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A Novel Inhibitor of Stearoyl-CoA Desaturase-1 Attenuates Hepatic Lipid Accumulation, Liver Injury and Inflammation in Model of Nonalcoholic Steatohepatitis

Biological and Pharmaceutical Bulletin, 2013/02/01, Vol.36(2), pp.259-267

2013

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Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells

Journal of leukocyte biology, 2004-02, Vol.75 (2), p.267-274

2004

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Cutting Edge: SR-PSOX/CXC Chemokine Ligand 16 Mediates Bacterial Phagocytosis by APCs Through its Chemokine Domain

The Journal of immunology (1950), 2003-08, Vol.171 (4), p.1647-1651

2003

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Potent Antidiabetic Effects of Rivoglitazone, a Novel Peroxisome Proliferator–Activated Receptor-γ Agonist, in Obese Diabetic Rodent Models

Journal of Pharmacological Sciences, 2009, Vol.111(2), pp.155-166

2009

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Pharmacology and in Vitro Profiling of a Novel Peroxisome Proliferator-Activated Receptor γ Ligand, Cerco-A

Biological and Pharmaceutical Bulletin, 2011/07/01, Vol.34(7), pp.1094-1104

2011

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CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats

European journal of pharmacology, 2008-12, Vol.601 (1), p.192-197

2008

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Increased Expression of the Sterol Regulatory Element-binding Protein-1 Gene in Insulin Receptor Substrate-2−/−Mouse Liver

The Journal of biological chemistry, 2001-10, Vol.276 (42), p.38337-38340

2001

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Molecular Design, Synthesis, and Hypoglycemic Activity of a Series of Thiazolidine-2,4-diones

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3052-3066

2000

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Identification of Molecular Target of AMP-activated Protein Kinase Activator by Affinity Purification and Mass Spectrometry

Analytical chemistry (Washington), 2005-04, Vol.77 (7), p.2050-2055

2005

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A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity

International immunology, 2000-04, Vol.12 (4), p.555-562

2000

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Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization

Bioorganic & medicinal chemistry, 2018-10, Vol.26 (18), p.5099-5117

2018

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Humanization of the Mouse Anti-Fas Antibody HFE7A and Crystal Structure of the Humanized HFE7A Fab Fragment

Biological and Pharmaceutical Bulletin, 2002, Vol.25(12), pp.1537-1545

2002

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Crystal Structure of the Antigen-Binding Fragment of Apoptosis-Inducing Mouse Anti-Human Fas Monoclonal Antibody HFE7A

Journal of biochemistry (Tokyo), 2002-01, Vol.131 (1), p.137-143

2002

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Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3H-spiro [1,5-benzoxazepine-2,4'-piperidine] analogs

European journal of medicinal chemistry, 2011-05, Vol.46 (5), p.1892-1896

2011

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Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4′-piperidine] analogs

European journal of medicinal chemistry, 2010-11, Vol.45 (11), p.4788-4796

2010

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Synthesis and biological evaluation of novel (−)-cercosporamide derivatives as potent selective PPARγ modulators

European journal of medicinal chemistry, 2012-08, Vol.54, p.522-533

2012

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Substituents at the naphthalene C3 position of (−)-Cercosporamide derivatives significantly affect the maximal efficacy as PPARγ partial agonists

Bioorganic & medicinal chemistry letters, 2012-02, Vol.22 (3), p.1348-1351

2012

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Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats

Bioorganic & medicinal chemistry letters, 2010, Vol.20 (1), p.341-345

2010

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Discovery of a novel selective PPARγ modulator from (−)-Cercosporamide derivatives

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2095-2098

2010

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Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.746-754

2010

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(−)-Cercosporamide derivatives as novel antihyperglycemic agents

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.724-726

2009

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Cloning and Expression of a Novel Murine Anti-human Fas Antibody

Bioscience, biotechnology, and biochemistry, 2000-09, Vol.64 (9), p.1903-1908

2000

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Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3 H-spiro[1,5-benzoxazepine-2,4′-piperidine] analogs

European journal of medicinal chemistry, 2011, Vol.46 (5), p.1892-1896

2011

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Discovery of a novel selective PPARg modulator from (-)-Cercosporamide derivatives

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (7), p.2095-2098

2010

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High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal β-cell HIT-T15

FEBS letters, 2003-06, Vol.545 (2), p.219-223

2003

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A Novel Inhibitor of Stearoyl-CoA Desaturase-1 Attenuates Hepatic Lipid Accumulation, Liver Injury and Inflammation in Model of Nonalcoholic Steatohepatitis

Cell surface-anchored SR-PSOX/CXC chemokine ligand 16 mediates firm adhesion of CXC chemokine receptor 6-expressing cells

Cutting Edge: SR-PSOX/CXC Chemokine Ligand 16 Mediates Bacterial Phagocytosis by APCs Through its Chemokine Domain

Potent Antidiabetic Effects of Rivoglitazone, a Novel Peroxisome Proliferator–Activated Receptor-γ Agonist, in Obese Diabetic Rodent Models

Pharmacology and in Vitro Profiling of a Novel Peroxisome Proliferator-Activated Receptor γ Ligand, Cerco-A

CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats

Increased Expression of the Sterol Regulatory Element-binding Protein-1 Gene in Insulin Receptor Substrate-2−/−Mouse Liver

Molecular Design, Synthesis, and Hypoglycemic Activity of a Series of Thiazolidine-2,4-diones

Identification of Molecular Target of AMP-activated Protein Kinase Activator by Affinity Purification and Mass Spectrometry

A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity

Discovery of DS-6930, a potent selective PPARγ modulator. Part II: Lead optimization

Humanization of the Mouse Anti-Fas Antibody HFE7A and Crystal Structure of the Humanized HFE7A Fab Fragment

Crystal Structure of the Antigen-Binding Fragment of Apoptosis-Inducing Mouse Anti-Human Fas Monoclonal Antibody HFE7A

Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3H-spiro [1,5-benzoxazepine-2,4'-piperidine] analogs

Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4′-piperidine] analogs

Synthesis and biological evaluation of novel (−)-cercosporamide derivatives as potent selective PPARγ modulators

Substituents at the naphthalene C3 position of (−)-Cercosporamide derivatives significantly affect the maximal efficacy as PPARγ partial agonists

Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats

Discovery of a novel selective PPARγ modulator from (−)-Cercosporamide derivatives

Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1′-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4′-piperidine]

(−)-Cercosporamide derivatives as novel antihyperglycemic agents

Cloning and Expression of a Novel Murine Anti-human Fas Antibody

Discovery of novel SCD1 inhibitors: 5-Alkyl-4,5-dihydro-3 H-spiro[1,5-benzoxazepine-2,4′-piperidine] analogs

Discovery of a novel selective PPARg modulator from (-)-Cercosporamide derivatives

High glucose potentiates palmitate-induced NO-mediated cytotoxicity through generation of superoxide in clonal β-cell HIT-T15

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