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Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid Leukemia

Frontiers in oncology, 2016-04, Vol.6, p.78-78

2016

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Set Protein Is Involved in FLT3 Membrane Trafficking

Cancers, 2023-04, Vol.15 (8), p.2233

2023

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Downregulation of PPP2R5E is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cells

Haematologica (Roma), 2013-09, Vol.98 (9), p.e103-e104

2013

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Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas

PloS one, 2011-11, Vol.6 (11), p.e26740

2011

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Antagonism of SET Using OP449 Enhances the Efficacy of Tyrosine Kinase Inhibitors and Overcomes Drug Resistance in Myeloid Leukemia

Clinical cancer research, 2014-04, Vol.20 (8), p.2092-2103

2014

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Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines

Cancer letters, 2013-07, Vol.334 (2), p.302-310

2013

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MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia

Oncotarget, 2017-08, Vol.8 (33), p.53989-54003

2017

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The role of the GATA2 transcription factor in normal and malignant hematopoiesis

Critical reviews in oncology/hematology, 2012-04, Vol.82 (1), p.1-17

2012

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Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia

Haematologica (Roma), 2012-04, Vol.97 (4), p.543-550

2012

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SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia

Blood, 2010-01, Vol.115 (3), p.615-625

2010

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GATA2 germline mutations impair GATA2 transcription, causing haploinsufficiency: functional analysis of the p.Arg396Gln mutation

The Journal of immunology (1950), 2015-03, Vol.194 (5), p.2190-2198

2015

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A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity

Cancer letters, 2020-01, Vol.468, p.1-13

2020

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NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder

Cancer research (Chicago, Ill.), 2004-04, Vol.64 (8), p.2673-2676

2004

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The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias

Cells (Basel, Switzerland), 2020-02, Vol.9 (3), p.544

2020

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Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia

PloS one, 2012-10, Vol.7 (10), p.e47717

2012

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CIP2A high expression is a poor prognostic factor in normal karyotype acute myeloid leukemia

Haematologica (Roma), 2015-05, Vol.100 (5), p.e183-e185

2015

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The MDS and EVI1 complex locus (MECOM) isoforms regulate their own transcription and have different roles in the transformation of hematopoietic stem and progenitor cells

Biochimica et biophysica acta. Gene regulatory mechanisms, 2017-06, Vol.1860 (6), p.721-729

2017

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A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia

Blood cancer journal (New York), 2020-01, Vol.10 (1), p.3-3, Article 3

2020

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MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia

Oncotarget, 2017-08, Vol.8 (33), p.53989-54003

2017

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Molecular heterogeneity in AML/MDS patients with 3q21q26 rearrangements

Genes chromosomes & cancer, 2004-07, Vol.40 (3), p.179-189

2004

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p53 Aberrations do not predict individual response to fludarabine in patients with B‐cell chronic lymphocytic leukaemia in advanced stages Rai III/IV

British journal of haematology, 2005-04, Vol.129 (1), p.53-59

2005

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Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia

Haematologica (Roma), 2011-10, Vol.96 (10), p.1448-1456

2011

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Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Oncotarget, 2016-12, Vol.7 (51), p.84214-84227

2016

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Regulation and role of the PP2A-B56 holoenzyme family in cancer

Biochimica et biophysica acta. Reviews on cancer, 2023-09, Vol.1878 (5), p.188953-188953, Article 188953

2023

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Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia

Proceedings of the National Academy of Sciences - PNAS, 2010-11, Vol.107 (44), p.E167-E168

2010

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Protein Phosphatase 2A as a Therapeutic Target in Acute Myeloid Leukemia

Set Protein Is Involved in FLT3 Membrane Trafficking

Downregulation of PPP2R5E is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cells

Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas

Antagonism of SET Using OP449 Enhances the Efficacy of Tyrosine Kinase Inhibitors and Overcomes Drug Resistance in Myeloid Leukemia

Edelfosine lipid nanosystems overcome drug resistance in leukemic cell lines

MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia

The role of the GATA2 transcription factor in normal and malignant hematopoiesis

Overexpression of SET is a recurrent event associated with poor outcome and contributes to protein phosphatase 2A inhibition in acute myeloid leukemia

SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia

GATA2 germline mutations impair GATA2 transcription, causing haploinsufficiency: functional analysis of the p.Arg396Gln mutation

A novel FTY720 analogue targets SET-PP2A interaction and inhibits growth of acute myeloid leukemia cells without inducing cardiac toxicity

NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder

The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias

Integration of SNP and mRNA arrays with microRNA profiling reveals that MiR-370 is upregulated and targets NF1 in acute myeloid leukemia

CIP2A high expression is a poor prognostic factor in normal karyotype acute myeloid leukemia

The MDS and EVI1 complex locus (MECOM) isoforms regulate their own transcription and have different roles in the transformation of hematopoietic stem and progenitor cells

A new regulatory mechanism of protein phosphatase 2A activity via SET in acute myeloid leukemia

MYC-dependent recruitment of RUNX1 and GATA2 on the SET oncogene promoter enhances PP2A inactivation in acute myeloid leukemia

Molecular heterogeneity in AML/MDS patients with 3q21q26 rearrangements

p53 Aberrations do not predict individual response to fludarabine in patients with B‐cell chronic lymphocytic leukaemia in advanced stages Rai III/IV

Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia

Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia

Regulation and role of the PP2A-B56 holoenzyme family in cancer

Silencing of hsa-miR-124 by EVI1 in cell lines and patients with acute myeloid leukemia

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