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Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

PloS one, 2018-08, Vol.13 (8), p.e0202350-e0202350

2018

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Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice

Journal of endocrinology, 2022-11, Vol.255 (2), p.91-101

2022

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Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides

Food research international, 2018-04, Vol.106, p.598-606

2018

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Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity

Food research international, 2020-05, Vol.131, p.108989-108989, Article 108989

2020

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Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation

Diabetes, obesity & metabolism, 2020-12, Vol.22 (12), p.2468-2478

2020

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Chronic apelin analogue administration is more effective than established incretin therapies for alleviating metabolic dysfunction in diabetic db/db mice

Molecular and cellular endocrinology, 2020-03, Vol.504, p.110695, Article 110695

2020

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A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation

Diabetologia, 2014-09, Vol.57 (9), p.1927-1936

2014

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Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update

Clinical Medicine Insights: Endocrinology and Diabetes, 2022-02, Vol.15, p.11795514221074679-11795514221074679

2022

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Acylated apelin-13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties

Biochemical pharmacology, 2017-12, Vol.146, p.165-173

2017

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Metabolic effects of combined glucagon receptor antagonism and glucagon-like peptide-1 receptor agonism in high fat fed mice

Biochimie, 2022-08, Vol.199, p.60-67

2022

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Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis

Autophagy, 2022-04, Vol.18 (4), p.799-815

2022

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Beneficial long‐term antidiabetic actions of N‐ and C‐terminally modified analogues of apelin‐13 in diet‐induced obese diabetic mice

Diabetes, obesity & metabolism, 2018-02, Vol.20 (2), p.319-327

2018

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Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro3)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes

Diabetes (New York, N.Y.), 2005-08, Vol.54 (8), p.2436-2446

2005

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A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Molecular nutrition & food research, 2020-11, Vol.64 (21), p.e2000403-n/a

2020

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Stability to thermal treatment of dipeptidyl peptidase‐IV inhibitory activity of a boarfish (Capros aper) protein hydrolysate when incorporated into tomato‐based products

International journal of food science & technology, 2021-01, Vol.56 (1), p.158-165

2021

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Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties

Journal of functional foods, 2018-01, Vol.40, p.137-145

2018

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Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein

Biochimica et biophysica acta, 2014-06, Vol.1843 (6), p.1123-1134

2014

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Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1

European journal of pharmacology, 2006-10, Vol.547 (1), p.192-199

2006

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(pGlu-Gln)-CCK-8[mPEG]: A novel, long-acting, mini-PEGylated cholecystokinin (CCK) agonist that improves metabolic status in dietary-induced diabetes

Biochimica et biophysica acta, 2013-08, Vol.1830 (8), p.4009-4016

2013

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Development of novel ligands for peptide GPCRs

Current opinion in pharmacology, 2016-12, Vol.31, p.57-62

2016

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Boarfish (Capros aper) protein hydrolysate has potent insulinotropic and GLP‐1 secretory activity in vitro and acute glucose lowering effects in mice

International journal of food science & technology, 2019-01, Vol.54 (1), p.271-281

2019

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Comparison of stability, cellular, glucose-lowering and appetite supressing effects of oxyntomodulin analogues modified at the N-terminus

European journal of pharmacology, 2014-11, Vol.743, p.69-78

2014

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Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents

Current pharmaceutical design, 2004-11, Vol.10 (29), p.3651

2004

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Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles

Journal of functional foods, 2020-10, Vol.73, p.104101, Article 104101

2020

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Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties

Biochemical pharmacology, 2009-10, Vol.78 (8), p.1008-1016

2009

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Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice

Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides

Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity

Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation

Chronic apelin analogue administration is more effective than established incretin therapies for alleviating metabolic dysfunction in diabetic db/db mice

A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation

Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update

Acylated apelin-13 amide analogues exhibit enzyme resistance and prolonged insulin releasing, glucose lowering and anorexic properties

Metabolic effects of combined glucagon receptor antagonism and glucagon-like peptide-1 receptor agonism in high fat fed mice

Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis

Beneficial long‐term antidiabetic actions of N‐ and C‐terminally modified analogues of apelin‐13 in diet‐induced obese diabetic mice

Chemical Ablation of Gastric Inhibitory Polypeptide Receptor Action by Daily (Pro3)GIP Administration Improves Glucose Tolerance and Ameliorates Insulin Resistance and Abnormalities of Islet Structure in Obesity-Related Diabetes

A Narrative Review of the Anti‐Hyperglycemic and Satiating Effects of Fish Protein Hydrolysates and Their Bioactive Peptides

Stability to thermal treatment of dipeptidyl peptidase‐IV inhibitory activity of a boarfish (Capros aper) protein hydrolysate when incorporated into tomato‐based products

Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties

Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein

Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1

(pGlu-Gln)-CCK-8[mPEG]: A novel, long-acting, mini-PEGylated cholecystokinin (CCK) agonist that improves metabolic status in dietary-induced diabetes

Development of novel ligands for peptide GPCRs

Boarfish (Capros aper) protein hydrolysate has potent insulinotropic and GLP‐1 secretory activity in vitro and acute glucose lowering effects in mice

Comparison of stability, cellular, glucose-lowering and appetite supressing effects of oxyntomodulin analogues modified at the N-terminus

Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents

Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles

Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties

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