UB Paderborn / Katalog / Suche / in CDI

Discovery of the Potent and Selective M1 PAM-Agonist N‑[(3R,4S)‑3-Hydroxytetrahydro‑2H‑pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6313-6328

2016

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Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

Organic process research & development, 2022-03, Vol.26 (3), p.616-623

2022

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Design and Synthesis of γ- and δ‑Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1‑Selective PAM with Weak Agonist Activity

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6649-6663

2017

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Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life

ACS medicinal chemistry letters, 2023-10, Vol.14 (10), p.1427-1433

2023

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Design and optimization of selective azaindole amide M1 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.650-655

2016

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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.3008-3026

2018

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Advances in the development of novel aggrecanase inhibitors

Expert opinion on therapeutic patents, 2011-01, Vol.21 (1), p.1-12

2011

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Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (21), p.5659-5663

2006

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Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4796-4799

2006

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Design and optimization of selective azaindole amide M 1 positive allosteric modulators

Bioorganic & medicinal chemistry letters, 2016-01, Vol.26 (2), p.650-655

2016

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Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors

Bioorganic & medicinal chemistry, 2007-02, Vol.15 (3), p.1311-1322

2007

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Design and Synthesis of γ- and δ-Lactam M 1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M 1 -Selective PAM with Weak Agonist Activity

Journal of medicinal chemistry, 2017-08, Vol.60 (15), p.6649-6663

2017

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Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4728-4732

2006

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Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A

Journal of organic chemistry, 1998-07, Vol.63 (14), p.4732-4740

1998

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Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4291-4294

2005

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Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors

Bioorganic & medicinal chemistry, 2006-12, Vol.14 (23), p.7880-7892

2006

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Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1β converting enzyme (ICE) inhibitors

Bioorganic & medicinal chemistry letters, 2006-08, Vol.16 (16), p.4233-4236

2006

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Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: Inhibition of interleukin-1β-converting enzyme

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4322-4326

2005

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Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors

Bioorganic & medicinal chemistry letters, 2005-12, Vol.15 (24), p.5434-5438

2005

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Synthesis of (±)-Gymnomitrol. Mn(OAc)3-Initiated Free-Radical Cyclization of Alkynyl Ketones

Journal of organic chemistry, 1997-04, Vol.62 (7), p.1970-1975

1997

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Synthesis of (+/-)-Gymnomitrol. Mn(OAc)(3)-Initiated Free-Radical Cyclization of Alkynyl Ketones

Journal of organic chemistry, 1997-04, Vol.62 (7), p.1970-1975

1997

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Stereochemical Dependence of Base-Catalyzed Cleavage of Cyclic Peroxy Ketals

Journal of organic chemistry, 1994-04, Vol.59 (7), p.1726-1729

1994

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Synthesis of (±)-Allocyathin B 2 and (+)-Erinacine A

Journal of organic chemistry, 1998-07, Vol.63 (14), p.4732-4740

1998

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Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A

Journal of the American Chemical Society, 1996-08, Vol.118 (32), p.7644-7645

1996

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Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4728

2006

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Discovery of the Potent and Selective M1 PAM-Agonist N‑[(3R,4S)‑3-Hydroxytetrahydro‑2H‑pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1‑Oxa-8-azaspiro[4.5]decan-3-amine

Design and Synthesis of γ- and δ‑Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1‑Selective PAM with Weak Agonist Activity

Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life

Design and optimization of selective azaindole amide M1 positive allosteric modulators

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation

Advances in the development of novel aggrecanase inhibitors

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

Design and optimization of selective azaindole amide M 1 positive allosteric modulators

Synthesis and evaluation of unsaturated caprolactams as interleukin-1β converting enzyme (ICE) inhibitors

Design and Synthesis of γ- and δ-Lactam M 1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M 1 -Selective PAM with Weak Agonist Activity

Synthesis and evaluation of thiazepines as interleukin-1β converting enzyme (ICE) inhibitors

Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A

Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis

Synthesis and evaluation of novel 8,5-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme (ICE) inhibitors

Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1β converting enzyme (ICE) inhibitors

Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: Inhibition of interleukin-1β-converting enzyme

Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors

Synthesis of (±)-Gymnomitrol. Mn(OAc)3-Initiated Free-Radical Cyclization of Alkynyl Ketones

Synthesis of (+/-)-Gymnomitrol. Mn(OAc)(3)-Initiated Free-Radical Cyclization of Alkynyl Ketones

Stereochemical Dependence of Base-Catalyzed Cleavage of Cyclic Peroxy Ketals

Synthesis of (±)-Allocyathin B 2 and (+)-Erinacine A

Synthesis of (±)-Allocyathin B2 and (+)-Erinacine A

Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors

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