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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

mAbs, 2018-02, Vol.10 (2), p.244-255

2018

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Recommendations for the validation of flow cytometric testing during drug development: II assays

Journal of immunological methods, 2011-01, Vol.363 (2), p.120-134

2011

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Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

mAbs, 2016-08, Vol.8 (6), p.1064-1078

2016

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Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

Scientific reports, 2018-03, Vol.8 (1), p.4241-15, Article 4241

2018

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One Mouse, One Pharmacokinetic Profile: Quantitative Whole Blood Serial Sampling for Biotherapeutics

Pharmaceutical research, 2014-07, Vol.31 (7), p.1823-1833

2014

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Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics

The Journal of biological chemistry, 2013-06, Vol.288 (23), p.16529-16537

2013

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Comparison of Succinimidyl [125I]Iodobenzoate with Iodogen Iodination Methods to Study Pharmacokinetics and ADME of Biotherapeutics

Pharmaceutical research, 2014-10, Vol.31 (10), p.2810-2821

2014

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Life cycle management of critical ligand-binding reagents

Bioanalysis, 2013-11, Vol.5 (21), p.2679-2696

2013

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Faster in vivo clearance of human embryonic kidney than Chinese hamster ovary cell derived protein: Role of glycan mediated clearance

Journal of bioscience and bioengineering, 2015-06, Vol.119 (6), p.657-660

2015

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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

mAbs, 2018-01, Vol.10 (1), p.81-94

2018

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Challenges in selectivity, specificity and quantitation range of ligand-binding assays: case studies using a microfluidics platform

Bioanalysis, 2014-04, Vol.6 (8), p.1049-1057

2014

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Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy

International Journal of Molecular Imaging, 2016-01, Vol.2016, p.5768312-11

2016

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Human FcRn Tissue Expression Profile and Half-Life in PBMCs

Biomolecules (Basel, Switzerland), 2019-08, Vol.9 (8), p.373

2019

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Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents

The AAPS journal, 2012-06, Vol.14 (2), p.316-328

2012

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Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice

mAbs, 2016-07, Vol.8 (5), p.848-853

2016

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Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation

British journal of pharmacology, 2017-01, Vol.174 (1), p.70-81

2017

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Quantitative biodistribution of biotherapeutics at whole body, organ and cellular levels by autoradiography

Bioanalysis, 2018-09, Vol.10 (18), p.1487-1500

2018

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Bioanalytical platform comparison using a generic human IgG PK assay format

Journal of immunological methods, 2013-11, Vol.397 (1-2), p.28-36

2013

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Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey

Birth defects research, 2020-01, Vol.112 (1), p.105-117

2020

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Placental transfer of 125iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey

Birth defects research, 2020-01, Vol.112 (1), p.105-117

2020

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Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD

Bioanalysis, 2012-11, Vol.4 (21), p.2589-2604

2012

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Recommendations for the validation of flow cytometric testing during drug development: II assays: Flow Cytometry-based Biomarkers in Translational Medicine and Drug Development

Journal of immunological methods, 2011, Vol.363 (2), p.120-134

2011

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Immunogenicity Testing Using Flow Cytometry

Flow Cytometry in Drug Discovery and Development, 2010, p.205-223

2010

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Placental transfer of 125iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey

Reproductive toxicology (Elmsford, N.Y.), 2014-09, Vol.48, p.30-30

2014

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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

mAbs, 2018, Vol.10 (1), p.81-94

2018

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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics

Recommendations for the validation of flow cytometric testing during drug development: II assays

Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies

Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing

One Mouse, One Pharmacokinetic Profile: Quantitative Whole Blood Serial Sampling for Biotherapeutics

Engineering a Monomeric Fc Domain Modality by N-Glycosylation for the Half-life Extension of Biotherapeutics

Comparison of Succinimidyl [125I]Iodobenzoate with Iodogen Iodination Methods to Study Pharmacokinetics and ADME of Biotherapeutics

Life cycle management of critical ligand-binding reagents

Faster in vivo clearance of human embryonic kidney than Chinese hamster ovary cell derived protein: Role of glycan mediated clearance

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

Challenges in selectivity, specificity and quantitation range of ligand-binding assays: case studies using a microfluidics platform

Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy

Human FcRn Tissue Expression Profile and Half-Life in PBMCs

Ligand Binding Assays in the 21st Century Laboratory: Recommendations for Characterization and Supply of Critical Reagents

Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice

Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation

Quantitative biodistribution of biotherapeutics at whole body, organ and cellular levels by autoradiography

Bioanalytical platform comparison using a generic human IgG PK assay format

Placental transfer of 125 iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey

Placental transfer of 125iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey

Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD

Recommendations for the validation of flow cytometric testing during drug development: II assays: Flow Cytometry-based Biomarkers in Translational Medicine and Drug Development

Immunogenicity Testing Using Flow Cytometry

Placental transfer of 125iodinated humanized immunoglobulin G2Δa in the cynomolgus monkey

Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics

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