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Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14426-14447

2021

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DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.783-792

2004

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Investigation of a conserved stacking interaction in target site recognition by the U1A protein

Nucleic acids research, 2002-01, Vol.30 (2), p.550

2002

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Recognition of an Essential Adenine at a Protein−RNA Interface: Comparison of the Contributions of Hydrogen Bonds and a Stacking Interaction

Journal of the American Chemical Society, 1999-09, Vol.121 (38), p.8951-8952

1999

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Contribution of RNA Conformation to the Stability of a High-Affinity RNA−Protein Complex

Journal of the American Chemical Society, 2000-07, Vol.122 (29), p.7130-7131

2000

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C8-Guanine Adduct-Induced Stabilization of a −1 Frame Shift Intermediate in a Nonrepetitive DNA Sequence

Biochemistry (Easton), 1999-10, Vol.38 (42), p.14056-14062

1999

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Investigation of a conserved stacking interaction in target site recognition by the U1A protein

Nucleic acids research, 2002-01, Vol.30 (2), p.550-558

Shiels, J. C.

2002

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Solution properties and computational analysis of an oligodeoxynucleotide containing N-(deoxyguanosin-8-yl)-1-aminopyrene

Carcinogenesis (New York), 1996-01, Vol.17 (1), p.133-144

1996

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Synthesis and characterization of oligodeoxynucleotides containing N-(deoxyguanosin-8-yl)-1-aminopyrene

Tetrahedron letters, 1993-04, Vol.34 (14), p.2247-2250

1993

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Spectroscopic and thermodynamic studies of the major DNA adduct formed by the carcinogen 1-nitropyrene

Nolan, Scott J

1998

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A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest

The New England journal of medicine, 2018-08, Vol.379 (8), p.711-721

2018

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Pushing precipitation to the extremes in distributed experiments: recommendations for simulating wet and dry years

Global change biology, 2017-05, Vol.23 (5), p.1774-1782

2017

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Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial

JAMA : the journal of the American Medical Association, 2018-08, Vol.320 (8), p.779

2018

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Plant traits and soil fertility mediate productivity losses under extreme drought in C₃ grasslands

Ecology (Durham), 2021-10, Vol.102 (10), p.1-9

2021

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Measuring pain in dogs and cats using structured behavioural observation

The veterinary journal (1997), 2018-06, Vol.236, p.72-79

2018

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Responses of a semiarid grassland to recurrent drought are linked to community functional composition

Ecology (Durham), 2023-02, Vol.104 (2), p.e3920-n/a

2023

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Definitive Glasgow acute pain scale for cats: validation and intervention level

Veterinary record, 2017-05, Vol.180 (18), p.449-449

2017

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Stevens‐Johnson syndrome and toxic epidermal necrolysis‐like reactions to checkpoint inhibitors: a systematic review

International journal of dermatology, 2020-06, Vol.59 (6), p.e183-e188

2020

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Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score

Animal welfare, 2007-05, Vol.16 (S1), p.97-104

2007

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Shifts in plant functional composition following long‐term drought in grasslands

The Journal of ecology, 2019-09, Vol.107 (5), p.2133-2148

2019

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Modified (NHC)Pd(allyl)Cl (NHC = N-Heterocyclic Carbene) Complexes for Room-Temperature Suzuki−Miyaura and Buchwald−Hartwig Reactions

Journal of the American Chemical Society, 2006-03, Vol.128 (12), p.4101-4111

2006

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Acute Phase Proteins in Bovine Milk in an Experimental Model of Staphylococcus aureus Subclinical Mastitis

Journal of dairy science, 2006-05, Vol.89 (5), p.1488-1501

2006

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Epidemiology and outcomes from out-of-hospital cardiac arrests in England

Resuscitation, 2017-01, Vol.110, p.133-140

2017

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Quality of life is reduced in obese dogs but improves after successful weight loss

The veterinary journal (1997), 2012-06, Vol.192 (3), p.428-434

2012

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Discovery of the Oxadiazine FRM-024: A Potent CNS-Penetrant Gamma Secretase Modulator

DiPOA ([8-(3,3-diphenyl-propyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-3-yl]-acetic acid), a novel, systemically available, and peripherally restricted mu opioid agonist with antihyperalgesic activity: I. In vitro pharmacological characterization and pharmacokinetic properties

Investigation of a conserved stacking interaction in target site recognition by the U1A protein

Recognition of an Essential Adenine at a Protein−RNA Interface: Comparison of the Contributions of Hydrogen Bonds and a Stacking Interaction

Contribution of RNA Conformation to the Stability of a High-Affinity RNA−Protein Complex

C8-Guanine Adduct-Induced Stabilization of a −1 Frame Shift Intermediate in a Nonrepetitive DNA Sequence

Investigation of a conserved stacking interaction in target site recognition by the U1A protein

Solution properties and computational analysis of an oligodeoxynucleotide containing N-(deoxyguanosin-8-yl)-1-aminopyrene

Synthesis and characterization of oligodeoxynucleotides containing N-(deoxyguanosin-8-yl)-1-aminopyrene

Spectroscopic and thermodynamic studies of the major DNA adduct formed by the carcinogen 1-nitropyrene

A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest

Pushing precipitation to the extremes in distributed experiments: recommendations for simulating wet and dry years

Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial

Plant traits and soil fertility mediate productivity losses under extreme drought in C₃ grasslands

Out-of-hospital cardiac arrest across the World: First report from the International Liaison Committee on Resuscitation (ILCOR)

Measuring pain in dogs and cats using structured behavioural observation

Responses of a semiarid grassland to recurrent drought are linked to community functional composition

Definitive Glasgow acute pain scale for cats: validation and intervention level

Stevens‐Johnson syndrome and toxic epidermal necrolysis‐like reactions to checkpoint inhibitors: a systematic review

Development of the short-form Glasgow Composite Measure Pain Scale (CMPS-SF) and derivation of an analgesic intervention score

Shifts in plant functional composition following long‐term drought in grasslands

Modified (NHC)Pd(allyl)Cl (NHC = N-Heterocyclic Carbene) Complexes for Room-Temperature Suzuki−Miyaura and Buchwald−Hartwig Reactions

Acute Phase Proteins in Bovine Milk in an Experimental Model of Staphylococcus aureus Subclinical Mastitis

Epidemiology and outcomes from out-of-hospital cardiac arrests in England

Quality of life is reduced in obese dogs but improves after successful weight loss

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