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5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

Annals of oncology, 2004-07, Vol.15 (7), p.1025-1032

2004

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Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase

Annals of oncology, 2006-01, Vol.17 (1), p.35-42

2006

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Clinical Phase I and Pharmacology Study of Gemcitabine (2', 2'-Difluorodeoxycytidine) Administered in a Two-Weekly Schedule

Journal of chemotherapy (Florence), 2007-04, Vol.19 (2), p.212-221

2007

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mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method

Leukemia, 2000-12, Vol.14 (12), p.2166-2175

2000

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The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells

The international journal of biochemistry & cell biology, 2006, Vol.38 (10), p.1759-1765

2006

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Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells

Biochemical and biophysical research communications, 2003-02, Vol.301 (3), p.675-679

2003

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Selective Protection by Uridine of Growth Inhibition by 5-Fluorouracil (5FU) Mediated by 5FU Incorporation into RNA, But Not the Thymidylate Synthase Mediated Growth Inhibition by 5FU-Leucovorin

Nucleosides, nucleotides & nucleic acids, 2008-06, Vol.27 (6-7), p.733-739

2008

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Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors

Cancer chemotherapy and pharmacology, 2003-07, Vol.52 (1), p.1-12

2003

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Dose-Finding and Pharmacokinetic Study of Cisplatin, Gemcitabine, and SU5416 in Patients With Solid Tumors

Journal of clinical oncology, 2002-03, Vol.20 (6), p.1657-1667

Kuenen, B. C.

2002

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Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs

European journal of cancer (1990), 2000-10, Vol.36 (15), p.1974-1983

2000

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A Comparison Between Stem Cells from the Adult Human Brain and from Brain Tumors

Neurosurgery, 2008-12, Vol.63 (6), p.1022-1034

2008

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Differential mRNA expression of Ara-C–metabolizing enzymes explains Ara-C sensitivity in MLL gene–rearranged infant acute lymphoblastic leukemia

Blood, 2003-02, Vol.101 (4), p.1270-1276

2003

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Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2

Cancer research (Chicago, Ill.), 1999-06, Vol.59 (11), p.2532-2535

1999

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Antiproliferative Activity and Mechanism of Action of Fatty Acid Derivatives of Gemcitabine in Leukemia and Solid Tumor Cell Lines and in Human Xenografts

Nucleosides, nucleotides & nucleic acids, 2004-10, Vol.23 (8-9), p.1329-1333

2004

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Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay

International journal of oncology, 2001-07, Vol.19 (1), p.157

2001

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The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients

Blood, 2004-04, Vol.103 (8), p.2908-2913

2004

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A possible role for methotrexate in the treatment of childhood acute myeloid leukaemia, in particular for acute monocytic leukaemia

European journal of cancer (1990), 2001-03, Vol.37 (4), p.492-498

2001

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Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells

European journal of cancer (1990), 1997, Vol.33 (3), p.471-478

1997

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Phase I Clinical and Pharmacokinetic Study of Oral S-1 in Patients With Advanced Solid Tumors

Journal of clinical oncology, 2000-07, Vol.18 (14), p.2772-2779

2000

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Issues of Normal Tissue Toxicity in Patient and Animal Studies - Effect of Carbogen Breathing in Rats after 5-Fluorouracil Treatment

Acta oncologica, 2001, Vol.40 (5), p.609-614

2001

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Comparison of mRNA Expression Levels Determined with TAQ-Man and Competitive Template RT-PCR

Nucleosides, nucleotides & nucleic acids, 2004-12, Vol.23 (8-9), p.1471-1474

2004

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A Non-Radioactive Sensitive Assay to Measure 5-Fluorouracil Incorporation into DNA of Solid Tumors

Nucleosides, nucleotides & nucleic acids, 2004-10, Vol.23 (8-9), p.1481-1484

2004

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Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance

Leukemia, 2002-05, Vol.16 (5), p.949-951

2002

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A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance

The Journal of biological chemistry, 1998-11, Vol.273 (46), p.30189-30198

1998

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Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma

Cancer chemotherapy and pharmacology, 1993-01, Vol.31 (4), p.269-276

1993

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5-Fluorouracil incorporation into RNA and DNA in relation to thymidylate synthase inhibition of human colorectal cancers

Phase II study of tailored chemotherapy for advanced colorectal cancer with either 5-fluouracil and leucovorin or oxaliplatin and irinotecan based on the expression of thymidylate synthase and dihydropyrimidine dehydrogenase

Clinical Phase I and Pharmacology Study of Gemcitabine (2', 2'-Difluorodeoxycytidine) Administered in a Two-Weekly Schedule

mRNA expression levels of methotrexate resistance-related proteins in childhood leukemia as determined by a standardized competitive template-based RT-PCR method

The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells

Rapid disappearance of deoxyribose-1-phosphate in platelet derived endothelial cell growth factor/thymidine phosphorylase overexpressing cells

Selective Protection by Uridine of Growth Inhibition by 5-Fluorouracil (5FU) Mediated by 5FU Incorporation into RNA, But Not the Thymidylate Synthase Mediated Growth Inhibition by 5FU-Leucovorin

Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors

Dose-Finding and Pharmacokinetic Study of Cisplatin, Gemcitabine, and SU5416 in Patients With Solid Tumors

Cross-resistance in the 2′,2′-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000 to standard and investigational drugs

A Comparison Between Stem Cells from the Adult Human Brain and from Brain Tumors

Differential mRNA expression of Ara-C–metabolizing enzymes explains Ara-C sensitivity in MLL gene–rearranged infant acute lymphoblastic leukemia

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2

Antiproliferative Activity and Mechanism of Action of Fatty Acid Derivatives of Gemcitabine in Leukemia and Solid Tumor Cell Lines and in Human Xenografts

Interference of gemcitabine triphosphate with the measurements of deoxynucleotides using an optimized DNA polymerase elongation assay

The value of fludarabine in addition to ARA-C and G-CSF in the treatment of patients with high-risk myelodysplastic syndromes and AML in elderly patients

A possible role for methotrexate in the treatment of childhood acute myeloid leukaemia, in particular for acute monocytic leukaemia

Biochemical mechanisms of interferon modulation of 5-fluorouracil activity in colon cancer cells

Phase I Clinical and Pharmacokinetic Study of Oral S-1 in Patients With Advanced Solid Tumors

Issues of Normal Tissue Toxicity in Patient and Animal Studies - Effect of Carbogen Breathing in Rats after 5-Fluorouracil Treatment

Comparison of mRNA Expression Levels Determined with TAQ-Man and Competitive Template RT-PCR

A Non-Radioactive Sensitive Assay to Measure 5-Fluorouracil Incorporation into DNA of Solid Tumors

Infants with acute lymphoblastic leukemia: no evidence for high methotrexate resistance

A Structurally Altered Human Reduced Folate Carrier with Increased Folic Acid Transport Mediates a Novel Mechanism of Antifolate Resistance

Prolonged retention of high concentrations of 5-fluorouracil in human and murine tumors as compared with plasma

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