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Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis

mAbs, 2023, Vol.15 (1), p.2209920

2023

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Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk

PloS one, 2023-09, Vol.18 (9), p.e0291330

2023

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A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties

PloS one, 2016-12, Vol.11 (12), p.e0167935-e0167935

2016

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Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells

Cellular & molecular immunology, 2016-05, Vol.13 (3), p.391-400

2016

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Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

Neurobiology of disease, 2002-02, Vol.9 (1), p.11-23

2002

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C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

Journal of neurochemistry, 2006-01, Vol.96 (1), p.218-227

2006

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Pegloticase co-administered with high MW polyethylene glycol effectively reduces PEG-immunogenicity and restores prolonged circulation in mouse

Acta biomaterialia, 2023-10, Vol.170, p.250-259

2023

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Flavodoxin Hydroquinone Reduces Azotobacter vinelandii Fe Protein to the All-Ferrous Redox State with a S = 0 Spin State

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (46), p.17131-17136

2006

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Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

The FASEB journal, 2006-08, Vol.20 (10), p.1671-1679

2006

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High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies

Journal of controlled release, 2021-10, Vol.338, p.804-812

2021

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Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates

Molecular neurodegeneration, 2006-06, Vol.1 (1), p.3-3, Article 3

2006

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A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin

The Journal of biological chemistry, 2004-10, Vol.279 (41), p.43148-43156

2004

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A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells

The Journal of biological chemistry, 2018-01, Vol.293 (3), p.941-952

2018

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Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface

The Journal of biological chemistry, 2017-09, Vol.292 (35), p.14401-14412

2017

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Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy

Biochemical and biophysical research communications, 2006-02, Vol.340 (2), p.668-674

2006

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Signal Peptide Peptidase: Biochemical Properties and Modulation by Nonsteroidal Antiinflammatory Drugs

Biochemistry (Easton), 2006-07, Vol.45 (28), p.8649-8656

2006

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Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells

Molecular neurodegeneration, 2006-11, Vol.1 (1), p.16-16, Article 16

2006

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Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor

The Journal of biological chemistry, 2004-04, Vol.279 (15), p.15153-15160

2004

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In vivo and ex vivo imaging of amyloid-β cascade aggregates with a Pronucleon™ peptide

Journal of Alzheimer's disease, 2013-01, Vol.34 (4), p.957-967

2013

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Targeting the junction of CɛmX and ɛ-migis for the specific depletion of mIgE-expressing B cells

Molecular immunology, 2012-10, Vol.52 (3-4), p.279-288

2012

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Overexpression of nicastrin increases Abeta production

The FASEB journal, 2003-06, Vol.17 (9), p.1138-1140

2003

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Enhanced Efficiency of ATP Hydrolysis during Nitrogenase Catalysis Utilizing Reductants That Form the All-Ferrous Redox State of the Fe Protein

Biochemistry (Easton), 1999-10, Vol.38 (43), p.14279-14285

1999

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Evidence for a Two-Electron Transfer Using the All-Ferrous Fe Protein during Nitrogenase Catalysis

The Journal of biological chemistry, 2000-12, Vol.275 (50), p.39307-39312

2000

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Evidence for a synergistic salt–protein interaction—complex patterns of activation vs. inhibition of nitrogenase by salt

Biophysical chemistry, 2006-08, Vol.122 (3), p.184-194

2006

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1954. A Randomized Study to Evaluate the Shedding and Immunogenicity of H1N1 Strains in Trivalent and Quadrivalent Formulations of FluMist in Children 24 to <48 Months of Age

Open forum infectious diseases, 2018-11, Vol.5 (suppl_1), p.S564-S565

2018

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Izokibep: Preclinical development and first-in-human study of a novel IL-17A neutralizing Affibody molecule in patients with plaque psoriasis

Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk

A Therapeutic Uricase with Reduced Immunogenicity Risk and Improved Development Properties

Development of an antibody that neutralizes soluble IgE and eliminates IgE expressing B cells

Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

C‐terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

Pegloticase co-administered with high MW polyethylene glycol effectively reduces PEG-immunogenicity and restores prolonged circulation in mouse

Flavodoxin Hydroquinone Reduces Azotobacter vinelandii Fe Protein to the All-Ferrous Redox State with a S = 0 Spin State

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

High MW polyethylene glycol prolongs circulation of pegloticase in mice with anti-PEG antibodies

Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates

A Signal Peptide Peptidase (SPP) Reporter Activity Assay Based on the Cleavage of Type II Membrane Protein Substrates Provides Further Evidence for an Inverted Orientation of the SPP Active Site Relative to Presenilin

A neutralizing antibody that blocks delivery of the enzymatic cargo of Clostridium difficile toxin TcdB into host cells

Use of a neutralizing antibody helps identify structural features critical for binding of Clostridium difficile toxin TcdA to the host cell surface

Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy

Signal Peptide Peptidase: Biochemical Properties and Modulation by Nonsteroidal Antiinflammatory Drugs

Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells

Signal Peptide Peptidase Forms a Homodimer That Is Labeled by an Active Site-directed γ-Secretase Inhibitor

In vivo and ex vivo imaging of amyloid-β cascade aggregates with a Pronucleon™ peptide

Targeting the junction of CɛmX and ɛ-migis for the specific depletion of mIgE-expressing B cells

Overexpression of nicastrin increases Abeta production

Enhanced Efficiency of ATP Hydrolysis during Nitrogenase Catalysis Utilizing Reductants That Form the All-Ferrous Redox State of the Fe Protein

Evidence for a Two-Electron Transfer Using the All-Ferrous Fe Protein during Nitrogenase Catalysis

Evidence for a synergistic salt–protein interaction—complex patterns of activation vs. inhibition of nitrogenase by salt

1954. A Randomized Study to Evaluate the Shedding and Immunogenicity of H1N1 Strains in Trivalent and Quadrivalent Formulations of FluMist in Children 24 to <48 Months of Age

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