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Assisted Design of Antibody and Protein Therapeutics (ADAPT)

PloS one, 2017-07, Vol.12 (7), p.e0181490

2017

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Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

PloS one, 2019-12, Vol.14 (12), p.e0226593

2019

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Identification of high-quality cancer prognostic markers and metastasis network modules

Nature communications, 2010-07, Vol.1 (4), p.1-8, Article 34

2010

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Structures of TGF-β receptor complexes: implications for function and therapeutic intervention using ligand traps

Current pharmaceutical biotechnology, 2011-12, Vol.12 (12), p.2081-2098

2011

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Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma

Cancer research (Chicago, Ill.), 2012-10, Vol.72 (19), p.4909-4919

2012

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IGFBP-4 Anti-Angiogenic and Anti-Tumorigenic Effects Are Associated with Anti-Cathepsin B Activity

Neoplasia (New York, N.Y.), 2013-05, Vol.15 (5), p.554-567

2013

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Binding Properties of the Transforming Growth Factor‑β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

Biochemistry (Easton), 2016-12, Vol.55 (49), p.6880-6896

2016

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Fetal and adult human skin fibroblasts display intrinsic differences in contractile capacity

Journal of cellular physiology, 2001-08, Vol.188 (2), p.211-222

2001

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Molecular imaging of breast tumors using a near-infrared fluorescently labeled clusterin binding peptide

International journal of cancer, 2012-09, Vol.131 (5), p.E681-E692

2012

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Real-Time Monitoring of the Interactions of Two-Stranded de Novo Designed Coiled-Coils: Effect of Chain Length on the Kinetic and Thermodynamic Constants of Binding

Biochemistry (Easton), 2003-02, Vol.42 (6), p.1754-1763

2003

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crystal structure and dimerization interface of GADD45γ

Proceedings of the National Academy of Sciences - PNAS, 2008-05, Vol.105 (18), p.6566-6571

2008

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Link Protein Has Greater Affinity for Versican than Aggrecan

The Journal of biological chemistry, 2004-03, Vol.279 (13), p.12060-12066

2004

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Analysis of acquired resistance to metronomic oral topotecan chemotherapy plus pazopanib after prolonged preclinical potent responsiveness in advanced ovarian cancer

Angiogenesis (London), 2014-07, Vol.17 (3), p.661-673

2014

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A ligand-pseudoreceptor system based on de novo designed peptides for the generation of adenoviral vectors with altered tropism

The journal of gene medicine, 2008-04, Vol.10 (4), p.355-367

2008

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A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

Oncotarget, 2016-12, Vol.7 (52), p.86087-86102

2016

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Engineering and therapeutic application of single-chain bivalent TGF-β family traps

Molecular cancer therapeutics, 2012-07, Vol.11 (7), p.1477-1487

2012

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TβR-II Discriminates the High- and Low-Affinity TGF-β Isoforms via Two Hydrogen-Bonded Ion Pairs

Biochemistry (Easton), 2009-03, Vol.48 (10), p.2146-2155

2009

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Transforming Growth Factor-beta (TGF-β) Binding to the Extracellular Domain of the Type II TGF-β Receptor: Receptor Capture on a Biosensor Surface Using a New Coiled-coil Capture System Demonstrates that Avidity Contributes Significantly to High Affinity Binding

Journal of molecular biology, 2003-05, Vol.328 (5), p.1173-1183

2003

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Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling

The Journal of biological chemistry, 2001-07, Vol.276 (27), p.24627-24637

2001

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Real-time Monitoring of the Interactions of Transforming Growth Factor-β (TGF-β) Isoforms with Latency-associated Protein and the Ectodomains of the TGF-β Type II and III Receptors Reveals Different Kinetic Models and Stoichiometries of Binding

The Journal of biological chemistry, 2001-08, Vol.276 (32), p.29632-29643

2001

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Correction to Binding Properties of the Transforming Growth Factor‑β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

