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Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis

Molecules (Basel, Switzerland), 2022-08, Vol.27 (17), p.5487

2022

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Optical control of sphingosine-1-phosphate formation and function

Nature chemical biology, 2019-06, Vol.15 (6), p.623-631

2019

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Gold Nanorods Carrying Paclitaxel for Photothermal-Chemotherapy of Cancer

Bioconjugate chemistry, 2013-03, Vol.24 (3), p.376-386

2013

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Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells

Journal of medicinal chemistry, 2017-02, Vol.60 (4), p.1309-1324

2017

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Regulation of tumor cell – Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis

Advances in biological regulation, 2019-01, Vol.71, p.183-193

2019

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Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential

Journal of lipid research, 2019-03, Vol.60 (3), p.464-474

2019

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Autotaxin and LPA1 and LPA5 receptors exert disparate functions in tumor cells versus the host tissue microenvironment in melanoma invasion and metastasis

Molecular cancer research, 2015-01, Vol.13 (1), p.174-185

2015

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Regulation of Tumor Immunity by Lysophosphatidic Acid

Cancers, 2020-05, Vol.12 (5), p.1202

2020

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Prometastatic Effect of ATX Derived from Alveolar Type II Pneumocytes and B16-F10 Melanoma Cells

Cancers, 2022-03, Vol.14 (6), p.1586

2022

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Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface

Molecular pharmacology, 2013-09, Vol.84 (3), p.415-424

2013

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Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer

Pharmacology & therapeutics (Oxford), 2023-05, Vol.245, p.108414-108414, Article 108414

2023

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E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas

The FASEB journal, 2023-07, Vol.37 (7), p.e23058-n/a

2023

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Optical Control of Lysophosphatidic Acid Signaling

Journal of the American Chemical Society, 2020-06, Vol.142 (24), p.10612-10616

2020

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Osteoclast‐Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss

Arthritis & rheumatology (Hoboken, N.J.), 2019-11, Vol.71 (11), p.1801-1811

2019

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Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment

Cellular signalling, 2021-02, Vol.78, p.109850-109850, Article 109850

2021

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The autotaxin–LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair

Cellular signalling, 2015-09, Vol.27 (9), p.1751-1762

2015

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Functional modulation of lysophosphatidic acid type 2 G‐protein coupled receptor facilitates alveolar bone formation

Journal of cellular physiology, 2024-01, Vol.239 (1), p.112-123

2024

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A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy

Acta pharmacologica Sinica, 2024-02, Vol.45 (2), p.339-353

2024

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Autotaxin inhibition: Development and application of computational tools to identify site-selective lead compounds

Bioorganic & medicinal chemistry, 2013-09, Vol.21 (17), p.5548-5560

2013

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Design and Synthesis of Sulfamoyl Benzoic Acid Analogues with Subnanomolar Agonist Activity Specific to the LPA2 Receptor

Journal of medicinal chemistry, 2014-08, Vol.57 (16), p.7136-7140

2014

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Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition

Bioorganic & medicinal chemistry, 2016-10, Vol.24 (19), p.4660-4674

2016

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Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif

The FEBS journal, 2014-02, Vol.281 (4), p.1017-1028

2014

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Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone

Blood, 2014-11, Vol.124 (20), p.3141-3150

2014

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Combined Mitigation of the Gastrointestinal and Hematopoietic Acute Radiation Syndromes by an LPA2 Receptor-Specific Nonlipid Agonist

Chemistry & biology, 2015-02, Vol.22 (2), p.206-216

2015

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Dermacentor variabilis: Regulation of fibroblast migration by tick salivary gland extract and saliva

Experimental parasitology, 2008-07, Vol.119 (3), p.391-397

2008

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Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis

Optical control of sphingosine-1-phosphate formation and function

Gold Nanorods Carrying Paclitaxel for Photothermal-Chemotherapy of Cancer

Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells

Regulation of tumor cell – Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis

Lysophosphatidic acid type 2 receptor agonists in targeted drug development offer broad therapeutic potential

Autotaxin and LPA1 and LPA5 receptors exert disparate functions in tumor cells versus the host tissue microenvironment in melanoma invasion and metastasis

Regulation of Tumor Immunity by Lysophosphatidic Acid

Prometastatic Effect of ATX Derived from Alveolar Type II Pneumocytes and B16-F10 Melanoma Cells

Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface

Emerging roles of lysophosphatidic acid receptor subtype 5 (LPAR5) in inflammatory diseases and cancer

E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas

Optical Control of Lysophosphatidic Acid Signaling

Osteoclast‐Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss

Dysregulation of lysophospholipid signaling by p53 in malignant cells and the tumor microenvironment

The autotaxin–LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair

Functional modulation of lysophosphatidic acid type 2 G‐protein coupled receptor facilitates alveolar bone formation

A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy

Autotaxin inhibition: Development and application of computational tools to identify site-selective lead compounds

Design and Synthesis of Sulfamoyl Benzoic Acid Analogues with Subnanomolar Agonist Activity Specific to the LPA2 Receptor

Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition

Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif

Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone

Combined Mitigation of the Gastrointestinal and Hematopoietic Acute Radiation Syndromes by an LPA2 Receptor-Specific Nonlipid Agonist

Dermacentor variabilis: Regulation of fibroblast migration by tick salivary gland extract and saliva

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