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G-Protein-coupled receptor oligomerization and its potential for drug discovery

Nature reviews. Drug discovery, 2002-10, Vol.1 (10), p.808-820

2002

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Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal

The Journal of biological chemistry, 2004-08, Vol.279 (34), p.35671-35678

2004

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Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity

Trends in pharmacological sciences (Regular ed.), 2006-04, Vol.27 (4), p.190-194

2006

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Modification of the Terminal Residue of Apelin-13 Antagonizes Its Hypotensive Action

Endocrinology (Philadelphia), 2005-01, Vol.146 (1), p.231-236

2005

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Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties

The Journal of biological chemistry, 2000-08, Vol.275 (34), p.26128-26135

2000

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Characterization of Apelin, the Ligand for the APJ Receptor

Journal of neurochemistry, 2000-01, Vol.74 (1), p.34-41

2000

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Agonists at the δ‐opioid receptor modify the binding of µ‐receptor agonists to the µ–δ receptor hetero‐oligomer

British journal of pharmacology, 2010-11, Vol.161 (5), p.1122-1136

2010

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A Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of μ and δ Opioid Receptor Hetero-oligomers

The Journal of biological chemistry, 2005-11, Vol.280 (46), p.38478-38488

2005

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Characterization of the Human Cysteinyl Leukotriene 2 Receptor

The Journal of biological chemistry, 2000-09, Vol.275 (39), p.30531-30536

2000

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Discovery of a Novel Member of the Histamine Receptor Family

Molecular pharmacology, 2001-03, Vol.59 (3), p.427-433

2001

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Characterization of a Family of Endogenous Neuropeptide Ligands for the G Protein-Coupled Receptors GPR7 and GPR8

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (10), p.6251-6256

2003

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D2 Dopamine Receptor Homodimerization Is Mediated by Multiple Sites of Interaction, Including an Intermolecular Interaction Involving Transmembrane Domain 4

Biochemistry (Easton), 2003-09, Vol.42 (37), p.11023-11031

2003

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Discovery of a receptor related to the galanin receptors

FEBS letters, 1999-03, Vol.446 (1), p.103-107

1999

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Homo- and hetero-oligomerization of G protein-coupled receptors

Life sciences (1973), 2003-12, Vol.74 (2), p.173-180

2003

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D1 and D2 Dopamine Receptors Form Heterooligomers and Cointernalize after Selective Activation of Either Receptor

Molecular pharmacology, 2005-09, Vol.68 (3), p.568-578

2005

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Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

The Journal of biological chemistry, 2000-05, Vol.275 (19), p.14281-14286

2000

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Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation

The Journal of cell biology, 2001-04, Vol.153 (2), p.429-434

2001

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Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation

The European journal of neuroscience, 2005-10, Vol.22 (7), p.1741-1750

2005

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Discovery and mapping of ten novel G protein-coupled receptor genes

Gene, 2001-09, Vol.275 (1), p.83-91

2001

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Oligomerization of opioid receptors: generation of novel signaling units

Current Opinion in Pharmacology, 2002-02, Vol.2 (1), p.76-81

2002

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Dopamine Receptor Oligomerization Visualized in Living Cells

The Journal of biological chemistry, 2005-11, Vol.280 (44), p.37225-37235

2005

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Molecular Cloning and Characterization of a Lysophosphatidic Acid Receptor, Edg-7, Expressed in Prostate

Molecular pharmacology, 2000-04, Vol.57 (4), p.753-759

2000

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Discovery of Three Novel G-Protein-Coupled Receptor Genes

Genomics (San Diego, Calif.), 1998-01, Vol.47 (2), p.310-313

1998

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Inhibition of Cell Surface Expression by Mutant Receptors Demonstrates that D2 Dopamine Receptors Exist as Oligomers in the Cell

Molecular pharmacology, 2000-07, Vol.58 (1), p.120-128

2000

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Minireview: Diversity and Complexity of Signaling through Peptidergic G Protein-Coupled Receptors

Endocrinology (Philadelphia), 2004-06, Vol.145 (6), p.2645-2652

2004

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G-Protein-coupled receptor oligomerization and its potential for drug discovery

Dopamine D1 and D2 Receptor Co-activation Generates a Novel Phospholipase C-mediated Calcium Signal

Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity

Modification of the Terminal Residue of Apelin-13 Antagonizes Its Hypotensive Action

Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties

Characterization of Apelin, the Ligand for the APJ Receptor

Agonists at the δ‐opioid receptor modify the binding of µ‐receptor agonists to the µ–δ receptor hetero‐oligomer

A Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of μ and δ Opioid Receptor Hetero-oligomers

Characterization of the Human Cysteinyl Leukotriene 2 Receptor

Discovery of a Novel Member of the Histamine Receptor Family

Characterization of a Family of Endogenous Neuropeptide Ligands for the G Protein-Coupled Receptors GPR7 and GPR8

D2 Dopamine Receptor Homodimerization Is Mediated by Multiple Sites of Interaction, Including an Intermolecular Interaction Involving Transmembrane Domain 4

Discovery of a receptor related to the galanin receptors

Homo- and hetero-oligomerization of G protein-coupled receptors

D1 and D2 Dopamine Receptors Form Heterooligomers and Cointernalize after Selective Activation of Either Receptor

Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8

Identification of a Molecular Target of Psychosine and Its Role in Globoid Cell Formation

Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation

Discovery and mapping of ten novel G protein-coupled receptor genes

Oligomerization of opioid receptors: generation of novel signaling units

Dopamine Receptor Oligomerization Visualized in Living Cells

Molecular Cloning and Characterization of a Lysophosphatidic Acid Receptor, Edg-7, Expressed in Prostate

Discovery of Three Novel G-Protein-Coupled Receptor Genes

Inhibition of Cell Surface Expression by Mutant Receptors Demonstrates that D2 Dopamine Receptors Exist as Oligomers in the Cell

Minireview: Diversity and Complexity of Signaling through Peptidergic G Protein-Coupled Receptors

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