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FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3741-3752

2019

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Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

Nature communications, 2020-03, Vol.11 (1), p.1383-1383, Article 1383

2020

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Protein Kinase Inhibitors: Insights into Drug Design from Structure

Science (American Association for the Advancement of Science), 2004-03, Vol.303 (5665), p.1800-1805

2004

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Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

Nature communications, 2024-08, Vol.15 (1), p.6807-14, Article 6807

2024

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Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Nature communications, 2020-10, Vol.11 (1), p.5047-5047, Article 5047

2020

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Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

Scientific reports, 2023-07, Vol.13 (1), p.10718-10718, Article 10718

2023

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structure of CDK4/cyclin D3 has implications for models of CDK activation

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (11), p.4171-4176

2009

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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Nature communications, 2015-04, Vol.6 (1), p.6769-6769, Article 6769

2015

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Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1233-1243

2011

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The Structural Basis for Control of Eukaryotic Protein Kinases

Annual review of biochemistry, 2012-01, Vol.81 (1), p.587-613

2012

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Presenting your structures: the CCP4mg molecular-graphics software

Acta crystallographica. Section D, Biological crystallography., 2011-04, Vol.67 (4), p.386-394

2011

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The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

Nature cell biology, 1999-11, Vol.1 (7), p.438-443

1999

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Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1746-1767

2017

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How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-dependent Kinase 2-Cyclin A

The Journal of biological chemistry, 2007-02, Vol.282 (5), p.3173-3181

2007

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.4071-4088

2021

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MDM2-p53 protein–protein interaction inhibitors: A-ring substituted isoindolinones

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5916-5919

2011

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The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant

Acta crystallographica. Section D, Biological crystallography., 2013-08, Vol.69 (8), p.1358-1366

2013

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Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2797-2804

2000

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Fragment expansion with NUDELs - poised DNA-encoded libraries

Chemical science (Cambridge), 2023-08, Vol.14 (31), p.8288-8294

2023

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Specificity Determinants of Recruitment Peptides Bound to Phospho-CDK2/Cyclin A

Biochemistry (Easton), 2002-12, Vol.41 (52), p.15625-15634

2002

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Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design

The journal of physical chemistry letters, 2016-09, Vol.7 (17), p.3452-3457

2016

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Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Journal of the American Chemical Society, 2006-05, Vol.128 (18), p.6012-6013

2006

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Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase

Biochemical journal, 2005-01, Vol.385 (Pt 2), p.605-612

2005

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The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

ACS chemical biology, 2012-05, Vol.7 (5), p.811-816

2012

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FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors

Protein Kinase Inhibitors: Insights into Drug Design from Structure

Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

structure of CDK4/cyclin D3 has implications for models of CDK activation

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

The Structural Basis for Control of Eukaryotic Protein Kinases

Presenting your structures: the CCP4mg molecular-graphics software

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines

How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-dependent Kinase 2-Cyclin A

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction

MDM2-p53 protein–protein interaction inhibitors: A-ring substituted isoindolinones

The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant

Identification of Novel Purine and Pyrimidine Cyclin-Dependent Kinase Inhibitors with Distinct Molecular Interactions and Tumor Cell Growth Inhibition Profiles

Fragment expansion with NUDELs - poised DNA-encoded libraries

Specificity Determinants of Recruitment Peptides Bound to Phospho-CDK2/Cyclin A

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase

An Alkynylpyrimidine-Based Covalent Inhibitor That Targets a Unique Cysteine in NF-κB-Inducing Kinase

The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508

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