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CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development

Journal of organic chemistry, 2012-03, Vol.77 (5), p.2299-2309

2012

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Enantioselective Hydrogenation of N−H Imines

Journal of the American Chemical Society, 2009-07, Vol.131 (29), p.9882-9883

2009

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Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2‑a]pyrimidine Isomers

Organic letters, 2019-12, Vol.21 (23), p.9527-9531

2019

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Modeling a Crowdsourced Definition of Molecular Complexity

Journal of chemical information and modeling, 2014-06, Vol.54 (6), p.1604-1616

2014

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A Practical Enantioselective Synthesis of Odanacatib, a Potent Cathepsin K Inhibitor, via Triflate Displacement of an α-Trifluoromethylbenzyl Triflate

Journal of organic chemistry, 2009-02, Vol.74 (4), p.1605-1610

2009

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Scalable Synthesis of a Prostaglandin EP4 Receptor Antagonist

Journal of organic chemistry, 2010-06, Vol.75 (12), p.4078-4085

2010

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A Practical Synthesis of m-Prostaglandin E Synthase-1 Inhibitor MK-7285

Journal of organic chemistry, 2009-10, Vol.74 (20), p.7790-7797

2009

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A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate

Journal of organic chemistry, 2011-02, Vol.76 (4), p.1062-1071

2011

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Unprecedented Catalytic Asymmetric Reduction of N−H Imines

Organic letters, 2005-01, Vol.7 (2), p.355-358

2005

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Chemoselective Staudinger Strategy in the Practical, Fit for Purpose, Gram-Scale Synthesis of an HCV RNA Polymerase Inhibitor

Synlett, 2011-01, Vol.2011 (1), p.57-60

2011

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Practical Synthesis of a Potent Bradykinin B1 Antagonist via Enantioselective Hydrogenation of a Pyridyl N-Acyl Enamide

Journal of organic chemistry, 2009-06, Vol.74 (12), p.4547-4553

2009

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Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α-Amino Esters

Angewandte Chemie (International ed.), 2007-01, Vol.46 (11), p.1839-1842

2007

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Preparative Scale Synthesis of the Biaryl Core of Anacetrapib via a Ruthenium-Catalyzed Direct Arylation Reaction: Unexpected Effect of Solvent Impurity on the Arylation Reaction

Journal of organic chemistry, 2011-03, Vol.76 (5), p.1436-1439

2011

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Convergent, Fit-For-Purpose, Kilogram-Scale Synthesis of a 5-Lipoxygenase Inhibitor

Organic process research & development, 2012-02, Vol.16 (2), p.214-219

2012

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Development of a Practical Synthesis of Stearoyl-CoA Desaturase (SCD1) Inhibitor MK-8245

Organic process research & development, 2011-09, Vol.15 (5), p.1073-1080

2011

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Superior Reactivity of Thiosemicarbazides in the Synthesis of 2-Amino-1,3,4-oxadiazoles

Journal of organic chemistry, 2006-12, Vol.71 (25), p.9548-9551

2006

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Convergent Kilo-Scale Synthesis of a Potent Renin Inhibitor for the Treatment of Hypertension

Organic process research & development, 2011-09, Vol.15 (5), p.1138-1148

2011

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Remote Electronic Control in the Regioselective Reduction of Succinimides: A Practical, Scalable Synthesis of EP4 Antagonist MF-310

Journal of organic chemistry, 2009-09, Vol.74 (17), p.6863-6866

2009

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Practical Synthesis of a Renin Inhibitor via a Diastereoselective Dieckmann Cyclization

Organic letters, 2010-11, Vol.12 (22), p.5146-5149

2010

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A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate

Journal of organic chemistry, 2012-01, Vol.77 (1), p.813-813

2012

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A Robust Kilo-Scale Synthesis of Doravirine

Organic process research & development, 2016-08, Vol.20 (8), p.1476-1481

2016

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Practical Asymmetric Synthesis of a Potent PDE4 Inhibitor via Stereoselective Enolate Alkylation of a Chiral Aryl−Heteroaryl Secondary Tosylate

Journal of organic chemistry, 2005-04, Vol.70 (8), p.3021-3030

2005

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A Practical Synthesis of 5-Lipoxygenase Inhibitor MK-0633

Journal of organic chemistry, 2010-06, Vol.75 (12), p.4154-4160

2010

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Correction to Convergent Kilo-Scale Synthesis of a Potent Renin Inhibitor for the Treatment of Hypertension

Organic process research & development, 2012-06, Vol.16 (6), p.1241-1241

2012

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Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

Organic process research & development, 2013-01, Vol.17 (1), p.61-68

2013

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CRTH2 Antagonist MK-7246: A Synthetic Evolution from Discovery through Development

Enantioselective Hydrogenation of N−H Imines

Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2‑a]pyrimidine Isomers

Modeling a Crowdsourced Definition of Molecular Complexity

A Practical Enantioselective Synthesis of Odanacatib, a Potent Cathepsin K Inhibitor, via Triflate Displacement of an α-Trifluoromethylbenzyl Triflate

Scalable Synthesis of a Prostaglandin EP4 Receptor Antagonist

A Practical Synthesis of m-Prostaglandin E Synthase-1 Inhibitor MK-7285

A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate

Unprecedented Catalytic Asymmetric Reduction of N−H Imines

Chemoselective Staudinger Strategy in the Practical, Fit for Purpose, Gram-Scale Synthesis of an HCV RNA Polymerase Inhibitor

Practical Synthesis of a Potent Bradykinin B1 Antagonist via Enantioselective Hydrogenation of a Pyridyl N-Acyl Enamide

Diastereoselective Reductive Amination of Aryl Trifluoromethyl Ketones and α-Amino Esters

Preparative Scale Synthesis of the Biaryl Core of Anacetrapib via a Ruthenium-Catalyzed Direct Arylation Reaction: Unexpected Effect of Solvent Impurity on the Arylation Reaction

Convergent, Fit-For-Purpose, Kilogram-Scale Synthesis of a 5-Lipoxygenase Inhibitor

Development of a Practical Synthesis of Stearoyl-CoA Desaturase (SCD1) Inhibitor MK-8245

Superior Reactivity of Thiosemicarbazides in the Synthesis of 2-Amino-1,3,4-oxadiazoles

Convergent Kilo-Scale Synthesis of a Potent Renin Inhibitor for the Treatment of Hypertension

Remote Electronic Control in the Regioselective Reduction of Succinimides: A Practical, Scalable Synthesis of EP4 Antagonist MF-310

Practical Synthesis of a Renin Inhibitor via a Diastereoselective Dieckmann Cyclization

A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate

A Robust Kilo-Scale Synthesis of Doravirine

Practical Asymmetric Synthesis of a Potent PDE4 Inhibitor via Stereoselective Enolate Alkylation of a Chiral Aryl−Heteroaryl Secondary Tosylate

A Practical Synthesis of 5-Lipoxygenase Inhibitor MK-0633

Correction to Convergent Kilo-Scale Synthesis of a Potent Renin Inhibitor for the Treatment of Hypertension

Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist

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