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CYP17 inhibitors for prostate cancer treatment--an update

Current medicinal chemistry, 2008-04, Vol.15 (9), p.868-899

2008

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Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR

British journal of cancer, 2010-09, Vol.103 (7), p.1001-1007

2010

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Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth

British journal of cancer, 2007-04, Vol.96 (8), p.1204-1215

2007

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MS-275 synergistically enhances the growth inhibitory effects of RAMBA VN 66-1 in hormone-insensitive PC-3 prostate cancer cells and tumours

British journal of cancer, 2008-04, Vol.98 (7), p.1234-1243

2008

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Cytochrome p450 retinoic acid 4-hydroxylase inhibitors: potential agents for cancer therapy

Mini reviews in medicinal chemistry, 2002-06, Vol.2 (3), p.261-269

Njar, V C O

2002

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Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice

British journal of cancer, 2006-02, Vol.94 (4), p.513-523

2006

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Effects of new 17α-hydroxylase/C17,20-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo

British journal of cancer, 1999-10, Vol.81 (4), p.622-630

1999

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Aromatase inhibitors and their application in breast cancer treatment

Steroids, 2000-04, Vol.65 (4), p.171-179

2000

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Antiulcer activity of the stem bark extract of Entandrophragma angolense

Phytotherapy research, 1994-02, Vol.8 (1), p.46-48

1994

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Comprehensive pharmacology and clinical efficacy of aromatase inhibitors

Drugs (New York, N.Y.), 1999-08, Vol.58 (2), p.233-255

1999

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Novel 17-Azolyl Steroids, Potent Inhibitors of Human Cytochrome 17α-Hydroxylase-C17,20-lyase (P45017 α): Potential Agents for the Treatment of Prostate Cancer

Journal of medicinal chemistry, 1998-03, Vol.41 (6), p.902-912

1998

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Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications

Journal of Steroid Biochemistry and Molecular Biology, 1998-07, Vol.66 (1), p.1-10

1998

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Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.1905-1908

2000

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Mechanistic studies on aromatase and related CC bond cleaving P-450 enzymes

Journal of steroid biochemistry and molecular biology, 1993-03, Vol.44 (4), p.375-387

1993

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Methyl angolensate: The antiulcer agent of the stem bark of Entandrophragma angolense

Planta medica, 1995-02, Vol.61 (1), p.91-92

1995

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Effects of novel 17-azolyl compounds on androgen synthesis in vitro and in vivo

The Journal of steroid biochemistry and molecular biology, 1999-12, Vol.71 (3), p.145-152

1999

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Pharmacokinetic profile of 3β-hydroxy-17-(1 H-1,2,3-triazol-1-yl)androsta-5,16-diene (VN/87-1), a potent androgen synthesis inhibitor, in mice

The Journal of steroid biochemistry and molecular biology, 2001-09, Vol.78 (3), p.241-246

2001

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Antifertility activity of Quassia amara: Quassin inhibits the steroidogenesis in rat Leydig cells in vitro

Planta medica, 1995-04, Vol.61 (2), p.180-182

1995

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2-methoxycanthin-6-one: a new alkaloid from the stem wood of Quassia amara

Planta medica, 1993-06, Vol.59 (3), p.259-261

1993

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Synthesis of 10β-(1′-azirinyl)estr-4-en-3,17-dione as an aromatase inhibitor

Steroids, 1996-03, Vol.61 (3), p.138-143

1996

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Enzymatic transesterification of steroid esters in organic solvents

Tetrahedron letters, 1987, Vol.28 (52), p.6549-6552

1987

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Synthesis of novel 21-trilluoropregnane steroids : Inhibitors of 17α-hydroxylase/17,20-lyase (17α-lyase)

Steroids, 1997, Vol.62 (6), p.468-473

1997

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Synthesis of 6-hydroximino-3-oxo steroids, a new class of aromatase inhibitor

Journal of the Chemical Society, Perkin Transactions 1, 1992 (5), p.585

1992

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Novel 10β-aziridinyl steroids; inhibitors of aromatase

J. Chem. Soc., Perkin Trans. 1, 1993 (10), p.1161-1168

1993

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Ability of plant callus cultures to synthesize and accumulate lower terpenoids

Phytochemistry (Oxford), 1986, Vol.25 (3), p.629-636

1986

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CYP17 inhibitors for prostate cancer treatment--an update

Prolonging hormone sensitivity in prostate cancer xenografts through dual inhibition of AR and mTOR

Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth

MS-275 synergistically enhances the growth inhibitory effects of RAMBA VN 66-1 in hormone-insensitive PC-3 prostate cancer cells and tumours

Cytochrome p450 retinoic acid 4-hydroxylase inhibitors: potential agents for cancer therapy

Inhibitory effects of retinoic acid metabolism blocking agents (RAMBAs) on the growth of human prostate cancer cells and LNCaP prostate tumour xenografts in SCID mice

Effects of new 17α-hydroxylase/C17,20-lyase inhibitors on LNCaP prostate cancer cell growth in vitro and in vivo

Aromatase inhibitors and their application in breast cancer treatment

Antiulcer activity of the stem bark extract of Entandrophragma angolense

Comprehensive pharmacology and clinical efficacy of aromatase inhibitors

Novel 17-Azolyl Steroids, Potent Inhibitors of Human Cytochrome 17α-Hydroxylase-C17,20-lyase (P45017 α): Potential Agents for the Treatment of Prostate Cancer

Aromatase inhibitors in advanced breast cancer: mechanism of action and clinical implications

Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids

Mechanistic studies on aromatase and related CC bond cleaving P-450 enzymes

Methyl angolensate: The antiulcer agent of the stem bark of Entandrophragma angolense

Effects of novel 17-azolyl compounds on androgen synthesis in vitro and in vivo

Pharmacokinetic profile of 3β-hydroxy-17-(1 H-1,2,3-triazol-1-yl)androsta-5,16-diene (VN/87-1), a potent androgen synthesis inhibitor, in mice

Antifertility activity of Quassia amara: Quassin inhibits the steroidogenesis in rat Leydig cells in vitro

2-methoxycanthin-6-one: a new alkaloid from the stem wood of Quassia amara

Synthesis of 10β-(1′-azirinyl)estr-4-en-3,17-dione as an aromatase inhibitor

Enzymatic transesterification of steroid esters in organic solvents

Synthesis of novel 21-trilluoropregnane steroids : Inhibitors of 17α-hydroxylase/17,20-lyase (17α-lyase)

Synthesis of 6-hydroximino-3-oxo steroids, a new class of aromatase inhibitor

Novel 10β-aziridinyl steroids; inhibitors of aromatase

Ability of plant callus cultures to synthesize and accumulate lower terpenoids

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