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Antimicrobial Properties and Mode of Action of the Pyrrothine Holomycin

Antimicrobial Agents and Chemotherapy, 2001-02, Vol.45 (2), p.532-539

2001

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Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

Antimicrobial Agents and Chemotherapy, 2003-06, Vol.47 (6), p.1784-1789

2003

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The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3171-3174

2002

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Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.1959-1962

2002

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Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase

The Journal of Antibiotics, 2000/11/25, Vol.53(11), pp.1282-1292

2000

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SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4865-4871

2006

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Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.3937-3941

2004

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Thiocarbonyl-based 1,3-dipolarophiles for the synthesis of C(2)-unsubstituted penems

Pure and applied chemistry, 2005-12, Vol.77 (12), p.2033-2040

2005

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Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A

Biochemistry (Easton), 2000-05, Vol.39 (20), p.6003-6011

2000

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S-Alkyl Dithioformates as 1,3-Dipolarophiles. Generation of C(2)-Unsubstituted Penems

Organic letters, 2004-08, Vol.6 (16), p.2781-2783

2004

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Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (18), p.4872-4878

2006

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The Chemistry of Pseudomonic Acid. † 18. Heterocyclic Replacement of the α,β-Unsaturated Ester: Synthesis, Molecular Modeling, and Antibacterial Activity

Journal of medicinal chemistry, 1997-08, Vol.40 (16), p.2563-2570

1997

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Analogues of SB-203207 as inhibitors of tRNA synthetases

Bioorganic & medicinal chemistry letters, 2000-10, Vol.10 (20), p.2263-2266

2000

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Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (4), p.665-668

2003

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Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (9), p.2305-2309

2005

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Seven-Membered Lactams as Constraints for Amide Self-Recognition

Journal of the American Chemical Society, 1995-09, Vol.117 (38), p.9768-9769

1995

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Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1265-1268

2003

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Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383

Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (16), p.1811-1814

2000

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Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (5), p.715-718

2001

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Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (5), p.711-714

2001

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Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207

Bioorganic & medicinal chemistry, 2003-07, Vol.11 (13), p.2687-2694

2003

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Chemistry of Pseudomonic Acid. Part 16: Aryl and Heteroaryl Ketone Derivatives of Monic Acid

The Journal of Antibiotics, 1996/04/25, Vol.49(4), pp.390-394

1996

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Inhibitors of Bacterial Tyrosyl tRNA Synthetase: Synthesis of Carbocyclic Analogues of the Natural Product SB-219383

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (18), p.2499-2502

2001

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The Chemistry of Pseudomonic Acid. 17. Dual-Action C-1 Oxazole Derivatives of Pseudomonic Acid Having an Extended Spectrum of Antibacterial Activity

Journal of medicinal chemistry, 1996-08, Vol.39 (18), p.3596-3600

1996

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Nanomolar Inhibitors of Staphylococcus a ureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.1959-1962

2002

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Antimicrobial Properties and Mode of Action of the Pyrrothine Holomycin

Variable Sensitivity to Bacterial Methionyl-tRNA Synthetase Inhibitors Reveals Subpopulations of Streptococcus pneumoniae with Two Distinct Methionyl-tRNA Synthetase Genes

The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

Synthesis and Activity of Analogues of SB-219383: Novel Potent Inhibitors of Bacterial Tyrosyl tRNA Synthetase

SAR of biphenyl carboxamide ligands of the human melanin-concentrating hormone receptor 1 (MCH R1): Discovery of antagonist SB-568849

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues

Thiocarbonyl-based 1,3-dipolarophiles for the synthesis of C(2)-unsubstituted penems

Rational Design of Femtomolar Inhibitors of Isoleucyl tRNA Synthetase from a Binding Model for Pseudomonic Acid-A

S-Alkyl Dithioformates as 1,3-Dipolarophiles. Generation of C(2)-Unsubstituted Penems

Discovery of potent and stable conformationally constrained analogues of the MCH R1 antagonist SB-568849

The Chemistry of Pseudomonic Acid. † 18. Heterocyclic Replacement of the α,β-Unsaturated Ester: Synthesis, Molecular Modeling, and Antibacterial Activity

Analogues of SB-203207 as inhibitors of tRNA synthetases

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-Positive antibacterial activity

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

Seven-Membered Lactams as Constraints for Amide Self-Recognition

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-Positive antibacterial activity

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383

Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase

Synthesis and activity of analogues of the isoleucyl tRNA synthetase inhibitor SB-203207

Chemistry of Pseudomonic Acid. Part 16: Aryl and Heteroaryl Ketone Derivatives of Monic Acid

Inhibitors of Bacterial Tyrosyl tRNA Synthetase: Synthesis of Carbocyclic Analogues of the Natural Product SB-219383

The Chemistry of Pseudomonic Acid. 17. Dual-Action C-1 Oxazole Derivatives of Pseudomonic Acid Having an Extended Spectrum of Antibacterial Activity

Nanomolar Inhibitors of Staphylococcus a ureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens

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