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Variability in donor leukocyte counts confound the use of common RNA sequencing data normalization strategies in transcriptomic biomarker studies performed with whole blood

Scientific reports, 2023-09, Vol.13 (1), p.15514-15514, Article 15514

O’Connell, Grant C.

2023

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Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers

Brain injury, 2020-06, Vol.34 (7), p.965-974

2020

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Dataset including whole blood gene expression profiles and matched leukocyte counts with utility for benchmarking cellular deconvolution pipelines

BMC genomic data, 2024-05, Vol.25 (1), p.45-45, Article 45

O'Connell, Grant C

2024

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Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke

Scientific reports, 2017-10, Vol.7 (1), p.12940-14, Article 12940

2017

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Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption

Scientific reports, 2017-04, Vol.7 (1), p.1172-13, Article 1172

2017

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Use of high-sensitivity digital ELISA improves the diagnostic performance of circulating brain-specific proteins for detection of traumatic brain injury during triage

Neurological research (New York), 2020-04, Vol.42 (4), p.346-353

2020

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Diagnosis of ischemic stroke using circulating levels of brain-specific proteins measured via high-sensitivity digital ELISA

Brain research, 2020-07, Vol.1739, p.146861-146861, Article 146861

2020

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High-Throughput Profiling of Circulating Antibody Signatures for Stroke Diagnosis Using Small Volumes of Whole Blood

Neurotherapeutics, 2019-07, Vol.16 (3), p.868-877

2019

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Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage

Proceedings of the National Academy of Sciences - PNAS, 2020-08, Vol.117 (34), p.20764-20775

2020

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Circulating extracellular DNA levels are acutely elevated in ischaemic stroke and associated with innate immune system activation

Brain injury, 2017-08, Vol.31 (10), p.1369-1375

2017

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High-throughput profiling of the circulating proteome suggests sexually dimorphic corticosteroid signaling following ischemic stroke

Physiological genomics, 2018-10, Vol.50 (10), p.876-883

2018

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Shifts in Leukocyte Counts Drive the Differential Expression of Transcriptional Stroke Biomarkers in Whole Blood

Translational stroke research, 2019-02, Vol.10 (1), p.26-35

2019

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Donor white blood cell differential is the single largest determinant of whole blood gene expression patterns

Genomics (San Diego, Calif.), 2023-11, Vol.115 (6), p.110708, Article 110708

2023

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Loss of Adipocyte VEGF Impairs Endurance Exercise Capacity in Mice

Medicine and science in sports and exercise, 2015-11, Vol.47 (11), p.2329-2339

2015

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High Interspecimen Variability in Nucleic Acid Extraction Efficiency Necessitates the Use of Spike-In Control for Accurate qPCR-based Measurement of Plasma Cell-Free DNA Levels

Laboratory medicine, 2017-11, Vol.48 (4), p.332-338

2017

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Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population

Genomics data, 2017-12, Vol.14 (C), p.47-52

2017

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The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity

Translational stroke research, 2016-04, Vol.7 (2), p.103-110

2016

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Analysis of early stroke-induced changes in circulating leukocyte counts using transcriptomic deconvolution

Translational neuroscience, 2018-01, Vol.9 (1), p.161-166

2018

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Optimized methodology for product recovery following emulsion PCR: applications for amplification of aptamer libraries and other complex templates

Journal of biological methods, 2020-03, Vol.7 (1), p.e128-e128

2020

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Machine-learning approach identifies a pattern of gene expression in peripheral blood that can accurately detect ischaemic stroke

Npj genomic medicine, 2016-11, Vol.1 (1), p.16038-16038, Article 16038

2016

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Brain Expression Levels of Commonly Measured Blood Biomarkers of Neurological Damage Differ with Respect to Sex, Race, and Age

Neuroscience, 2024-07, Vol.551, p.79-93

2024

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Newly-identified blood biomarkers of neurological damage are correlated with infarct volume in patients with acute ischemic stroke

Journal of clinical neuroscience, 2021-12, Vol.94, p.107-113

2021

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Interleukin-15 directly stimulates pro-oxidative gene expression in skeletal muscle in-vitro via a mechanism that requires interleukin-15 receptor alpha

Biochemical and biophysical research communications, 2015-03, Vol.458 (3), p.614-619

2015

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Neuro biomarker levels measured with high-sensitivity digital ELISA differ between serum and plasma

Bioanalysis, 2019-11, Vol.11 (22), p.2087-2094

2019

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Use of deep artificial neural networks to identify stroke during triage via subtle changes in circulating cell counts

BMC neurology, 2022-06, Vol.22 (1), p.206-206, Article 206

2022

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Variability in donor leukocyte counts confound the use of common RNA sequencing data normalization strategies in transcriptomic biomarker studies performed with whole blood

Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers

Dataset including whole blood gene expression profiles and matched leukocyte counts with utility for benchmarking cellular deconvolution pipelines

Monocyte-lymphocyte cross-communication via soluble CD163 directly links innate immune system activation and adaptive immune system suppression following ischemic stroke

Peripheral blood AKAP7 expression as an early marker for lymphocyte-mediated post-stroke blood brain barrier disruption

Use of high-sensitivity digital ELISA improves the diagnostic performance of circulating brain-specific proteins for detection of traumatic brain injury during triage

Diagnosis of ischemic stroke using circulating levels of brain-specific proteins measured via high-sensitivity digital ELISA

High-Throughput Profiling of Circulating Antibody Signatures for Stroke Diagnosis Using Small Volumes of Whole Blood

Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage

Circulating extracellular DNA levels are acutely elevated in ischaemic stroke and associated with innate immune system activation

High-throughput profiling of the circulating proteome suggests sexually dimorphic corticosteroid signaling following ischemic stroke

Shifts in Leukocyte Counts Drive the Differential Expression of Transcriptional Stroke Biomarkers in Whole Blood

Donor white blood cell differential is the single largest determinant of whole blood gene expression patterns

Loss of Adipocyte VEGF Impairs Endurance Exercise Capacity in Mice

High Interspecimen Variability in Nucleic Acid Extraction Efficiency Necessitates the Use of Spike-In Control for Accurate qPCR-based Measurement of Plasma Cell-Free DNA Levels

Stroke-associated pattern of gene expression previously identified by machine-learning is diagnostically robust in an independent patient population

The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity

Analysis of early stroke-induced changes in circulating leukocyte counts using transcriptomic deconvolution

Optimized methodology for product recovery following emulsion PCR: applications for amplification of aptamer libraries and other complex templates

Machine-learning approach identifies a pattern of gene expression in peripheral blood that can accurately detect ischaemic stroke

Brain Expression Levels of Commonly Measured Blood Biomarkers of Neurological Damage Differ with Respect to Sex, Race, and Age

Newly-identified blood biomarkers of neurological damage are correlated with infarct volume in patients with acute ischemic stroke

Interleukin-15 directly stimulates pro-oxidative gene expression in skeletal muscle in-vitro via a mechanism that requires interleukin-15 receptor alpha

Neuro biomarker levels measured with high-sensitivity digital ELISA differ between serum and plasma

Use of deep artificial neural networks to identify stroke during triage via subtle changes in circulating cell counts

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