and its contribution to binding

Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b

Glycogen phosphorylase as a molecular target for type 2 diabetes therapy

Advances in glycogen phosphorylase inhibitor design

The ammonium sulfate activation of phosphorylase b

Activator anion binding site in pyridoxal phosphorylase b: The binding of phosphite, phosphate, and fluorophosphate in the crystal

Sugar mimics from sugar lactones

The binding of D-gluconohydroximo-1,5-lactone to glycogen phosphorylase : kinetic, ultracentrifugation and crystallographic studies

Channels at the catalytic site of glycogen phosphorylase b: binding and kinetic studies with the .beta.-glycosidase inhibitor D-gluconohydroximo-1,5-lactone N-phenylurethane

Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate

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