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SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

Antimicrobial Agents and Chemotherapy, 2006-03, Vol.50 (3), p.1013-1020

2006

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Preclinical Characterization of the Antiviral Activity of SCH 900518 (Narlaprevir), a Novel Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease

Antimicrobial Agents and Chemotherapy, 2010-06, Vol.54 (6), p.2365-2370

2010

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Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4219-4223

2008

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Aging of Proteins: Immunological Detection of a Glucose-derived Pyrrole Formed during Maillard Reaction in vivo

The Journal of biological chemistry, 1989-03, Vol.264 (7), p.3758-3764

1989

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Structural Interaction of Natural and Synthetic Inhibitors with the Venom Metalloproteinase, Atrolysin C (Form d)

Proceedings of the National Academy of Sciences - PNAS, 1994-08, Vol.91 (18), p.8447-8451

1994

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Impact of Naturally Occurring Variants of HCV Protease on the Binding of Different Classes of Protease Inhibitors

Biochemistry (Easton), 2006-02, Vol.45 (5), p.1353-1361

2006

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Mechanism of formation of the putative advanced glycosylation end product and protein cross-link 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole

The Journal of biological chemistry, 1988-08, Vol.263 (22), p.10646-10652

1988

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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Cancer research (Chicago, Ill.), 1998-11, Vol.58 (21), p.4947-4956

1998

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Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

Journal of medicinal chemistry, 1997-12, Vol.40 (26), p.4290-4301

1997

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Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6229-6235

2005

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Characterization of resistance mutations against HCV ketoamide protease inhibitors

Antiviral research, 2008-03, Vol.77 (3), p.177-185

2008

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Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity

Journal of medicinal chemistry, 1998-05, Vol.41 (10), p.1561-1567

1998

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A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease

Analytical biochemistry, 1999-06, Vol.270 (2), p.268-275

1999

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Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Accounts of chemical research, 2008-01, Vol.41 (1), p.50-59

2008

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Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation

Bioorganic & medicinal chemistry, 1997-01, Vol.5 (1), p.93-99

1997

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Enzymatic Kinetic Resolution of Piperidine Atropisomers: Synthesis of a Key Intermediate of the Farnesyl Protein Transferase Inhibitor, SCH66336

Journal of organic chemistry, 2000-09, Vol.65 (18), p.5451-5459

2000

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Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity

Bioorganic & medicinal chemistry, 1999-05, Vol.7 (5), p.861-867

1999

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Hepatitis C virus NS3-4A serine protease inhibitors : Use of a P2-P1 cyclopropyl alanine combination for improved potency

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (20), p.4515-4519

2005

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Hepatitis C virus NS3-4A serine protease inhibitors : SAR of P'2 moiety with improved potency

Bioorganic & medicinal chemistry letters, 2005-10, Vol.15 (19), p.4180-4184

2005

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Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations

The Journal of biological chemistry, 2006-03, Vol.281 (12), p.8205-8215

2006

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Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase

Bioorganic & medicinal chemistry, 1997-01, Vol.5 (1), p.101-113

1997

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In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease

Journal of antimicrobial chemotherapy, 2007-01, Vol.59 (1), p.51-58

2007

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Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities

Journal of medicinal chemistry, 1999-07, Vol.42 (14), p.2651-2661

1999

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The chemistry of the Maillard reaction under physiological conditions: a review

Progress in clinical and biological research, 1989, Vol.304, p.85

1989

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Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

Carbohydrate research, 1987-09, Vol.167, p.211-220

1987

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SCH 503034, a Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease, Suppresses Polyprotein Maturation and Enhances the Antiviral Activity of Alpha Interferon in Replicon Cells

Preclinical Characterization of the Antiviral Activity of SCH 900518 (Narlaprevir), a Novel Mechanism-Based Inhibitor of Hepatitis C Virus NS3 Protease

Hepatitis C virus NS3-4A serine protease inhibitors: SAR of new P1 derivatives of SCH 503034

Aging of Proteins: Immunological Detection of a Glucose-derived Pyrrole Formed during Maillard Reaction in vivo

Structural Interaction of Natural and Synthetic Inhibitors with the Venom Metalloproteinase, Atrolysin C (Form d)

Impact of Naturally Occurring Variants of HCV Protease on the Binding of Different Classes of Protease Inhibitors

Mechanism of formation of the putative advanced glycosylation end product and protein cross-link 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

Design, Synthesis, and Biological Activity of m-Tyrosine-Based 16- and 17-Membered Macrocyclic Inhibitors of Hepatitis C Virus NS3 Serine Protease

Characterization of resistance mutations against HCV ketoamide protease inhibitors

Potent, Selective, and Orally Bioavailable Tricyclic Pyridyl Acetamide N-Oxide Inhibitors of Farnesyl Protein Transferase with Enhanced in Vivo Antitumor Activity

A Continuous Spectrophotometric Assay for the Hepatitis C Virus Serine Protease

Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection

Antitumor 8-chlorobenzocycloheptapyridines: a new class of selective, nonpeptidic, nonsulfhydryl inhibitors of ras farnesylation

Enzymatic Kinetic Resolution of Piperidine Atropisomers: Synthesis of a Key Intermediate of the Farnesyl Protein Transferase Inhibitor, SCH66336

Atropisomeric trihalobenzocycloheptapyridine analogues provide stereoselective FPT inhibitors with antitumor activity

Hepatitis C virus NS3-4A serine protease inhibitors : Use of a P2-P1 cyclopropyl alanine combination for improved potency

Hepatitis C virus NS3-4A serine protease inhibitors : SAR of P'2 moiety with improved potency

Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor. Reduced RNA replication fitness and partial rescue by second-site mutations

Discovery of novel nonpeptide tricyclic inhibitors of ras farnesyl protein transferase

In vitro antiviral activity of SCH446211 (SCH6), a novel inhibitor of the hepatitis C virus NS3 serine protease

Identification of Pharmacokinetically Stable 3,10-Dibromo-8-chlorobenzocycloheptapyridine Farnesyl Protein Transferase Inhibitors with Potent Enzyme and Cellular Activities

The chemistry of the Maillard reaction under physiological conditions: a review

Detection of d-glucose-derived pyrrole compounds during maillard reaction under physiological conditions

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