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Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

Pharmaceutical research, 2010, Vol.27 (1), p.65-71

2010

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Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics

Protein engineering, design and selection, 2015-10, Vol.28 (10), p.385-393

2015

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Engineering a targeted delivery platform using Centyrins

Protein engineering, design and selection, 2016-12, Vol.29 (12), p.563

2016

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Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions

Protein engineering, design and selection, 2014-10, Vol.27 (10), p.419-429

2014

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Mechanisms of self-association of a human monoclonal antibody CNTO607

Protein engineering, design and selection, 2012-10, Vol.25 (10), p.531-538

2012

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Structure-based engineering of a monoclonal antibody for improved solubility

Protein engineering, design and selection, 2010-08, Vol.23 (8), p.643-651

2010

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Conformational flexibility of an anti-IL-13 DARPin

Protein engineering, design and selection, 2017-01, Vol.30 (1), p.31-37

2017

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GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE3-Leiden mice

PloS one, 2012-11, Vol.7 (11), p.e49152

2012

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Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors

Bioconjugate chemistry, 2017-11, Vol.28 (11), p.2865-2873

2017

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Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin

Proteins, structure, function, and bioinformatics, 2015-06, Vol.83 (6), p.1191-1197

2015

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C-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffold

Proteins, structure, function, and bioinformatics, 2014-07, Vol.82 (7), p.1359-1369

2014

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N-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions

Proteins, structure, function, and bioinformatics, 2014-07, Vol.82 (7), p.1527-1533

2014

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Protein Design: A Hierarchic Approach

Science (American Association for the Advancement of Science), 1995-11, Vol.270 (5238), p.935-941

1995

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Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis

Diabetes (New York, N.Y.), 2008-07, Vol.57 (7), p.1926-1934

2008

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Centyrin ligands for extrahepatic delivery of siRNA

Molecular therapy, 2021-06, Vol.29 (6), p.2053-2066

2021

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A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

Science (American Association for the Advancement of Science), 1990-11, Vol.250 (4981), p.646-651

1990

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Design of novel FN3 domains with high stability by a consensus sequence approach

Protein engineering, design and selection, 2012-03, Vol.25 (3), p.107-117

2012

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LC/MS/MS Bioanalysis of Protein–Drug ConjugatesThe Importance of Incorporating Succinimide Hydrolysis Products

Analytical chemistry (Washington), 2018-04, Vol.90 (8), p.5314-5321

2018

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CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice

The Journal of pharmacology and experimental therapeutics, 2009-01, Vol.328 (1), p.240-248

2009

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Centyrin-targeted glycogen synthase-1 siRNA conjugates: A novel therapeutic modality for the treatment of Pompe disease

Molecular genetics and metabolism, 2023-02, Vol.138 (2), p.107337, Article 107337

2023

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An Early Intermediate in the Folding Reaction of the B1 Domain of Protein G Contains a Native-like Core

Biochemistry (Easton), 1997-11, Vol.36 (47), p.14277-14283

1997

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Aspartyl β-Hydroxylase (Asph) and an Evolutionarily Conserved Isoform of Asph Missing the Catalytic Domain Share Exons with Junctin

The Journal of biological chemistry, 2000-12, Vol.275 (50), p.39543-39554

2000

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Inhalation Delivery of Protein Therapeutics

Inflammation & allergy drug targets, 2013-04, Vol.12 (2), p.81-87

2013

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A novel siRNA targeting and delivery platform inhibits glycogen synthesis and reduces glycogen levels in skeletal and cardiac muscle in a mouse model of Pompe disease

Molecular genetics and metabolism, 2024-02, Vol.141 (2), p.107994, Article 107994

2024

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Abstract 1825: Tumor-targeted knockdown of KRAS mutants with novel Centyrin:siRNA conjugates

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.1825-1825

2020

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Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates

Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics

Engineering a targeted delivery platform using Centyrins

Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions

Mechanisms of self-association of a human monoclonal antibody CNTO607

Structure-based engineering of a monoclonal antibody for improved solubility

Conformational flexibility of an anti-IL-13 DARPin

GLP-1 receptor activation inhibits VLDL production and reverses hepatic steatosis by decreasing hepatic lipogenesis in high-fat-fed APOE3-Leiden mice

Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors

Induced conformational change in human IL-4 upon binding of a signal-neutralizing DARPin

C-terminal β-strand swapping in a consensus-derived fibronectin Type III scaffold

N-terminal β-strand swapping in a consensus-derived alternative scaffold driven by stabilizing hydrophobic interactions

Protein Design: A Hierarchic Approach

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis

Centyrin ligands for extrahepatic delivery of siRNA

A Thermodynamic Scale for the Helix-Forming Tendencies of the Commonly Occurring Amino Acids

Design of novel FN3 domains with high stability by a consensus sequence approach

LC/MS/MS Bioanalysis of Protein–Drug ConjugatesThe Importance of Incorporating Succinimide Hydrolysis Products

CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice

Centyrin-targeted glycogen synthase-1 siRNA conjugates: A novel therapeutic modality for the treatment of Pompe disease

An Early Intermediate in the Folding Reaction of the B1 Domain of Protein G Contains a Native-like Core

Aspartyl β-Hydroxylase (Asph) and an Evolutionarily Conserved Isoform of Asph Missing the Catalytic Domain Share Exons with Junctin

Inhalation Delivery of Protein Therapeutics

A novel siRNA targeting and delivery platform inhibits glycogen synthesis and reduces glycogen levels in skeletal and cardiac muscle in a mouse model of Pompe disease

Abstract 1825: Tumor-targeted knockdown of KRAS mutants with novel Centyrin:siRNA conjugates

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