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Translational Medicine in CNS Drug Development

1, 2019

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Diverse Psychotomimetics Act through a Common Signaling Pathway

Science (American Association for the Advancement of Science), 2003-11, Vol.302 (5649), p.1412-1415

2003

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Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor

The Journal of pharmacology and experimental therapeutics, 2002-06, Vol.301 (3), p.1020

2002

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The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions

British journal of pharmacology, 2003-02, Vol.138 (4), p.544-553

2003

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Involvement of Striatal and Extrastriatal DARPP-32 in Biochemical and Behavioral Effects of Fluoxetine (Prozac)

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (5), p.3182-3187

2002

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The safety and tolerability of vortioxetine: Analysis of data from randomized placebo-controlled trials and open-label extension studies

Journal of psychopharmacology (Oxford), 2016-03, Vol.30 (3), p.242-252

2016

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Adolescent Female Cannabinoid Exposure Diminishes the Reward-Facilitating Effects of Δ9-Tetrahydrocannabinol and d-Amphetamine in the Adult Male Offspring

Frontiers in pharmacology, 2017-04, Vol.8, p.225-225

2017

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A meta-analysis of the efficacy of vortioxetine in patients with major depressive disorder (MDD) and high levels of anxiety symptoms

Journal of affective disorders, 2016-12, Vol.206, p.140-150

2016

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Melanin-Concentrating Hormone-1 Receptor Modulates Neuroendocrine, Behavioral, and Corticolimbic Neurochemical Stress Responses in Mice

Neuropsychopharmacology (New York, N.Y.), 2006-06, Vol.31 (6), p.1135-1145

2006

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Mesolimbic Dopamine Super-Sensitivity in Melanin-Concentrating Hormone-1 Receptor-Deficient Mice

The Journal of neuroscience, 2005-01, Vol.25 (4), p.914-922

2005

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Cannabinoid CB1 receptor antagonism modulates plasma corticosterone in rodents

European journal of pharmacology, 2006-12, Vol.551 (1-3), p.162-167

2006

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SAGE-217, A Novel GABA A Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies

Clinical pharmacokinetics, 2020-01, Vol.59 (1), p.111

2020

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CB1 Receptor Antagonism Increases Hippocampal Acetylcholine Release: Site and Mechanism of Action

Molecular pharmacology, 2006-10, Vol.70 (4), p.1236-1245

2006

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DARPP-32 Mediates Serotonergic Neurotransmission in the Forebrain

Proceedings of the National Academy of Sciences - PNAS, 2002-03, Vol.99 (5), p.3188-3193

2002

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SAGE-217, A Novel GABAA Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies

Clinical pharmacokinetics, 2020, Vol.59 (1), p.111-120

2020

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Attenuation of Cocaine-Induced Conditioned Place Preference and Motor Activity via Cannabinoid CB2 Receptor Agonism and CB1 Receptor Antagonism in Rats

The international journal of neuropsychopharmacology, 2017-03, Vol.20 (3), p.269-278

2017

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Alterations in 5-HT1B receptor function by p11 in depression-like states

Science (American Association for the Advancement of Science), 2006-01, Vol.311 (5757), p.77-80

2006

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Efficacy, safety, and tolerability of vortioxetine for the treatment of major depressive disorder in patients aged 55 years or older

CNS spectrums, 2017-08, Vol.22 (4), p.348-362

2017

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Lack of Effect of Vortioxetine on the Pharmacokinetics and Pharmacodynamics of Ethanol, Diazepam, and Lithium

Clinical pharmacokinetics, 2016-09, Vol.55 (9), p.1115-1127

2016

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Clinical implications of directly switching antidepressants in well-treated depressed patients with treatment-emergent sexual dysfunction: a comparison between vortioxetine and escitalopram

CNS spectrums, 2020-02, Vol.25 (1), p.50-63

2020

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Modulation of neurotransmitter release in orexin/hypocretin-2 receptor knockout mice: A microdialysis study

Journal of neuroscience research, 2012-03, Vol.90 (3), p.588-596

2012

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Effects of vortioxetine on functional capacity across different levels of functional impairment in patients with major depressive disorder: a University of California, San Diego Performance-based Skills Assessment (UPSA) analysis

Current medical research and opinion, 2020-01, Vol.36 (1), p.117-124

2020

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Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes

The international journal of neuropsychopharmacology, 2003-03, Vol.6 (1), p.1-11, Article S1461145702003188

2003

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Functional alterations of nicotinic neurotransmission in dopamine transporter knock-out mice

Neuropharmacology, 2007-06, Vol.52 (7), p.1496-1508

2007

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Translational Medicine in CNS Drug Development

Diverse Psychotomimetics Act through a Common Signaling Pathway

Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor

The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions

Involvement of Striatal and Extrastriatal DARPP-32 in Biochemical and Behavioral Effects of Fluoxetine (Prozac)

The safety and tolerability of vortioxetine: Analysis of data from randomized placebo-controlled trials and open-label extension studies

Adolescent Female Cannabinoid Exposure Diminishes the Reward-Facilitating Effects of Δ9-Tetrahydrocannabinol and d-Amphetamine in the Adult Male Offspring

A meta-analysis of the efficacy of vortioxetine in patients with major depressive disorder (MDD) and high levels of anxiety symptoms

Melanin-Concentrating Hormone-1 Receptor Modulates Neuroendocrine, Behavioral, and Corticolimbic Neurochemical Stress Responses in Mice

Mesolimbic Dopamine Super-Sensitivity in Melanin-Concentrating Hormone-1 Receptor-Deficient Mice

Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas

Cannabinoid CB1 receptor antagonism modulates plasma corticosterone in rodents

SAGE-217, A Novel GABA A Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies

CB1 Receptor Antagonism Increases Hippocampal Acetylcholine Release: Site and Mechanism of Action

DARPP-32 Mediates Serotonergic Neurotransmission in the Forebrain

SAGE-217, A Novel GABAA Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies

Attenuation of Cocaine-Induced Conditioned Place Preference and Motor Activity via Cannabinoid CB2 Receptor Agonism and CB1 Receptor Antagonism in Rats

Alterations in 5-HT1B receptor function by p11 in depression-like states

Efficacy, safety, and tolerability of vortioxetine for the treatment of major depressive disorder in patients aged 55 years or older

Lack of Effect of Vortioxetine on the Pharmacokinetics and Pharmacodynamics of Ethanol, Diazepam, and Lithium

Clinical implications of directly switching antidepressants in well-treated depressed patients with treatment-emergent sexual dysfunction: a comparison between vortioxetine and escitalopram

Modulation of neurotransmitter release in orexin/hypocretin-2 receptor knockout mice: A microdialysis study

Effects of vortioxetine on functional capacity across different levels of functional impairment in patients with major depressive disorder: a University of California, San Diego Performance-based Skills Assessment (UPSA) analysis

Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes

Functional alterations of nicotinic neurotransmission in dopamine transporter knock-out mice

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