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Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?

Bone (New York, N.Y.), 2000-08, Vol.27 (2), p.177-184

2000

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Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro

Bone (New York, N.Y.), 2001-05, Vol.28 (5), p.465-473

2001

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Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7

Journal of medicinal chemistry, 2001-06, Vol.44 (12), p.2015-2026

2001

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Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders

Journal of bone and mineral research, 1998-03, Vol.13 (3), p.371-382

1998

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Injurious Mechanical Compression of Bovine Articular Cartilage Induces Chondrocyte Apoptosis

Archives of biochemistry and biophysics, 2000-09, Vol.381 (2), p.205-212

2000

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Selective inhibitors of apoptotic caspases: implications for novel therapeutic strategies

Drug Discovery Today, 2001-01, Vol.6 (2), p.85-91

2001

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Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

The EMBO journal, 2001-06, Vol.20 (12), p.3101-3113

2001

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Differential expression of Egr-1 in osteoarthritic compared to normal adult human articular cartilage

Osteoarthritis and cartilage, 2000-05, Vol.8 (3), p.161-169

2000

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Human osteoclastoma‐derived stromal cells: Correlation of the ability to form mineralized nodules in vitro with formation of bone in vivo

Journal of bone and mineral research, 1996-10, Vol.11 (10), p.1453-1460

1996

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The selective oestrogen receptor modulators idoxifene and raloxifene have fundamentally different cell-specific oestrogen-response element (ERE)-dependent/independent mechanisms in vitro

European journal of cancer (1990), 2000-09, Vol.36, p.63-64

2000

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Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents

Cancer chemotherapy and pharmacology, 2001-05, Vol.47 (5), p.437-443

2001

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Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro

Journal of orthopaedic research, 2000-05, Vol.18 (3), p.356-363

2000

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Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications

Current opinion in pharmacology, 2004-06, Vol.4 (3), p.290-294

2004

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Playing with bone and fat

Journal of cellular biochemistry, 2006-05, Vol.98 (2), p.251-266

2006

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Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions

The Journal of biological chemistry, 1999-06, Vol.274 (24), p.17123-17131

1999

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Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats

Endocrinology (Philadelphia), 1998-12, Vol.139 (12), p.5224-5234

1998

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Expression of a human gene for polyamine transport in Chinese-hamster ovary cells

Biochemical journal, 1989-11, Vol.263 (3), p.745-752

1989

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Therapeutic potential of oestrogen receptor ligands in development for osteoporosis

Emerging drugs, 2001-04, Vol.6 (1), p.137-154

2001

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Drug Discovery and Target Validation

Cells, tissues, organs, 2001-01, Vol.169 (3), p.265-271

Nuttall, Mark E.

2001

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Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells

Bone (New York, N.Y.), 2006-12, Vol.39 (6), p.1361-1372

2006

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Role of caspases in human renal proximal tubular epithelial cell apoptosis

European journal of pharmacology, 2001-12, Vol.433 (2), p.135-140

2001

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Acetylation of spermidine and methylglyoxal bis(guanylhydrazone) in baby-hamster kidney cells (BHK-21/C13)

Biochemical journal, 1988-07, Vol.253 (1), p.223-227

1988

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Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells

American Journal of Physiology: Cell Physiology, 2000-11, Vol.279 (5), p.C1550-C1557

2000

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Bone and fat: old questions, new insights

Endocrine, 2004-03, Vol.23 (2-3), p.183-188

2004

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Purification of methylglyoxal bis(guanylhydrazone)-induced spermidine N-acetyltransferase from baby hamster kidney cells (BHK-21/C13)

Biochemical pharmacology, 1991-03, Vol.41 (6), p.1090-1092

1991

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Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?

Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro

Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7

Human Trabecular Bone Cells Are Able to Express Both Osteoblastic and Adipocytic Phenotype: Implications for Osteopenic Disorders

Injurious Mechanical Compression of Bovine Articular Cartilage Induces Chondrocyte Apoptosis

Selective inhibitors of apoptotic caspases: implications for novel therapeutic strategies

Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation

Differential expression of Egr-1 in osteoarthritic compared to normal adult human articular cartilage

Human osteoclastoma‐derived stromal cells: Correlation of the ability to form mineralized nodules in vitro with formation of bone in vivo

The selective oestrogen receptor modulators idoxifene and raloxifene have fundamentally different cell-specific oestrogen-response element (ERE)-dependent/independent mechanisms in vitro

Antagonism of oestrogen action in human breast and endometrial cells in vitro: potential novel antitumour agents

Inhibition of caspase-3-like activity prevents apoptosis while retaining functionality of human chondrocytes in vitro

Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications

Playing with bone and fat

Identification and Cloning of a Connective Tissue Growth Factor-like cDNA from Human Osteoblasts Encoding a Novel Regulator of Osteoblast Functions

Idoxifene: a novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats

Expression of a human gene for polyamine transport in Chinese-hamster ovary cells

Therapeutic potential of oestrogen receptor ligands in development for osteoporosis

Drug Discovery and Target Validation

Intermittent treatment with parathyroid hormone (PTH) as well as a non-peptide small molecule agonist of the PTH1 receptor inhibits adipocyte differentiation in human bone marrow stromal cells

Role of caspases in human renal proximal tubular epithelial cell apoptosis

Acetylation of spermidine and methylglyoxal bis(guanylhydrazone) in baby-hamster kidney cells (BHK-21/C13)

Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells

Bone and fat: old questions, new insights

Purification of methylglyoxal bis(guanylhydrazone)-induced spermidine N-acetyltransferase from baby hamster kidney cells (BHK-21/C13)

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