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Peptide Antiviral Strategies as an Alternative to Treat Lower Respiratory Viral Infections

Frontiers in immunology, 2019-06, Vol.10, p.1366-1366

Nyanguile, Origène

2019

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Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1880-1892

2014

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Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase

Journal of medicinal chemistry, 2009-07, Vol.52 (14), p.4099-4102

2009

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Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

Journal of Virology, 2007-07, Vol.81 (13), p.6909-6919

2007

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1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus

Journal of Virology, 2010-03, Vol.84 (6), p.2923-2934

2010

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1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors

Antimicrobial Agents and Chemotherapy, 2008-12, Vol.52 (12), p.4420-4431

2008

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A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading

Antimicrobial agents and chemotherapy, 2017-04, Vol.61 (4)

2017

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Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release

Chemical science (Cambridge), 2024-01, Vol.15 (4), p.1324-1337

2024

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Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF

Science (American Association for the Advancement of Science), 1997-08, Vol.277 (5330), p.1310-1313

1997

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Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice

Antimicrobial agents and chemotherapy, 2020-09, Vol.64 (10)

2020

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Template directed synthesis of antibody Fc conjugates with concomitant ligand release

Chemical science (Cambridge), 2022-04, Vol.13 (14), p.3965-3976

2022

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TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

Antimicrobial Agents and Chemotherapy, 2012-09, Vol.56 (9), p.4676-4684

2012

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Targeting the Respiratory Syncytial Virus N0-P Complex with Constrained α-Helical Peptides in Cells and Mice

Antimicrobial agents and chemotherapy, 2020-09, Vol.64 (10)

2020

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Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4437-4443

2012

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Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Angewandte Chemie (International ed.), 2012-05, Vol.51 (19), p.4637-4640

2012

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Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors

Gastroenterology (New York, N.Y. 1943), 2008-11, Vol.135 (5), p.1710-1718.e2

2008

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1,5-Benzodiazepine inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2492-2496

2009

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Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4431-4436

2012

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A Versatile Framework for the Design of Ligand-Dependent, Transgene-Specific Transcription Factors

Molecular therapy, 2001-02, Vol.3 (2), p.262-273

2001

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Bisphosphonate-Mediated Gene Vector Delivery from the Metal Surfaces of Stents

Proceedings of the National Academy of Sciences - PNAS, 2006-01, Vol.103 (1), p.159-164

2006

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A Nonnatural Transcriptional Coactivator

Proceedings of the National Academy of Sciences - PNAS, 1997-12, Vol.94 (25), p.13402-13406

1997

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Abstract 1304: AbYlinkTM: A site-selective labeling method for preclinical imaging of therapeutic antibodies

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1304-1304

2021

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Structure-Based Macrocyclization Yields HepatitisC Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Angewandte Chemie (International ed.), 2012-05, Vol.51 (19), p.4637

International ed. in English, 2012

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Structure-Based Macrocyclization Yields HepatitisC Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Angewandte Chemie, 2012-05, Vol.124 (19), p.4715

2012

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Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Angewandte Chemie, 2012-05, Vol.124 (19), p.4715-4718

2012

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Peptide Antiviral Strategies as an Alternative to Treat Lower Respiratory Viral Infections

Discovery and Early Development of TMC647055, a Non-Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase

Binding-Site Identification and Genotypic Profiling of Hepatitis C Virus Polymerase Inhibitors

1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus

1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors

A Short Double-Stapled Peptide Inhibits Respiratory Syncytial Virus Entry and Spreading

Site-selective template-directed synthesis of antibody Fc conjugates with concomitant ligand release

Induced α Helix in the VP16 Activation Domain upon Binding to a Human TAF

Targeting the Respiratory Syncytial Virus N 0 -P Complex with Constrained α-Helical Peptides in Cells and Mice

Template directed synthesis of antibody Fc conjugates with concomitant ligand release

TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

Targeting the Respiratory Syncytial Virus N0-P Complex with Constrained α-Helical Peptides in Cells and Mice

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Antiviral Suppression vs Restoration of RIG-I Signaling by Hepatitis C Protease and Polymerase Inhibitors

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series

A Versatile Framework for the Design of Ligand-Dependent, Transgene-Specific Transcription Factors

Bisphosphonate-Mediated Gene Vector Delivery from the Metal Surfaces of Stents

A Nonnatural Transcriptional Coactivator

Abstract 1304: AbYlinkTM: A site-selective labeling method for preclinical imaging of therapeutic antibodies

Structure-Based Macrocyclization Yields HepatitisC Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Structure-Based Macrocyclization Yields HepatitisC Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

Structure-Based Macrocyclization Yields Hepatitis C Virus NS5B Inhibitors with Improved Binding Affinities and Pharmacokinetic Properties

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