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Glucose-6-phosphatase Catalytic Subunit Gene Family

The Journal of biological chemistry, 2009-10, Vol.284 (43), p.29241-29245

2009

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Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model

Bioscience reports, 2024-01, Vol.44 (1), p.1

2024

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Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

Biochemical journal, 2009-07, Vol.421 (3), p.371-376

2009

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Chronic Glucocorticoid Exposure Induced an S1PR2-RORγ Axis to Enhance Hepatic Gluconeogenesis in Male Mice

Diabetes (New York, N.Y.), 2023-11, Vol.72 (11), p.1534-1546

2023

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G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity

Journal of molecular endocrinology, 2023-11, Vol.71 (4)

2023

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Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose

The Journal of biological chemistry, 2022-02, Vol.298 (2), p.101534-101534, Article 101534

2022

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Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose

Current diabetes reports, 2013-12, Vol.13 (6), p.768-777

O’Brien, Richard M.

2013

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An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets

Diabetes (New York, N.Y.), 2023-11, Vol.72 (11), p.1621-1628

2023

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Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression

PloS one, 2016-09, Vol.11 (9), p.e0162439

2016

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Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species

Journal of molecular evolution, 2019-07, Vol.87 (4-6), p.147-151

2019

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The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content

Journal of molecular evolution, 2018-12, Vol.86 (9), p.613-617

2018

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Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter

Journal of structural biology, 2017-04, Vol.198 (1), p.54-64

2017

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Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion

Endocrinology (Philadelphia), 2016-12, Vol.157 (12), p.4534-4541

2016

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Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion

JCI insight, 2017-03, Vol.2 (6), p.e91863-e91863

2017

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Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model

PNAS nexus, 2024-02, Vol.3 (2), p.pgae036-pgae036

2024

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Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets

Diabetes (New York, N.Y.), 2015-06, Vol.64 (6), p.2129-2137

2015

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Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

Molecular metabolism (Germany), 2022-12, Vol.66, p.101632, Article 101632

2022

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G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance

Endocrinology (Philadelphia), 2016-11, Vol.157 (11), p.4133-4145

2016

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G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting

Molecular metabolism (Germany), 2020-11, Vol.41, p.101043-101043, Article 101043

2020

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Zinc transporter 8 (ZnT8) and β cell function

Trends in endocrinology and metabolism, 2014-08, Vol.25 (8), p.415-424

2014

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The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer

Biochemical journal, 2011-01, Vol.433 (1), p.95-105

2011

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Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1

The Journal of biological chemistry, 2022-01, Vol.298 (1), p.101520-101520, Article 101520

2022

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Characterizing the Phospholipid Profiles in Mammalian Tissues by MALDI FTMS

Analytical chemistry (Washington), 2006-05, Vol.78 (9), p.3062-3071

2006

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Multiple promoter and enhancer differences likely contribute to augmented G6PC2 expression in human versus mouse pancreatic islet alpha cells

Journal of molecular endocrinology, 2024-10, Vol.73 (3)

2024

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Biochemical and metabolic characterization of a G6PC2 inhibitor

Biochimie, 2024-07, Vol.222, p.109-122

2024

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Glucose-6-phosphatase Catalytic Subunit Gene Family

Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model

Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretion

Chronic Glucocorticoid Exposure Induced an S1PR2-RORγ Axis to Enhance Hepatic Gluconeogenesis in Male Mice

G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity

Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose

Moving on from GWAS: Functional Studies on the G6PC2 Gene Implicated in the Regulation of Fasting Blood Glucose

An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets

Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression

Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species

The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content

Crystal structures reveal a new and novel FoxO1 binding site within the human glucose-6-phosphatase catalytic subunit 1 gene promoter

Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion

Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion

Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model

Novel stable isotope analyses demonstrate significant rates of glucose cycling in mouse pancreatic islets

Zinc transporter 8 haploinsufficiency protects against beta cell dysfunction in type 1 diabetes by increasing mitochondrial respiration

G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance

G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting

Zinc transporter 8 (ZnT8) and β cell function

The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer

Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1

Characterizing the Phospholipid Profiles in Mammalian Tissues by MALDI FTMS

Multiple promoter and enhancer differences likely contribute to augmented G6PC2 expression in human versus mouse pancreatic islet alpha cells

Biochemical and metabolic characterization of a G6PC2 inhibitor

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