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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Nature reviews. Drug discovery, 2019-05, Vol.18 (5), p.379-401

2019

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An open-source platform for analyzing and sharing worm-behavior data

Nature methods, 2018-09, Vol.15 (9), p.645-646

2018

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Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

Frontiers in immunology, 2019-10, Vol.10, p.2565-2565

2019

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Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes

Cellular and Molecular Life Sciences, 2015-11, Vol.72 (21), p.4027-4047

2015

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Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

Cell reports (Cambridge), 2019-04, Vol.27 (2), p.467-480.e6

2019

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Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

Proceedings of the National Academy of Sciences - PNAS, 2012-09, Vol.109 (37), p.14912-14917

2012

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A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Nature protocols, 2016-10, Vol.11 (10), p.1798-1816

2016

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Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

Nature protocols, 2020-06, Vol.15 (6), p.2071-2106

2020

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Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

ACS chemical biology, 2018-08, Vol.13 (8), p.2308-2319

2018

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Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis

Nature chemical biology, 2015-10, Vol.11 (10), p.784-792

2015

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C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

PLoS genetics, 2008-03, Vol.4 (3), p.e1000027

2008

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Cellular Regulation of Amyloid Formation in Aging and Disease

Frontiers in neuroscience, 2017-02, Vol.11, p.64-64

2017

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A sudden collapse: the disaggregation of amyloid fibres

The EMBO journal, 2022-08, Vol.41 (16), p.e111700-n/a

2022

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Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease

Cell reports (Cambridge), 2016-09, Vol.16 (11), p.3041-3051

2016

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Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases

PloS one, 2010-01, Vol.5 (1), p.e8870-e8870

2010

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An induced mutation in tomato eIF4E leads to immunity to two potyviruses

PloS one, 2010-06, Vol.5 (6), p.e11313-e11313

2010

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SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease

PloS one, 2011-11, Vol.6 (11), p.e27746

2011

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A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo

Chemphyschem, 2011-02, Vol.12 (3), p.673-680

2011

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Regulation of Age-Related Protein Toxicity

Frontiers in cell and developmental biology, 2021-03, Vol.9, p.637084

2021

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Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

PloS one, 2009-11, Vol.4 (11), p.e7930-e7930

2009

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Polyglutamine protein aggregates are dynamic

Nature cell biology, 2002-10, Vol.4 (10), p.826-831

2002

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Genome-Wide RNA Interference Screen Identifies Previously Undescribed Regulators of Polyglutamine Aggregation

Proceedings of the National Academy of Sciences - PNAS, 2004-04, Vol.101 (17), p.6403-6408

2004

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Tryptophan metabolism: entering the field of aging and age-related pathologies

Trends in molecular medicine, 2013-06, Vol.19 (6), p.336-344

2013

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Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease

Journal of neurochemistry, 2019-12, Vol.151 (5), p.656-668

2019

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A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (6), p.E1009-E1017

2017

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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

An open-source platform for analyzing and sharing worm-behavior data

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target

Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes

Transcriptomics-Based Screening Identifies Pharmacological Inhibition of Hsp90 as a Means to Defer Aging

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Assessing motor-related phenotypes of Caenorhabditis elegans with the wide field-of-view nematode tracking platform

Multistep Inhibition of α‑Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

Extracellular 4'-phosphopantetheine is a source for intracellular coenzyme A synthesis

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

Cellular Regulation of Amyloid Formation in Aging and Disease

A sudden collapse: the disaggregation of amyloid fibres

Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease

Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases

An induced mutation in tomato eIF4E leads to immunity to two potyviruses

SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease

A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo

Regulation of Age-Related Protein Toxicity

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

Polyglutamine protein aggregates are dynamic

Genome-Wide RNA Interference Screen Identifies Previously Undescribed Regulators of Polyglutamine Aggregation

Tryptophan metabolism: entering the field of aging and age-related pathologies

Age‐ and disease‐specific changes of the kynurenine pathway in Parkinson’s and Alzheimer’s disease

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

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