Biochemistry (Easton), 2017-07, Vol.56 (28), p.3689-3689

2017

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Enhancement of the Antagonistic Potency of Transforming Growth Factor-β Receptor Extracellular Domains by Coiled Coil-induced Homo- and Heterodimerization

The Journal of biological chemistry, 2004-06, Vol.279 (25), p.26013-26018

2004

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Superagonistic Activation of ErbB-1 by EGF-related Growth Factors with Enhanced Association and Dissociation Rate Constants

The Journal of biological chemistry, 2000-09, Vol.275 (35), p.26748

Lenferink, A. E.G.

2000

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Analysis of the contribution of receptor subdomains to the cooperative binding and internalization of transforming growth factor-β (TGF-β) type I and type II receptors

Experimental cell research, 2008-08, Vol.314 (14), p.2553-2568

2008

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Expression of TGF-β type II receptor antisense RNA impairs TGF-β1 signaling in vitro and promotes mammary gland differentiation in vivo

International journal of cancer, 2003-12, Vol.107 (6), p.919-928

2003

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Assisted Design of Antibody and Protein Therapeutics (ADAPT)

Binding and functional profiling of antibody mutants guides selection of optimal candidates as antibody drug conjugates

Identification of high-quality cancer prognostic markers and metastasis network modules

Structures of TGF-β receptor complexes: implications for function and therapeutic intervention using ligand traps

Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma

IGFBP-4 Anti-Angiogenic and Anti-Tumorigenic Effects Are Associated with Anti-Cathepsin B Activity

Binding Properties of the Transforming Growth Factor‑β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

Fetal and adult human skin fibroblasts display intrinsic differences in contractile capacity

Molecular imaging of breast tumors using a near-infrared fluorescently labeled clusterin binding peptide

Real-Time Monitoring of the Interactions of Two-Stranded de Novo Designed Coiled-Coils: Effect of Chain Length on the Kinetic and Thermodynamic Constants of Binding

crystal structure and dimerization interface of GADD45γ

Link Protein Has Greater Affinity for Versican than Aggrecan

Analysis of acquired resistance to metronomic oral topotecan chemotherapy plus pazopanib after prolonged preclinical potent responsiveness in advanced ovarian cancer

A ligand-pseudoreceptor system based on de novo designed peptides for the generation of adenoviral vectors with altered tropism

A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands

Engineering and therapeutic application of single-chain bivalent TGF-β family traps

TβR-II Discriminates the High- and Low-Affinity TGF-β Isoforms via Two Hydrogen-Bonded Ion Pairs

Transforming Growth Factor-beta (TGF-β) Binding to the Extracellular Domain of the Type II TGF-β Receptor: Receptor Capture on a Biosensor Surface Using a New Coiled-coil Capture System Demonstrates that Avidity Contributes Significantly to High Affinity Binding

Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling

Real-time Monitoring of the Interactions of Transforming Growth Factor-β (TGF-β) Isoforms with Latency-associated Protein and the Ectodomains of the TGF-β Type II and III Receptors Reveals Different Kinetic Models and Stoichiometries of Binding

Correction to Binding Properties of the Transforming Growth Factor‑β Coreceptor Betaglycan: Proposed Mechanism for Potentiation of Receptor Complex Assembly and Signaling

Enhancement of the Antagonistic Potency of Transforming Growth Factor-β Receptor Extracellular Domains by Coiled Coil-induced Homo- and Heterodimerization

Superagonistic Activation of ErbB-1 by EGF-related Growth Factors with Enhanced Association and Dissociation Rate Constants

Analysis of the contribution of receptor subdomains to the cooperative binding and internalization of transforming growth factor-β (TGF-β) type I and type II receptors

Expression of TGF-β type II receptor antisense RNA impairs TGF-β1 signaling in vitro and promotes mammary gland differentiation in vivo

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