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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Nature Medicine, 2013-09, Vol.19 (9), p.1157-1160

2013

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Lead Optimization of a Novel Series of Imidazo[1,2‑a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent

Journal of medicinal chemistry, 2014-06, Vol.57 (12), p.5293-5305

2014

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Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7297-7301

2012

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Discovery of 3,4-dihydropyrimidin-2(1H)-ones with inhibitory activity against HIV-1 replication

Bioorganic & medicinal chemistry letters, 2012-03, Vol.22 (5), p.2119-2124

2012

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Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors

European journal of medicinal chemistry, 2013-12, Vol.70, p.315-325

2013

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Synthesis and structure-activity studies of side chain analogues of the anti-tubercular agent, Q203

European journal of medicinal chemistry, 2017-01, Vol.125, p.807-815

2017

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Automated HTS/HCS for antivirals using visual HIV full replication assays

Retrovirology, 2009-09, Vol.6 (Suppl 2), p.P82-P82, Article P82

2009

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Pd-catalyzed ortho-arylation of 3,4-dihydroisoquinolones via C–H bond activation: synthesis of 8-aryl-1,2,3,4-tetrahydroisoquinolines

Tetrahedron letters, 2009-03, Vol.50 (11), p.1229-1235

2009

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A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability

Bioorganic & medicinal chemistry letters, 2012-04, Vol.22 (7), p.2522-2526

2012

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Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5- a]pyrimidines as novel PDE-4 inhibitors

Bioorganic & medicinal chemistry letters, 2010-02, Vol.20 (3), p.922-926

2010

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Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumin-induced asthma murine model

European journal of pharmacology, 2012-06, Vol.685 (1-3), p.141-148

2012

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Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action

European journal of medicinal chemistry, 2014-05, Vol.78, p.35-42

2014

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Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.153-157

2013

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Novel Synthesis of Chiral 5-Cyanomethyl-3,4-dihydroxy-2-iodomethyltetrahydrofuran from 3-Diphenylmethyl-5-(1,2-dihydroxy-3-butenyl)isoxazolines via Iodoetheration Reaction

Bulletin of the Korean Chemical Society, 2005, 26(10), , pp.1597-1599

2005

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A Substrate Mimetic Approach for Influenza Neuraminidase Inhibitors

Bulletin of the Korean Chemical Society, 2004, 25(10), , pp.1575-1577

2004

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Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

ACS medicinal chemistry letters, 2012-08, Vol.3 (8), p.678-682

2012

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Identification of two HIV inhibitors that also inhibit human RNaseH2

Molecules and Cells, 2013, 36(3), , pp.212-218

2013

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EK-6136 (3-methyl-4-( O-methyl-oximino)-1-phenylpyrazolin-5-one): A novel Cdc25B inhibitor with antiproliferative activity

European journal of pharmacology, 2005-12, Vol.528 (1), p.37-42

2005

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Synthesis of 3′-C-substituted thymidine derivatives by free-radical techniques: scope and limitations

Carbohydrate research, 2007-02, Vol.342 (2), p.259-267

2007

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Complete 1 H and 13 C assignments of some epipodophyllotoxin derivatives

Magnetic resonance in chemistry, 2003-04, Vol.41 (4), p.283-286

2003

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Antitumor activity ofTrichosanthes kirilowii

Archives of pharmacal research, 1994-10, Vol.17 (5), p.348-353

1994

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Reduction of ketones to corresponding alcohols with magnesium metal in absolute alcohols

Tetrahedron letters, 2006-01, Vol.47 (1), p.9-12

2006

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Complete 1H and 13C assignments of some epipodophyllotoxin derivatives

Magnetic resonance in chemistry, 2003-04, Vol.41 (4), p.283-286

2003

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Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Lead Optimization of a Novel Series of Imidazo[1,2‑a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent

High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor

Discovery of 3,4-dihydropyrimidin-2(1H)-ones with inhibitory activity against HIV-1 replication

Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors

Synthesis and structure-activity studies of side chain analogues of the anti-tubercular agent, Q203

Automated HTS/HCS for antivirals using visual HIV full replication assays

Pd-catalyzed ortho-arylation of 3,4-dihydroisoquinolones via C–H bond activation: synthesis of 8-aryl-1,2,3,4-tetrahydroisoquinolines

A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability

Design, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5- a]pyrimidines as novel PDE-4 inhibitors

Discovery of a novel orally active PDE-4 inhibitor effective in an ovalbumin-induced asthma murine model

Discovery of 2-iminobenzimidazoles as potent hepatitis C virus inhibitors with a novel mechanism of action

Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors

Novel Synthesis of Chiral 5-Cyanomethyl-3,4-dihydroxy-2-iodomethyltetrahydrofuran from 3-Diphenylmethyl-5-(1,2-dihydroxy-3-butenyl)isoxazolines via Iodoetheration Reaction

A Substrate Mimetic Approach for Influenza Neuraminidase Inhibitors

Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Identification of two HIV inhibitors that also inhibit human RNaseH2

EK-6136 (3-methyl-4-( O-methyl-oximino)-1-phenylpyrazolin-5-one): A novel Cdc25B inhibitor with antiproliferative activity

Synthesis of 3′-C-substituted thymidine derivatives by free-radical techniques: scope and limitations

Complete 1 H and 13 C assignments of some epipodophyllotoxin derivatives

High Content Screening Identifies Decaprenyl-Phosphoribose 2' Epimerase as a Target for Intracellular Antimycobacterial Inhibitors: e1000645

Antitumor activity ofTrichosanthes kirilowii

Reduction of ketones to corresponding alcohols with magnesium metal in absolute alcohols

Complete 1H and 13C assignments of some epipodophyllotoxin derivatives

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