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Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Clinical pharmacology and therapeutics, 2014-02, Vol.95 (2), p.179-188

2014

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Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes

Drug metabolism and disposition, 1999-11, Vol.27 (11), p.1350

Obach, R S

1999

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Evaluation of Various Static In Vitro-In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug

Clinical pharmacology and therapeutics, 2014-02, Vol.95 (2), p.189-198

2014

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Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

Drug metabolism and disposition, 2019-09, Vol.47 (9), p.995-1003

2019

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Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression

The Journal of pharmacology and experimental therapeutics, 2000-07, Vol.294 (1), p.88

Obach, R S

2000

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Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study

Clinical pharmacology and therapeutics, 2008-04, Vol.83 (4), p.567-576

2008

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Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment

Xenobiotica, 2007-11, Vol.37 (10-11), p.1225-1256

2007

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Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol

Drug metabolism and disposition, 1997-12, Vol.25 (12), p.1359

Obach, R S

1997

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The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

The Journal of pharmacology and experimental therapeutics, 1997-10, Vol.283 (1), p.46

1997

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The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

Drug metabolism and disposition, 2016-10, Vol.44 (10), p.1569-1578

2016

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Metabolic characterization of the major human small intestinal cytochrome p450s

Drug metabolism and disposition, 2001-03, Vol.29 (3), p.347

2001

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Heterotropic Effects on Drug‐Metabolizing Enzyme Activities: In Vitro Curiosity Emerges as a Clinically Meaningful Phenomenon (Perhaps?)

Clinical pharmacology and therapeutics, 2012-03, Vol.91 (3), p.385-387

Obach, R S

2012

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An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software

Drug metabolism and disposition, 2016-10, Vol.44 (10), p.1653-1661

2016

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The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations

Drug metabolism and disposition, 1996-10, Vol.24 (10), p.1047

Obach, R S

1996

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Three-dimensional quantitative structure activity relationship computational approaches for prediction of human in vitro intrinsic clearance

The Journal of pharmacology and experimental therapeutics, 2000-11, Vol.295 (2), p.463

2000

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Metabolites in Safety Testing: "MIST" for the Clinical Pharmacologist

Clinical pharmacology and therapeutics, 2010-03, Vol.87 (3), p.345-350

2010

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Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation

Drug metabolism and disposition, 2000-09, Vol.28 (9), p.1069

Obach, R S

2000

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Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs

Drug metabolism and disposition, 2001-12, Vol.29 (12), p.1599

Obach, R S

2001

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Human Liver Aldehyde Oxidase: Inhibition by 239 Drugs

Journal of clinical pharmacology, 2004-01, Vol.44 (1), p.7-19

2004

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Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine

Drug metabolism and disposition, 1998-08, Vol.26 (8), p.764

1998

Volltextzugriff (PDF)

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

Drug metabolism and disposition, 2003-07, Vol.31 (7), p.815

2003

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The effect of CP‐99994 on the responses to provocative motion in the cat

British journal of pharmacology, 1997-01, Vol.120 (1), p.116-120

1997

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Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing

Drug metabolism and disposition, 2005-10, Vol.33 (10), p.1409

2005

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Strategy for genotoxicity testing—Metabolic considerations

Mutation research, 2007-02, Vol.627 (1), p.59-77

2007

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Examination of 209 Drugs for Inhibition of Cytochrome P450 2C8

Journal of clinical pharmacology, 2005-01, Vol.45 (1), p.68-78

2005

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Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes

Evaluation of Various Static In Vitro-In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression

Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study

Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug-drug interaction risk assessment

Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

Metabolic characterization of the major human small intestinal cytochrome p450s

Heterotropic Effects on Drug‐Metabolizing Enzyme Activities: In Vitro Curiosity Emerges as a Clinically Meaningful Phenomenon (Perhaps?)

An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software

The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations

Three-dimensional quantitative structure activity relationship computational approaches for prediction of human in vitro intrinsic clearance

Metabolites in Safety Testing: "MIST" for the Clinical Pharmacologist

Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation

Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs

Human Liver Aldehyde Oxidase: Inhibition by 239 Drugs

Cytochrome P4502D6 catalyzes the O-demethylation of the psychoactive alkaloid ibogaine to 12-hydroxyibogamine

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

The effect of CP‐99994 on the responses to provocative motion in the cat

Seeing through the mist: abundance versus percentage. Commentary on metabolites in safety testing

Strategy for genotoxicity testing—Metabolic considerations

Examination of 209 Drugs for Inhibition of Cytochrome P450 2C8

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