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Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells

The Journal of biological chemistry, 2017-10, Vol.292 (41), p.16983-16998

2017

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FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion

Oncogene, 2018-06, Vol.37 (23), p.3131-3150

2018

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PDLIM2 is highly expressed in Breast Cancer tumour-associated macrophages and is required for M2 macrophage polarization

Frontiers in oncology, 2022-11, Vol.12, p.1028959-1028959

2022

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Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

Journal of neurochemistry, 2005-04, Vol.93 (1), p.105-117

2005

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Controlled Signaling-Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments

Frontiers in endocrinology (Lausanne), 2021-01, Vol.11, p.620013-620013

2021

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IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance

Frontiers in endocrinology (Lausanne), 2015-07, Vol.6, p.106-106

2015

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Essential Function for PDLIM2 in Cell Polarization in Three-Dimensional Cultures by Feedback Regulation of the β1-Integrin–RhoA Signaling Axis

Neoplasia (New York, N.Y.), 2014-05, Vol.16 (5), p.422-431

2014

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Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase

The Journal of biological chemistry, 2009-07, Vol.284 (30), p.20263-20274

2009

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IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

Oncotarget, 2016-08, Vol.7 (35), p.56826-56841

2016

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Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and β1 Integrin To Promote Cell Migration

Molecular and Cellular Biology, 2006-06, Vol.26 (11), p.4041-4051

2006

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Tyrosine 302 in RACK1 Is Essential for Insulin-like Growth Factor-I-mediated Competitive Binding of PP2A and β1 Integrin and for Tumor Cell Proliferation and Migration

The Journal of biological chemistry, 2008-08, Vol.283 (34), p.22952-22961

2008

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RACK(1) to the future – a historical perspective

Cell communication and signaling, 2013-08, Vol.11 (1), p.53-53, Article 53

2013

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Serine Phosphorylation of the Insulin-like Growth Factor I (IGF-1) Receptor C-terminal Tail Restrains Kinase Activity and Cell Growth

The Journal of biological chemistry, 2012-08, Vol.287 (33), p.28180-28194

2012

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Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking

The Journal of biological chemistry, 2010-01, Vol.285 (1), p.381-391

2010

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IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway

Cells (Basel, Switzerland), 2020-01, Vol.9 (1), p.147

2020

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Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

Neurobiology of aging, 2010-02, Vol.31 (2), p.224-243

2010

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RACK1 Is an Insulin-like Growth Factor 1 (IGF-1) Receptor-interacting Protein That Can Regulate IGF-1-mediated Akt Activation and Protection from Cell Death

The Journal of biological chemistry, 2002-06, Vol.277 (25), p.22581-22589

2002

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Making the Executive ‘Function’ for the Foundations of Mathematics: the Need for Explicit Theories of Change for Early Interventions

Educational psychology review, 2023-12, Vol.35 (4), p.110, Article 110

2023

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Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1

PLoS genetics, 2013-04, Vol.9 (4), p.e1003310-e1003310

2013

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RACK1-mediated Integration of Adhesion and Insulin-like Growth Factor I (IGF-I) Signaling and Cell Migration Are Defective in Cells Expressing an IGF-I Receptor Mutated at Tyrosines 1250 and 1251

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.7624-7633

2005

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Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

BMC cancer, 2008-07, Vol.8 (1), p.187-187, Article 187

2008

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The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration

Journal of cellular biochemistry, 2008-12, Vol.105 (5), p.1250-1259

2008

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Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation

Adipocyte, 2017-10, Vol.6 (4), p.259-276

2017

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Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts

Molecular and Cellular Biology, 2002-04, Vol.22 (7), p.1998-2010

2002

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Induction of apoptosis by the Bcl-2 homologue Bak

Nature (London), 1995-04, Vol.374 (6524), p.733-736

1995

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Insulin-like growth factor 1 signaling is essential for mitochondrial biogenesis and mitophagy in cancer cells

FES-related tyrosine kinase activates the insulin-like growth factor-1 receptor at sites of cell adhesion

PDLIM2 is highly expressed in Breast Cancer tumour-associated macrophages and is required for M2 macrophage polarization

Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer's disease pathology

Controlled Signaling-Insulin-Like Growth Factor Receptor Endocytosis and Presence at Intracellular Compartments

IGF-1 Receptor and Adhesion Signaling: An Important Axis in Determining Cancer Cell Phenotype and Therapy Resistance

Essential Function for PDLIM2 in Cell Polarization in Three-Dimensional Cultures by Feedback Regulation of the β1-Integrin–RhoA Signaling Axis

Phosphorylation of RACK1 on Tyrosine 52 by c-Abl Is Required for Insulin-like Growth Factor I-mediated Regulation of Focal Adhesion Kinase

IGF-1R inhibition sensitizes breast cancer cells to ATM-related kinase (ATR) inhibitor and cisplatin

Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and β1 Integrin To Promote Cell Migration

Tyrosine 302 in RACK1 Is Essential for Insulin-like Growth Factor-I-mediated Competitive Binding of PP2A and β1 Integrin and for Tumor Cell Proliferation and Migration

RACK(1) to the future – a historical perspective

Serine Phosphorylation of the Insulin-like Growth Factor I (IGF-1) Receptor C-terminal Tail Restrains Kinase Activity and Cell Growth

Heme-binding Protein HRG-1 Is Induced by Insulin-like Growth Factor I and Associates with the Vacuolar H+-ATPase to Control Endosomal pH and Receptor Trafficking

IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

RACK1 Is an Insulin-like Growth Factor 1 (IGF-1) Receptor-interacting Protein That Can Regulate IGF-1-mediated Akt Activation and Protection from Cell Death

Making the Executive ‘Function’ for the Foundations of Mathematics: the Need for Explicit Theories of Change for Early Interventions

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1

RACK1-mediated Integration of Adhesion and Insulin-like Growth Factor I (IGF-I) Signaling and Cell Migration Are Defective in Cells Expressing an IGF-I Receptor Mutated at Tyrosines 1250 and 1251

Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level

The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration

Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation

Regulation of Insulin-Like Growth Factor Type I (IGF-I) Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and Motility in PTP-1B-Deficient Fibroblasts

Induction of apoptosis by the Bcl-2 homologue Bak

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