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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Nature (London), 2012-11, Vol.491 (7424), p.458-462

2012

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Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design

Drug discovery today, 2019-05, Vol.24 (5), p.1081-1086

2019

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Embolization of a Proximal Pulmonary Artery Pseudoaneurysm in a Cavitary Lung Cancer

Journal of vascular and interventional radiology, 2022-06, Vol.33 (6), p.741-741

2022

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X‑ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor

Journal of medicinal chemistry, 2022-09, Vol.65 (18), p.12319-12333

2022

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Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2

Molecular cancer therapeutics, 2020-02, Vol.19 (2), p.525-539

2020

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Electronic referrals for virtual fracture clinic service using the National Integrated Medical Imaging System (NIMIS)

Irish journal of medical science, 2019-05, Vol.188 (2), p.371-377

2019

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Crystal structure of human CDK4 in complex with a D-type cyclin

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (11), p.4166-4170

2009

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Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Journal of medicinal chemistry, 2009-01, Vol.52 (2), p.379-388

2009

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ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Molecular cancer therapeutics, 2021-10, Vol.20 (10), p.1757-1768

2021

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Fragment-based approaches to the discovery of kinase inhibitors

Methods in enzymology, 2014, Vol.548, p.69-92

2014

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4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6

Journal of medicinal chemistry, 2010-11, Vol.53 (22), p.7938-7957

2010

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General practitioner attitudes and experiences of orthopaedic services in the Irish midlands

Irish journal of medical science, 2019-08, Vol.188 (3), p.735-741

2019

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Evolving Empire: America's "Emirates" Strategy in the Persian Gulf

International studies perspectives, 2007-05, Vol.8 (2), p.137-151

2007

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The Association of Gastrocnemius Tightness, Genu Valgum and Hallux Valgus: A Prospective Case-Control Study

The Journal of foot and ankle surgery, 2021-03, Vol.60 (2), p.258-261

2021

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Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design

Structure (London), 2024-08, Vol.32 (8), p.1040-1048.e3

2024

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Biochemical and biophysical characterization of pyruvate kinase M2 activation by L-serine

Cancer & metabolism, 2014-05, Vol.2 (S1), p.P12-P12, Article P12

2014

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Telomerases

Current opinion in structural biology, 1999-02, Vol.9 (1), p.56-65

1999

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Engineering and purification of a thermostable, high-yield, variant of PfCRT, the Plasmodium falciparum chloroquine resistance transporter

Protein expression and purification, 2018-01, Vol.141, p.7-18

2018

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Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probeElectronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02754d

2018-11

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Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02754d

Chemical science (Cambridge), 2018-09, Vol.9 (45), p.8608-8618

2018

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High throughput protein crystallography: Developments in crystallisation, data collection and data processing

Drug discovery today. Technologies, 2006-12, Vol.3 (4), p.451-456

2006

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Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Crystallographic screening using ultra-low-molecular-weight ligands to guide drug design

Embolization of a Proximal Pulmonary Artery Pseudoaneurysm in a Cavitary Lung Cancer

X‑ray Screening of an Electrophilic Fragment Library and Application toward the Development of a Novel ERK 1/2 Covalent Inhibitor

Dual-Mechanism ERK1/2 Inhibitors Exploit a Distinct Binding Mode to Block Phosphorylation and Nuclear Accumulation of ERK1/2

Electronic referrals for virtual fracture clinic service using the National Integrated Medical Imaging System (NIMIS)

Crystal structure of human CDK4 in complex with a D-type cyclin

Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity

Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β‑Glucocerebrosidase

Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2

ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK

Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2

Identification of N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design

Fragment-based approaches to the discovery of kinase inhibitors

4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6

General practitioner attitudes and experiences of orthopaedic services in the Irish midlands

Evolving Empire: America's "Emirates" Strategy in the Persian Gulf

The Association of Gastrocnemius Tightness, Genu Valgum and Hallux Valgus: A Prospective Case-Control Study

Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design

Biochemical and biophysical characterization of pyruvate kinase M2 activation by L-serine

Telomerases

Engineering and purification of a thermostable, high-yield, variant of PfCRT, the Plasmodium falciparum chloroquine resistance transporter

Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probeElectronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02754d

Quantitation of ERK1/2 inhibitor cellular target occupancies with a reversible slow off-rate probe† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02754d

High throughput protein crystallography: Developments in crystallisation, data collection and data processing

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